Abstract
Objective: The effects of hemp seed and algae oils preparation on blood lipid-lowering and antioxidant activity of mixed hyperlipidemia rats were investigated in this study. 50 rats were randomly divided into 5 groups, i.e., the blank control group, model control group, hemp seed oil and algal oil preparation low dose group (170 mg/kg), medium dose group (340 mg/kg) and high dose group (510 mg/kg). Then their weights of , testis fat pad and perirenal fat pad, fat body ratio, and the activities of malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD) were measured after feeding high fat diet and corresponding drugs. The results indicated that the weights of gain, and testis and perirenal fat pads, fat body ratio, TG, TC and MDA of model control group rats increased significantly, however, the activities of GSH, GSH-Px and SOD, and the high-density lipoprotein cholesterol (HDL-C) reduced significantly (P < 0.05, P < 0.01), compared to the blank group. Moreover, in the high dose and low dose group of hemp seed oil and algae oil preparation, rats weight, weights of testis and perirenal fat pads, body fat ratio decreased significantly, and the content of MDA decreased significantly, while the activities of SOD, GSH and GSH PX significantly increased (P < 0.05 or P < 0.05), compared to the model control group. In conclusion, our results confirmed that the hemp seed and algae oils preparation could regulate blood lipid and possessed strong antioxidant activities.
Publication Date
11-28-2016
First Page
142
Last Page
144
DOI
10.13652/j.issn.1003-5788.2016.11.032
Recommended Citation
Chuanming, BAI and Li, LI
(2016)
"Effect of hemp seed and algae oils preparation on blood lipid-lowering and antioxidant activities for mixed hyperlipidemia rats,"
Food and Machinery: Vol. 32:
Iss.
11, Article 32.
DOI: 10.13652/j.issn.1003-5788.2016.11.032
Available at:
https://www.ifoodmm.cn/journal/vol32/iss11/32
References
[1] 任秀君, 马惠芳, 图娅. 电针对高脂血症合并脑缺血大鼠室管膜下区神经干细胞分化的影响[J]. 针刺研究, 2010, 35(5): 347-353.
[2] 余林德, 陈占利. 中西医治疗高脂血症临床研究进展[J]. 亚太传统医药, 2014, 10(22): 35-37.
[3] 李文雄, 孙赫, 刘文婷. 中医药治疗高脂血症研究进展[J]. 河南中医, 2015, 35(2): 439-442.
[4] 贾丽丽, 陈方红, 李艳婷, 等. 中医药治疗高脂血症的临床研究进展[J]. 湖南中医杂志, 2014, 30(11): 180-181.
[5] 文川元, 马展飞, 柳泽坤, 等. 除湿降脂汤联合舒降之治疗高血脂症的疗效观察[J]. 中国中医药科技, 2015, 22(3): 307-308.
[6] 任汉阳, 孙红光. 火麻仁油的降脂及对过氧化脂质作用的实脸研究[J]. 中国中医药科技, 1997, 4(4): 200.
[7] 扈学俸, 李永进, 王军波, 等. 火麻仁油安全性评价及血清抗氧化功能初步研究[J]. 中国食品卫生杂志, 2008, 20(5): 385-388.
[8] 吴垠, 刘伟娜. 两种微藻油对高脂小鼠脂类代谢及脂质过氧化作用的影响[J]. 中国海洋药物, 2010, 29(6): 48-50.
[9] 萧闵， 李全胜. 火麻仁油与藻油混合物对营养肥胖大鼠的降脂减肥作用研究[J]. 湖北中医药大学学报, 2016, 18(4): 12-15.
[10] 熊本海, 庞之洪, 罗清尧. 中国饲料成分及营养价值表(2013年第24版)制订说明[J]. 中国饲料, 2013(21): 34-43.
[11] IKATA J, WAKATSUKI T, OISHI Y, et al. Leukocytecounts and concentrations and soluble asdhesion molecules aspredictors of coronary atheroselerosis[J]. Coron Artery Dis, 2000, 11(6): 445.
[12] 任天舒, 李林鹏, 姜远英. 高胆固醇血症大鼠自由基代谢紊乱及阿托伐他汀的干预作用[J]. 药学实践杂志, 2007, 25(3): 143-144, 149.
[13] 叶振南, 李楠, 盛丹丹, 等. 青钱柳多糖对高脂血症大鼠血脂及抗脂质过氧化作用的影响[J]. 现代食品科技, 2014, 30(4): 1-5.