Study on the antioxidant and whitening effect of rose fermented broth

Authors

ZHAO Dan, Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University, Beijing 100083, China
CAO Yufeng, Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University, Beijing 100083, China
DING Wenyu, Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University, Beijing 100083, China
WANG Changtao, Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University, Beijing 100083, China; Beijing Advanced Innovation Centre for Food Nutrition and Human Health, Beijing 100083, China
SHI Doudou, Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University, Beijing 100083, China
YU Dan, Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University, Beijing 100083, China
ZHANG Jiachan, Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University, Beijing 100083, China
LI Meng, Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University, Beijing 100083, China

Abstract

To evaluate the antioxidant, whitening effect and skin safety of rose fermented broth. Method: Rose fermented broth was acquired by fermenting saccharomyces cerevisiae with rose. The skin safety, antioxidant effect and whitening effect were evaluated. The human whole gene expression profile chip was used to explore the whitening mechanism of rose fermented broth. The results showed that the scavenging effect of rose fermented broth on DPPH radical scavenging was obvious and its inhibitory effect on the activity of extracellular tyrosinase was in direct proportional to the concentration. The intracellular tests showed that rose broth had inhibitory effect on tyrosinase activity and melanin synthesis. The gene chip detection showed that the possible mechanism of whitening was inhibiting the growth of melanoma cells by down regulating the gene expressions of NGF and FGF2 in the melanoma pathway. Human patch test showed that none positive reaction was caused by rose fermented broth. Conclusion: the rose fermented broth had a high skin safety as well as antioxidant and whitening effect. The whitening effect might be caused by down regulation of NGF and FGF2.

Publication Date

9-28-2017

First Page

141

Last Page

145,196

DOI

10.13652/j.issn.1003-5788.2017.09.030

Recommended Citation

Dan, ZHAO; Yufeng, CAO; Wenyu, DING; Changtao, WANG; Doudou, SHI; Dan, YU; Jiachan, ZHANG; and Meng, LI (2017) "Study on the antioxidant and whitening effect of rose fermented broth," Food and Machinery: Vol. 33: Iss. 9, Article 30.
DOI: 10.13652/j.issn.1003-5788.2017.09.030
Available at: https://www.ifoodmm.cn/journal/vol33/iss9/30

References

[1] 孙静, 马琳, 吕斯琦, 等. 中药发酵技术研究进展[J]. 药物评价研究, 2011, 34(1): 49-52.
[2] 施昌松. 天然活性化妆品的现状与发展趋势[J]. 日用化学品科学, 2012, 35(2): 1-5.
[3] 方燕玉. 天然活性成分在化妆品中的应用研究[D]. 北京: 北京化工大学, 2008: 1-2.
[4] 赵兴秀, 何义国, 邹伟, 等. 发酵培养基对不同方法测量透明质酸结果的影响[J]. 食品与机械, 2016, 32(2): 7-10.
[5] 贾长虹, 常丽新, 杨亚男, 等. 玫瑰叶黄酮提取及其对亚硝酸盐的清除作用[J]. 食品与机械, 2009, 25(5): 78-81.
[6] 张建成. 大马士革玫瑰精油提取和综合利用[D]. 北京: 北京化工大学, 2006: 1-3.
[7] 刘绍军, 刘畅, 张艳霞, 等. 特色玫瑰香葡萄酒发酵工艺优化[J]. 河北科技师范学院学报, 2012(1): 1-4.
[8] 林森. 浙江玫瑰醋纯种发酵技术的研究[D]. 杭州: 浙江工商大学, 2009: 8-12.
[9] 杨洋, 高航. 玫瑰樱桃复合风味发酵乳的研制[J]. 中国奶牛, 2015(5): 43-46.
[10] 莫大美, 吴荣书. 复合菌种发酵法制备玫瑰酵素工艺研究[J]. 食品工业, 2016, 37(10): 64-69.
[11] 包怡红, 刘奇, 王薇. 酿酒酵母胞外多糖发酵工艺条件优化[J]. 酿酒, 2012, 39(2): 58-62.
[12] 帕尔哈提·柔孜, 阿依姑丽·艾合麦提, 朱昆, 等. 玫瑰花瓣总黄酮和总多糖的体外抗氧化活性[J]. 食品科学, 2013, 34(11): 138-141.
[13] 白伟芳, 崔波. 玫瑰花多糖提取及抗氧化活性研究[J]. 食品与机械, 2009, 25(6): 83-86.
[14] 庄永亮, 张燕新, 唐远龙. 玫瑰蜂花粉中不同存在形态酚类物质的组成及其抑制B16黑色素瘤细胞的活性[J]. 现代食品科技, 2016, 32(8): 1-7.
[15] MARCONI A, PANZA M C, BONNET M, et al. Expression and function of neurotrophins and their receptors in human melanocytes[J]. International Journal of Cosmetic Science, 2006, 28(4): 255-261.
[16] YAAR M, GROSSMAN K, ELLER M, et al. Evidence for nerve growth factor-mediated paracrine effects in human epidermis[J]. The Journal of Cell Biology, 1991, 115(3): 821-828.
[17] IMOKAWA G. Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders[J]. Pigment Cell Research, 2004, 17(2): 96-110.
[18] BRENNER M, VINCENT J. Modifying skin pigmentation - approaches through intrinsic biochemistry and exogenous agents[J]. Drug Discovery Today Disease Mechanisms, 2008, 5(2): 189-199.
[19] 中华人民共和国卫生部. 卫监督发〔2007〕1号 化妆品卫生规范[S]. 北京: [出版者不详], 2007: 277-279.