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Abstract

Wheat gluten was hydrolyzed by a specific enzymatic process for prepared Gln-rich wheat gluten hydrolysate(WGH), explored the regulatory effect of WGH on ulcerative colitis by dextran sulfate sodium (DSS) induced colitis model in mice. The results showed that the WGH could alleviate the weight loss and clinical symptoms of DSS-induced colitis in mice, improved the antioxidant capacity of colonic tissue and alleviate the secretion of inflammatory cytokines and the infiltration of inflammatory cells in the colonic tissue of mice. The WGH can efficiently reduce the intestinal inflammation with ulcerative colitis in mice.

Publication Date

2-28-2016

First Page

124

Last Page

127

DOI

10.13652/j.issn.1003-5788.2016.02.032

References

[1] 顾国达, 尹靖华. 全球中长期粮食供需趋势分析[J]. 华中农业大学学报: 社会科学版, 2014(6): 6-16.
[2] 马文峰, 马福廷, 赵宝国, 等. 2013年中国小麦市场回顾及2014年展望[J]. 粮食加工, 2014, 39(3): 1-4.
[3] 张鸣镝, 管骁, 姚惠源. 玉米胚芽蛋白酶解物对小鼠免疫功能的影响[J]. 食品科学, 2007, 28(2): 302-305.
[4] Thewissen B G, Pauly A, Celus I, et al. Inhibition of angiotensin I-converting enzyme by wheat gliadin hydrolysates[J]. Food Chemistry, 2011, 127(4): 1 653-1 658.
[5] 王章存, 王颖, 曹芹, 等. 谷朊粉酶解物的制备及其ACE抑制肽的分离鉴定[J]. 中国酿造, 2015, 34(2): 60-63.
[6] Wang Jin-shui, Zhao Mou-ming, Zhao Qiang-zhong, et al. Antioxidant properties of papain hydrolysates of wheat gluten in different oxidation systems[J]. Food Chemistry, 2007, 101(4): 1 658-1 663.
[7] 王章存, 原媛, 王许东, 等. 谷朊粉酶解条件优化及其抗氧化活性[J]. 中国粮油学报, 2014, 29(11): 7-12.
[8] 孔祥珍, 周惠明, 钱海峰. 小麦面筋蛋白短肽的镇痛作用研究[J]. 食品与生物技术学报, 2007, 26(2): 26-29.
[9] 张亚飞, 乐国伟, 施用晖, 等. 小麦蛋白Alcalase水解物免疫活性肽的研究[J]. 食品与机械, 2006, 22(3): 44-46.
[10] Wang Xiu-qi, Feng You, Shu Gang, et al. Effect of dietary supplementation with hydrolyzed wheat gluten on growth performance, cell immunity and serum biochemical indices of weaned piglets[J]. Agricultural Sciences in China, 2011, 10(6): 938-945.
[11] 张海华. 小麦面筋蛋白源谷氨酰胺肽的酶解准备、结构分析与生理活性研究[D]. 江苏: 江南大学, 2011: 3-4.
[12] 马洪龙, 韩飞, 李爱科, 等. 谷氨酰胺及其结合肽的研究进展[J]. 粮油食品科技, 2014, 22(3): 76-81.
[13] 洪瑾芳. 酶解小麦蛋白对热应激小鼠生理功能的影响[D]. 福建: 福建农林大学, 2009: 31-34.
[14] Yin Hong, Pan Xing-chang, Wang Shao-kang, et al. Protective effect of wheat peptides against small intestinal damage induced by non-steroidal anti-inflammatory drugs in rats [J]. Journal of Integrative Agriculture, 2014, 13(9): 2 019-2 027.
[15] 王延州, 刘丽娅, 钟葵, 等. 高谷氨酰胺低聚小麦肽制备用酶的筛选[J]. 现代食品科技, 2014, 30(2): 177-181, 187.
[16] 赵曼, 高峰. 溃疡性结肠炎发病机制研究进展[J]. 现代生物医学进展, 2010, 16(10): 3 160-3 165.
[17] 李金敏, 贾海燕, 王俊杰, 等. 谷氨酰胺对溃疡性结肠炎小鼠结肠损伤的影响[J]. 中国应用生理学杂志, 2009, 25(2): 268-272.
[18] 李力, 李弼民, 蔡敏, 等. 谷氨酰胺对实验性结肠炎BABL/C小鼠肠黏膜的修复作用[J]. 同济大学学报: 医学版, 2015, 36(2): 11-15.
[19] Tsune I, Ikejima K, Hirose M, et al. Dietary glycine prevents chemical induced experimental colitis in the rat[J]. Gastroenterology, 2003, 125(3): 775-785.
[20] 马洪龙, 韩飞, 李爱科, 等. 碱性蛋白酶水解小麦面筋蛋白制取谷氨酰胺肽的研究[J]. 粮油食品科技, 2014, 22(1): 54-57.
[21] Susana S F, Ana C, Marina S H, et al. Dietary extra virgin olive oil polyphenols supplementation modulates DSS-induced chronic colitis in mice[J]. Journal of Nutritional Biochemistry, 2013, 24(7): 1 401-1 413.
[22] Yan Yu-tao, Kolachala V, Dalmasso G, et al.Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis[J]. PLoS One, 2009, 4(6): e6 073.

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