Antitumor and antiangiogenic effects of flavonoids

Authors

LI Xiangzhou, College of Materials Science and Engineering of Central South University of Forestry and Technology, Changsha, Hunan 410004, China
LUAN Fangfei, College of Materials Science and Engineering of Central South University of Forestry and Technology, Changsha, Hunan 410004, China
ZHANG Sheng, College of Materials Science and Engineering of Central South University of Forestry and Technology, Changsha, Hunan 410004, China
HUANG Dan, College of Materials Science and Engineering of Central South University of Forestry and Technology, Changsha, Hunan 410004, China; State Key Laboratory of Chinese Medicine Powder and Medicine Innovation in Hunan (Incubation), Hunan University of Chinese

Abstract

Flavonoids drugs are effective, natural, and their toxic and side effect are relatively mild. Otherwise, they have many kinds of biological effects such as anti-inflammatory, anti-bacterial, reducing blood fat, anti-aging and so on.The treatment of malignant tumor is difficult to conquer in the medical community. The majority of clinical antitumor drugs have side effects. This paper elaborated the research progress of anti-tumor and anti-angiogenesis of plant flavonoids from the cellular level, molecular level and animal models level, which can provide a reference for further development and utilization of flavonoids in antitumor and anti-angiogenesis.

Publication Date

1-28-2016

First Page

199

Last Page

201,206

DOI

10.13652/j.issn.1003-5788.2016.01.048

Recommended Citation

Xiangzhou, LI; Fangfei, LUAN; Sheng, ZHANG; and Dan, HUANG (2016) "Antitumor and antiangiogenic effects of flavonoids," Food and Machinery: Vol. 32: Iss. 1, Article 48.
DOI: 10.13652/j.issn.1003-5788.2016.01.048
Available at: https://www.ifoodmm.cn/journal/vol32/iss1/48

