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Abstract

The paper focuses on the changes of the ginseng’s function with radiation. Under the dose of 1~6 kGy of 60Co-γ ray, the preservation rate of fresh ginseng significantly increased by 20% to 30%, while up to 98% when combining with other method and meanwhile reduce consumption of energy, which surely has a great advantage over the general dry treatment. Besides preservation after 10 kGy irradiation ginsenoside Rb1 significantly reduced, 21 kGy irradiation resulting in the damage of C—O—H functional units of the pyran ring aldohexose and new chemical composition, 30 kGy irradiation will cause a partial conversion from ginsenoside Rb1 to ginsenoside Rg3, but at the same time vitamins and other heat-sensitive compounds have been destroyed. But because of the significant enhancement of the content of Rg1, Rg3, Rh1, Rh2, Rh4 and CK after irradiation, which can enhance immunity of body to the virus, relieve Alzheimerin mouse model by improving the pathology of amyloid and activation of PKA/CREB signaling pathway thus play a neuroprotective role; inhibit the growth of VGF, which reduce the thrombosis caused by malignant aggregation of platelets and play a role in anti-cancer; down-regulate lipogenic and inflammatory genes to alleviate the occurrence of obesity and hypercholesterolemia; promote insulin sensitivity, which improve insulin resistance, improve glucose uptake and thus reduce fast blood glucose levels in diabetic subjects. As for toxicity of ginseng after irradiation, no accumulation of toxicity, abnormal toxicity and genotoxicity was found.

