Abstract
In this study, the formulation of Agaricus Blazei Murill polysaccharide effervescent tablets were optimized. The normalized values (Z) of effervescent tablets of disintegration time and friability was selected as the response value. The influence factors for formulation of Agaricus Blazei Murill polysaccharide effervescent tablets were acid and alkali mass ratio, Citric acid mass fraction, PEG6000 mass fraction. Moreover, a three-variable, five-level code experiment was designed to optimize the formulation of Agaricus Blazei Murill polysaccharide effervescent tablets. The quadratic polynomial regression equation was built and could well describe the relationship between the dependent and independent variables. The optimal formulation was as follows: 0.81 of mass ratio between acid and alkali, citric acid mass ratio 16.96%, and PEG6000 mass ratio 4.08%. Under these conditions, the disintegration time and the friability of the effervescent tablets were qualified, and the normalized values were close to the predicted values of the model. The newly developed formulation of Agaricus Blazei Murill polysaccharide effervescent tablets was feasible and effective.
Publication Date
4-28-2016
First Page
226
Last Page
230
DOI
10.13652/j.issn.1003-5788.2016.04.052
Recommended Citation
Xiaotong, ZHAO; Yanqing, ZHANG; Chengbo, LI; and Huan, ZHANG
(2016)
"Optimization on formulation of Agaricus blazei Murill polysaccharide effervescent tablets by response surface methodology,"
Food and Machinery: Vol. 32:
Iss.
4, Article 52.
DOI: 10.13652/j.issn.1003-5788.2016.04.052
Available at:
https://www.ifoodmm.cn/journal/vol32/iss4/52
References
[1] 殷蓓蓓, 周晓燕, 李爽. 姬松茸的研究与进展[J]. 工业微生物, 2007, 37(2): 52-56.
[2] 刘高翔. 姬松茸中镉的存在形态及其对镉吸附特性的研究[D]. 昆明: 昆明理工大学, 2013: 1-2.
[3] 王丽娟, 张彦青, 王勇, 等. 姬松茸多糖增强免疫作用及急性毒性研究[J]. 食品科学, 2014, 35(13): 258-261.
[4] 张荣娇, 吴天祥. 姬松茸多糖及其生物活性研究进展[J]. 贵州农业科学, 2009, 37(6): 108-110.
[5] 单玉玲, 张艳荣. 姬松茸多糖提取及纯化工艺的研究[D]. 长春: 吉林农业大学, 2007: 1-2.
[6] 曹静, 刘高强, 王晓玲, 等. 可食真菌β-葡聚糖的生物功能及检测技术[J]. 食品与机械, 2014, 30(2): 247-268.
[7] 王伟娟, 冯翠萍, 常明昌, 等. 姬松茸多糖对铅中毒雄性大鼠的抗氧化作用[J]. 中国食品学报, 2013, 13(6): 16-19.
[8] 王斌, 连宾. 食药用真菌多糖的研究与应用[J]. 食品与机械, 2005, 21(6): 96-100.
[9] 郑亚凤, 黄志伟, 陈瑞庆, 等. 姬松茸多糖的抗肿瘤活性[J]. 福建农林大学学报: 自然科学版, 2010, 39(4): 409-412.
[10] 樊廷俊, 钱冠兰, 杜玉堂, 等. 姬松茸提取物组分体外抗病毒感染活性的研究[J]. 中国海洋大学学报: 自然科学版, 2008, 38(5): 775-780.
[11] 国家药典委员会. 中华人民共和国药典: 一部[S]. 北京: 化学工业出版社, 2010.
[12] 胡中慧, 胡晓青. 泡腾片的研究进展[J]. 中华临床医药, 2004, 5(9): 109-110.
[13] 王晓丽, 杨永建, 陈勇, 等. 异叶青兰总黄酮片剂制备及处方优化[J]. 时珍国医国药, 2014, 25(8): 1 878-1 880.
[14] 谢向阳, 邢传峰, 李银科, 等. 琥珀酸美托洛尔缓释微丸型片剂的制备与体外释放度考察[J]. 解放军药学学报, 2014, 30(4): 299-302.
[15] 程新德. 复合辅料用于阿司匹林分散片制备的研究[D]. 山东: 山东大学, 2013: 17-18.
[16] 卢小凤. 凯乐泡腾片的制备工艺及质量标准研究[D]. 广东: 广州中医药大学, 2012: 5.
[17] 周小雅, 黄欣碧, 陈华海, 等. 苦丁茶泡腾片制备工艺的研究[J]. 西北药学杂志, 2012, 27(5): 452-454.
[18] 宿迷菊, 毛志方, 施海根, 等. 食用泡腾片的制备及研究概况[J]. 中国茶叶加工, 2008(2): 20-23.
[19] 郭勤涛, 张令弥, 费庆国. 用于确定性计算仿真的响应面法及其试验设计研究[J]. 航空学报, 2005, 27(1): 55-61.
[20] 廖红强, 邱勇, 杨侠, 等. 对应用层次分析法确定权重系数的探讨[J]. 机械工程师, 2012(6): 22-25.
[21] 王淑华, 林永强. 泡腾片的常用辅料及制备方法[J]. 食品与药品, 2006, 8(3): 70-72.
[22] 乐龙, 覃艳, 王志祥. 响应曲面法优化超声提取辣椒中辣椒红色素的工艺研究[J]. 中国药科大学学报, 2011, 42(6): 573-577.
[23] 张泽志, 韩春亮, 李成未. 响应面法在试验设计与优化中的应用[J]. 河南教育学院学报: 自然科学版, 2011, 20(4): 34-37.