Abstract
To investigate the effect of wheat gluten hydrolysate(WGH) rich in glutamine prepared through the enzymatic hydrolysis by trysin on small intestinal mucosal by methotrexate induced mucositis model in rats. The results showed that the WGH can significantly increase intestinal mucosa weight, villus height, crypt depth, protein and DNA content, decrease diamine oxidase level in plasma and increase glutathione content of small intestine mucosa. The WGH can efficiently alleviate the intestinal mucosal injury in rats.
Publication Date
12-28-2016
First Page
148
Last Page
151
DOI
10.13652/j.issn.1003-5788.2016.12.032
Recommended Citation
Bin, YAN; Liya, LIU; Yanzhou, WANG; Xianrong, ZHOU; and Sumei, ZHOU
(2016)
"Effect of wheat gluten hydrolysate on the recovery of intestinal mucositis in methotrexate treated rats,"
Food and Machinery: Vol. 32:
Iss.
12, Article 32.
DOI: 10.13652/j.issn.1003-5788.2016.12.032
Available at:
https://www.ifoodmm.cn/journal/vol32/iss12/32
References
［1］ OWARI M, WASA M, OUE T, et al. Glutamine prevents intestinal mucosal injury induced by cyclophosphamide in rats ［J］. Pediatric Surgery International, 2012, 28(3): 299-303.
［2］ COEFFIER M, DECHELOTTE P. The role of glutamine in intensive care unit patients: Mechanisms of action and clinical outcome ［J］. Nutrition Reviews, 2005, 63(2): 65-69.
［3］ 马洪龙, 韩飞, 李爱科, 等. 谷氨酰胺及其结合肽的研究进展［J］. 粮油食品科技, 2014, 22(3): 76-81.
［4］ XIE Yan-li, LIANG Xin-hong, WEI Min, et al. Optimization of glutamine peptide production from soybean meal and analysis of molecular weight distribution of hydrolysates ［J］. International Journal of Molecular Sciences, 2012, 13(6): 7 483-7 495.
［5］ JIA Chang-jun, DAI Chao-liu, ZHANG Xu, et al. Alanyl-glutamine dipeptide inhibits hepatic ischemia-reperfusion injury in rats ［J］. World Journal of Gastroenterology, 2006, 12(9): 1 373-1 378.
［6］ FARRELL C L, REX K L, CHEN Jian-ning, et al. The effects of keratinocyte growth factor in preclinical models of mucositis ［J］. Cell Proliferation, 2002, 35(Suppl 1): 78-85.
［7］ HOWARTH G S, COOL J C, BOURNE A J, et al. Insulin-like growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate ［J］. Growth Factors, 1998, 15(4): 279-292.
［8］ TRAN C D, HOWARTH G S, COYLE P, et al. Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine ［J］. American Journal of Clinical Nutrition, 2003, 77(5): 1 296-1 303.
［9］ SUN Ming-li, PANG Lei, JU Xue-peng, et al. Attenuating effects of omega-3 fatty acids (Omegaven) on irradiation-induced intestinal injury in mice ［J］. Food and Chemical Toxicology, 2014, 64(2): 275-280.
［10］ YAGASAKI M, HASHIMOTO S. Synthesis and application of dipeptides; current status and perspectives ［J］. Applied Microbiology and Biotechnology, 2008, 81(1): 13-22.
［11］ 顾国达, 尹靖华. 全球中长期粮食供需趋势分析［J］. 华中农业大学学报: 社会科学版, 2014(6): 6-16.
［12］ LEE A J, THALAYASINGAM M, LEE B W. Food allergy in Asia: how does it compare? ［J］. Asia Pacific Allergy, 2013, 3(1): 3.
［13］ QIU Chao-ying, SUN Wei-zheng, CUI Chun, et al. Effect of citric acid deamidation onin vitrodigestibility and antioxidant properties of wheat gluten ［J］. Food Chemistry, 2013, 141(3): 2 772-2 778.
［14］ WANG Jin-shui, ZHAO Mou-ming, ZHAO Qiang-zhong, et al. Antioxidant properties of papain hydrolysates of wheat gluten in different oxidation systems ［J］. Food Chemistry, 2007, 101(4): 1 658-1 663.
［15］ CUI Chun, HU Qing-ling, REN Jiao-yan, et al. The effect of lactic acid bacteria fermentation on the antioxidant activity of wheat gluten pancreatin hydrolysates ［J］. International Journal of Food Science & Technology, 2014, 49(4): 1 048-1 054.
［16］ KOIKAWA N, AOKI E, SUZUKI Y, et al. Wheat gluten hydrolysate affects race performance in the triathlon ［J］. Biomedical Reports, 2013, 1(4): 646-650.
［17］ TANABE S, WATANABE M, ARAI S. Production of a high-glutamine oligopeptide fraction from gluten by enzymatic treatment and evaluation of its nutritional effect on the small intestine of rats ［J］. Journal of food biochemistry, 1992, 16(4): 235-248.
［18］ 谢正飞, 王学东, 李彪, 等. 酵母水解物及小麦水解蛋白对小鼠小肠炎症修复作用的研究［J］. 中国饲料, 2015(23): 38-41.
［19］ 方颂平, 严斌, 朱本国, 等. 小麦面筋蛋白酶解物对小鼠溃疡性结肠炎的影响［J］. 食品与机械, 2016, 32(2): 124-127.
［20］ LEBLOND J, LE PESSOT F, HUBERT-BURON A, et al. Chemotherapy-induced mucositis is associated with changes in proteolytic pathways ［J］. Experimental Biology and Medicine, 2008, 233(2): 219-228.
［21］ SUKHOTNIK I, MOGILNER J G, KARRY R, et al. Effect of oral glutamine on enterocyte turnover during methotrexate-induced mucositis in rats ［J］. Digestion, 2009, 79(1): 5-13.
［22］ 刘秋东, 张中文, 刘凤华, 等. 复方白头翁胶囊对腹泻犬小肠绒毛长度和隐窝深度的影响［J］. 北京农学院学报, 2011, 26(3): 38-40.
［23］ 谈定玉. 谷氨酰胺对危重患者肠道保护作用研究进展［J］. 实用医学杂志, 2005, 21(20): 2 345-2 347.
［24］ 李金敏, 贾海燕, 王俊杰, 等. 谷氨酰胺对溃疡性结肠炎小鼠结肠损伤的影响［J］. 中国应用生理学杂志, 2009, 25(2): 268-272.
［25］ TAZUKE Y, WASA M, SHIMIZU Y, et al. Alanyl-glutamine-supplemented parenteral nutrition prevents intestinal ischemia-reperfusion injury in rats ［J］. Journal of and Parenter Enteral Nutrition, 2003, 27(2): 110-115.
［26］ MORIYAMA K, KOUCHI Y, MORINAGA H, et al. Diamine oxidase, a plasma biomarker in rats to GI tract toxicity of oral fluorouracil anti-cancer drugs ［J］. Toxicology, 2006, 217(2/3): 233-239.
［27］ 张妮, 朱保权, 张庆立, 等. 危重症患儿血浆D-乳酸水平和二胺氧化酶活性与胃肠功能障碍关系研究［J］. 临床儿科杂志, 2006, 24(10): 794-796.