References

[1] Lu Bai-yi, Wu Xiao-qin, Tie Xiao-wei, et al. Toxicology and safety of anti-oxidant of bamboo leaves. Part 1: a cute and sub-Chronic toxicity studies on anti-oxidant of bamboo leaves[J]. Food and Chemical Toxicology, 2005, 43(5): 783-792.
[2] 欧阳娜娜, 李湘洲, 罗正. 外场强化提取银杏总黄酮及抗氧化性能研究[J]. 安徽农业科学, 2007, 35(35): 11 368-11 369.
[3] 周佳, 阮征, 江波, 等. 蔬菜抗氧化能力及与酚酸和总黄酮相关性研究[J]. 食品与机械, 2012, 28(3): 139-143.
[4] 马博, 张婷婷, 黎远成, 等. 麻疯树籽壳总黄酮的提取及其羟基自由基清除作用[J]. 食品与机械, 2014, 30(5): 196-199, 205.
[5] 曹清明, 邬靖宇, 钟海雁, 等. 油茶叶中黄酮的超声辅助提取及其抗氧化活性研究[J]. 食品与机械, 2015, 31(3): 162-166.
[6] 杨金会, 谢一民, 冯尚彪, 等. 四种天然双异戊烯基黄酮的合成及其抑菌活性研究[J]. 有机化学, 2013, 33(10): 2 155-2 161.
[7] 黎继烈, 张慧, 王卫, 等. 金橘黄酮抑菌作用研究[J]. 食品与机械, 2008, 24(5): 38-41.
[8] 张李钰. 新型CD20核酸适配体的筛选及其淋巴瘤靶向结合特性的评估[D]. 北京: 北京协和医学院, 2014: 10-11,20.
[9] 延玺, 刘会青, 邹永青, 等. 黄酮类化合物生理活性及合成研究进展[J]. 有机化学, 2008, 28(9): 1 534-1 544.
[10] 文开新, 王成章, 严学兵, 等. 黄酮类化合物生物学活性研究进展[J]. 草业科学, 2010, 27(6): 115-122.
[11] 龚金炎, 张英, 吴晓琴. 黄酮类化合物抗病毒活性的研究进展[J]. 中草药, 2008, 39(4): 623-627.
[12] 朱荣鑫, 张赛龙, 金永生. 黄酮类化合物抗肿瘤作用研究进展[J]. 现代药物与临床, 2010, 25(1): 5-10.
[13] 苏锐, 崔丽霞. 黄酮类化合物抑菌抗病毒活性的研究[J]. 农业技术与装备, 2011(4): 30-33, 35.
[14] 陈志卫, 胡永洲, 吴好好, 等. 黄酮类化合物的合成及其血管舒张作用[J]. 药学学报, 2005, 40(11): 1 001-1 007.
[15] 赵坤英, 解恒革. 葛根总黄酮及葛根素对神经系统保护作用的研究进展[J]. 中国医药科学, 2011, 1(1): 65-67, 77.
[16] 李慧, 杨中林. 橙皮苷降血脂作用的实验研究[J]. 中医药学报, 2010, 38(1): 23-24.
[17] 梅志强, 刘晓燕, 段承刚, 等. 槲皮素抑制人膀胱癌细胞BIU-87生长并诱导其凋亡的研究[J]. 现代医药卫生, 2010, 26(10): 1 538-1 539.
[18] 蔡双莲, 吴峥, 吴进, 等. 黄酮类化合物香叶木素类及其衍生物的合成与生物活性研究[J]. 有机化学, 2012, 32(3): 560-566.
[19] 孙颖桢, 陈科力, 刘震. 江南卷柏总黄酮对HT-29细胞增殖及COX-2 mRNA表达的抑制作用[J]. 中成药, 2010, 32(9): 1 590-1 591.
[20] Kim B R, Jeon Y K, Nam M J. A mechanism of apigenin induced apoptosis is potentially related to anti-angiogenesis and anti-migration in human hepatocellular carcinoma cells[J]. Food Chem. Toxicol., 2011, 49(7): 1 626-1 632.
[21] 黄宇玫, 罗文艳. 竹叶黄酮对小鼠H22肿瘤抑制作用的研究[J]. 实用中西医结合临床, 2012, 12(5): 1-3.
[22] 赵蕊, 陈志宝, 蔡亚平, 等. 蓬子菜黄酮体内外抗宫颈癌作用的研究[J]. 黑龙江畜牧兽医, 2013, 2(3): 132-134, 167.
[23] 杨光明, 燕珂, 顾青, 等. 藏药镰形棘豆总黄酮对SMMC-7721肝癌细胞凋亡及Bcl-2,Bax蛋白表达的影响[J]. 中国药学杂志, 2013, 48(24): 2 113-2 116.
[24] 周娜静, 吴方媛, 王彦玲, 等. 抑制SIRT1表达促进三羟基异黄酮诱导HeLa细胞凋亡的实验观察[J]. 山东医药, 2014, 54(21): 37-38, 41.
[25] 韩彬, 程道梅, 余小平, 等. 染料木黄酮抑制血管内皮生长因子诱导的血管内皮细胞活化及蛋白激酶K活性[J]. 成都医学院学报, 2011, 6(3): 192-195.
[26] 农朝赞, 黄华艺. 黄酮类化合物对蛋白激酶的抑制作用[J]. 中国新药与临床杂志, 2004, 23(8): 548-551.
[27] 林辉, 糜漫天, 常徽. 3,6-二羟黄酮降低白血病细胞HL-60抗氧化酶活性并影响MAPKs信号通路[J]. 第三军医大学学报, 2009, 31(10): 895-897.
[28] 田甜甜, 李际盛, 王亚伟, 等. 染料木黄酮在小细胞肺癌H446细胞中通过抑制FoxM1通路发挥抗肿瘤作用[J]. 山东大学学报: 医学版, 2013, 51(6): 44-48.
[29] 靳西凤, 冉志华. EGCG和染料木黄酮在肿瘤细胞信号传导中的作用[J]. 世界华人消化杂志, 2006, 14(15): 1 507-1 511.
[30] Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. Cell, 2011, 144(5): 646-674.
[31] Taraboletti G, Giavazzi R. Modelling approaches for angiogenesis[J]. Eur. J. Cancer, 2004, 16(40): 881-889.
[32] Haubner R, Wester HJ. Radiolabeled tracers for imaging of tumor angiogenesis and evaluation of anti-angiogenic therapies[J]. Curr. Pharm. Des., 2004, 10(13): 1 439-1 455.
[33] Carmeliet P, Jain R K. Molecular mechanisms and clinical applications of angiogenesis[J]. Nature, 2011, 473(7 347): 298-307.
[34] 曾益新, 张晓实, 刘强. 分子靶向治疗:肿瘤治疗的里程碑[J]. 癌症, 2008, 27(8): 785-787.
[35] 张秀莉. 一种新黄酮类化合物((2S)-8-异戊烯基-7,2,4'-三羟基5-甲氧基二氢黄酮)的抗血管生成作用及其机制研究[D]. 兰州: 兰州大学, 2010.
[36] 蒲丽平. 苦参黄酮Kushecarpin D的抗血管生成作用及自由基相关机制研究[D]. 兰州: 兰州大学, 2010: 26-31.
[37] Fang Jing, Zhou Qiong, Liu Ling-zhi, et al. Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression[J]. Carcinogenesis, 2007, 28(4): 858-864.
[38] Xie Si-rou, Wang Yu, Liu Chang-wei, et al. Liquiritigenin inhibits serum-induced HIF-1alpha and VEGF expression via the AKT/m TOR-p70S6K signal ling pathway in hela cells[J]. Phytother. Res., 2012, 26(8):1 133-1 141.
[39] 郑敏. 射干根茎中的异黄酮类化合物的抗血管生成和抗肿瘤活性[J]. 国外医药: 植物药分册, 2004, 19(6): 260.