In vivo toxicity assessment of aflatoxin B1-contaminated corn after ozone degradation

Authors

LUO Xiaohu, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan Univers
QI Lijun, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan Univers
WANG Ren, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan Univers
WANG Li, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan Univers
LI Yongfu, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan Univers
YANG Dan, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan Univers
YU Xiaobin, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, China
CHEN Zhengxing, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan Univers

Abstract

Aflatoxin B1-contaminated corn (ACC) (83.0 μg/kg) was treated for 40 min at 90 mg/L ozone. And mice were used to assess the vivo toxicity of ozone treated ACC. Results indicated that compared with basal feedstuff, the mean weight of mice fed with ACC significantly decreased (P＜0.05). Whereas, the liver and kidney/body weight ratio increased significantly (P＜0.05). Alanine transaminase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in serum increased significantly (P＜0.05). The total protein (TP), albumin (ALB), and globulin (GLB) content significantly decreased (P＜0.05). When mice were fed with the ozone-treated ACC, no significant differences were observed in the mice mean weight, as well as the liver and kidney/body weight ratio. Additionally, no significant differences occurred in the major serum indexes ALT, TP, ALB, and GLB (P＞0.05). Meanwhile, AST and ALP increased significantly (P＜0.05). The study indicated that ACC can lead to significant changes in various physiological characteristics and biochemical indexes in liver and kidney tissues, while the ozone-treated ACC could significantly improve these changes.

Publication Date

8-28-2016

First Page

58

Last Page

62

DOI

10.13652/j.issn.1003-5788.2016.08.014

Recommended Citation

Xiaohu, LUO; Lijun, QI; Ren, WANG; Li, WANG; Yongfu, LI; Dan, YANG; Xiaobin, YU; and Zhengxing, CHEN (2016) "In vivo toxicity assessment of aflatoxin B1-contaminated corn after ozone degradation," Food and Machinery: Vol. 32: Iss. 8, Article 14.
DOI: 10.13652/j.issn.1003-5788.2016.08.014
Available at: https://www.ifoodmm.cn/journal/vol32/iss8/14

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