•  
  •  
 

Abstract

The chemical components of Oenanthe javanica from Guizhou and the hypoglycemic effect of its extracts on the diabetic mice induced by streptozotocin (STZ) was investigated in this paper. The chemical composition type in the wild O. javanica was detected in a single prediction experiment by using various chemical components of natural medicine. The total phenolic acids, flavonoids and sugar of O. javanica were determined by spectrophotometry. Diabetic mice model was established by STZ, and metformin was used as a positive control, the extracts from O. javanica was fed, blood glucose was measured. The results showed that O. javanica contained phenols, flavonoids, alkaloids and other active ingredients, and the total phenolic acids, flavonoids and sugar of O. javanica were found higher than other kinds of compounds. The extract from O. javanica showed a certain hypoglycemic activity, and according to the data, decreasing blood glucose from 27.6 to 17.7. Thus O. javanica from Guizhou contains a variety of natural drug chemical composition, showing a certain hypoglycemic effect, and it was valuable to research and explore it.

Publication Date

1-28-2017

First Page

153

Last Page

155,171

DOI

10.13652/j.issn.1003-5788.2017.01.035

References

[1] 江苏新医学院编. 中药大辞典: 上册[M]. 上海: 上海科学技术出版社, 1986: 512.
[2] 全国中草药会编组编. 全国中草药汇编: 下[M]. 北京: 人民卫生出版社, 1978: 129.
[3] 吴征镒. 新华本草刚要: 第一册[M]. 上海: 上海科学技术出版社, 1988: 369.
[4] 张伟, 黄正明, 陈晓农. 水芹总酚酸对正常小鼠免疫功能的影响[J]. 解放军药学学报, 2013, 29(1): 17-19.
[5] 刘鹃锋, 曹平良, 罗俊, 等. 水芹水提液抗心律失常的实验研究[J]. 南昌大学学报: 医学版, 2010, 50(3): 40-42.
[6] 张伟, 陈晓农, 黄正明, 等. 水芹总酚酸对人肝癌2.2.15细胞周期的影响[J]. 解放军药学学报, 2013, 29(4): 369-371.
[7] 朴日龙, 张红英. 水芹正丁醇提取物抗凝血和抗血栓形成作用的研究[J]. 食品科学, 2010, 31(7): 280-283.
[8] 张伟, 黄正明, 陈晓龙. 水芹总酚酸对正常小鼠免疫功能的影响[J]. 解放军药学学报, 2013, 29(1): 17-19.
[9] 年国侠, 黄正明, 杨新波, 等. 水芹总酚酸对小鼠CCl4肝损伤的保护作用[J]. 解放军药学学报, 2008, 24(6): 501-504.
[10] 年国侠, 黄正明, 杨新波, 等. 水芹总酚酸退黄作用的实验研究[J]. 解放军药学学报, 2009, 25(2): 124-127.
[11] 吴剑峰. 天然药物化学[M]. 北京: 人民卫生出版社, 2003: 240-244.
[12] 郭晓青, 陈晓靓, 杨春梅, 等. 紫苏叶活性成分及抗氧化性研究[J]. 食品与机械, 2014, 30(4): 178-181.
[13] 郭晓青, 吴金鸿, 周焱富, 等. 明日叶叶水溶性总黄酮提纯工艺[J]. 食品科学, 2012, 33(22): 27-32.
[14] MOHD A A, GHANYA A N, MIZATON H, et al. Hypoglycemic effect of Octomelessumatrana aqueous extract in streptozotocin-induced diabetic rats and its molecular mechanisms[J]. Asian Pacific Journal of Tropical Medicine, 2012, 11: 875-881.
[15] FAIYAZ A N S, SIDDARAJU M H, UROOJ A. Effect of Buteamonosperma Lam. Leaves and bark extracts on blood glucose in streptozotocin-induced severely diabetic rats [J]. Pharmacognosy Res, 2012, 4: 33-36.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.