Publication Date

11-28-2018

First Page

161

Last Page

166,199

DOI

10.13652/j.issn.1003-5788.2018.11.033

References

[1] 贾玉萍, 周东顺, 孙超, 等. 人参多糖对环磷酰胺的增效减毒作用[J]. 中国实验动物学报, 2013, 21(6): 61-64.
[2] 史得君, 严欢, 崔清美, 等. 人参茎叶提取物对I型糖尿病小鼠模型的影响[J]. 食品与机械, 2017, 33(7): 165-169.
[3] 罗志平, 孟兰贞, 徐远芳, 等. 60Co-γ辐照对茶花蜂花粉的杀菌效果及品质影响[J]. 食品与机械, 2015, 31(3): 150-153.
[4] 杨丹, 罗小虎, 齐丽君, 等. 电子束辐照对稻米储藏特性及品质的影响[J]. 食品与机械, 2017, 33(2): 106-110, 178.
[5] 李树锦, 金乾坤, 李晓东, 等. 浅谈食品辐照技术的研究现状[J]. 延边大学农学学报, 2012, 34(4): 362-366.
[6] 刘琼英, 邝炎华, 邓志群, 等. 60Co-γ射线辐照中药材杀虫灭菌效果及主要有效成分变化的研究[J]. 华南大学学报, 1990, 11(3): 76-84.
[7] 李玮轩. wCo-Y辐照处理对不同品种蓝莓货架期及冷藏效果的影响[D]. 沈阳: 沈阳农业大学, 2017: 6-8.
[8] 王守经, 柳尧波, 胡鹏, 等. 高能电子束辐照对小麦粉品质及面团流变学特性的影响[J]. 核农学报, 2015, 29(8): 1 517-1 524.
[9] 王锋, 哈益明, 周洪杰, 等. 辐照对食品营养成分的影响[J]. 食品与机械, 2005(5): 52-55.
[10] CAVA R, TARREGA R, RAMIREZ R, et al. Decolouration and lipid oxidation changes of vacuum-packed Iberian dry-cured loin treated with E-beam irradiation(5 kGy and 10 kGy) during refrigerated storage[J]. Innovative Food Sci, 2009(10): 495-499.
[11] 陈其勇, 吴若昕, 刘旸, 等. 电子束辐照降解人参口服液多种农药残留的可行性研究[J]. 核农学报, 2013, 27(7): 952-956.
[12] 王乃利, 姚新生, 王志学. 钴60-射线辐照鲜人参防腐对人参皂甙的影响[J]. 沈阳药学院学报, 1986, 8(4): 296.
[13] 王子文, 许德春, 杨万旗, 等. 人参辐照保鲜及毒性试验[J]. 核农学报, 1991, 5(4): 229-232.
[14] 王成方, 刘士德, 金卫东, 等. 辐照及小包装气调综合技术保鲜人参的研究[J]. 核农学报, 1992, 6(2): 125-128.
[15] 王成方, 刘士德, 金卫东, 等. 辐照加工长白山鲜人参的品质及安全性[J]. 核农学通报, 1995, 16(6): 287-290.
[16] 许德春, 王子文, 孟丽芬, 等. 鲜人参辐照保鲜工艺研究[J]. 核农学报, 1998, 12(3): 135-138.
[17] ZHAO Xiao-nan, WANG Zi-wen, XU De-chun, et al. Study on Irradiation Technique to Keep Fresh in Ginseng [J]. Acta Laser Biology Sinica, 2001, 10(3): 222-225.
[18] 孟兰贞, 罗志平, 李文革, 等. 60Co-γ辐照灭菌对三七超微粉有效成分及止血作用的影响[J]. 今日药学, 2017, 27(8): 510-513.
[19] 游强蓁, 李雪松, 贺云杰, 等. 人参等中药材辐照灭菌前后质量对比研究[J]. 天津药学, 2017, 29(5): 15-21.
[20] 黄念君, 陈世明. 不同品系小鼠在微核实验中敏感性的比较[J]. 药学通报, 1985(262): 714.
[21] 黄念君, 毕道琴, 孟建华. γ-射线辐照长白山鲜人参遗传毒性的系列研究[J]. 人参研究, 1992(3): 12-16.
[22] 陈庆隆, 黄志勇. 洋参丸辐照后的灭菌效果与品质变化[J]. 江西农业学报, 1995, 7(2): 162-165.
[23] 吴彩宣, 邓志群. 西洋参60Co辐照的贮藏效应[J]. 核农学通报, 1993, 14(1): 29-31.
[24] SUN Liang, ZHANG Mei-ping, WANG Yi, et al. Research progress in biotransformation of ginsenosides and solid state fermentation by microorganism[J]. Science and Technology of Food Industy, 2013, 34(15): 395-399.
[25] WANG Hai-jing, YAN Ming-ming, SHAO Shuai, et al. Comparison of ginseng and notoginseng on chemical composition and pharmaceutical action[J]. Ginseng Research, 2008, 21(4): 2-11.
[26] 杨佳丹, 向荣凤, 戴青, 等. 人参皂苷Rg3对模拟高原缺氧大鼠的抗疲劳效应和骨骼肌线粒体功能的影响[J]. 第三军医大学学报, 2018, 11(6).
[27] KIM J H, KWON S K, SUNG N Y, et al. Effect of gamma irradiation on the conversion of ginsenoside Rb1 to Rg3[J]. Radiation Physics and Chemistry, 2012(81): 1 128-1 131.
[28] 李鹏飞, 于婷, 严红实, 等. 人参协同作用的研究现状[J]. 食品与机械, 2013, 29(5): 252-255
[29] 韩玉刚, 王猛, 陈淑云, 等. 钴-60-γ辐照对人参制品中化学成分人参皂甙含量的影响[J]. 人参研究, 1998(4): 15-16.
[30] 芮和恺, 吴美芬, 顾慧芬, 等. 辐射杀菌对十五种中药材有效成份的影响[J]. 核技术, 1987(5): 44-51.
[31] 陈瑞珍, 戚州扬. 关于中药及其制剂辐照灭菌的效果研究[J]. 时珍国医国药, 2007, 18(1): 243-244.
[32] LI Jia-wang, SI Min-zhen. A study on the effect of irradiation on components in pns powder using fourier transform infrared (FTIR) spectrocopy[J]. Chinese Journal of Spectroscopy Laboratory, 2011, 28(6): 2 825-2 830.
[33] LI Jia-wang, SI Min-zhen. A study on the effect of irradiation on components in panax ginseng powder using fourier transform infrared (FTIR) spectrocopy[J]. The Hournal of Light Scattering, 2011, 23(1): 83-89.
[34] XIE You-liang, TONG Yu-lin, ZHAO Xue-jun, et al. Effect of irradiant sterilization on quality of american ginseng cataplasm[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2013, 19(8): 98-102.
[35] BAI Yu. Effect of gamma irradiation on the ingredients of herbs and detection analysis methods for irradiated herbs by thermoluminescence[D]. Jilin: Jilin University, 2014.
[36] 李鹏飞, 于婷, 李雪, 等. 电子束辐照对人参抗肿瘤作用的影响[J]. 核农学报, 2016, 30(8): 1 524-1 533.
[37] ZHANG Jun-ying, SUN Hyeon-jin, SONG In-ja, et al. Plant regeneration of Korean wild ginseng (Panax ginseng Meyer) mutant lines induced by γ-irradiation (60Co) of adventitious roots[J]. J Ginseng Res, 2014, 38(3): 220-225.
[38] EUNJIN P, HWANG Insun, SONG Jie-young, et al. Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice[J]. Acta Histochemica, 2011, 113(1): 19-23.
[39] JIANG Shuang, REN Da-yong, LI Jian-rui, et al. Effects of compound K on hyperglycemia and insulin resistance in rats with type 2 diabetes mellitus[J]. Fitoterapia, 2014, 95(10): 58-64.
[40] SEO Yun-soo, SHON Mi-yae, KONG Ryong, et al. Black ginseng extract exerts anti-hyperglycemic effect via modulation of glucose metabolism in liver and muscle[J]. Journal of Ethnopharmacology, 2016, 190: 231-240.
[41] FANG Fang, CHEN Xiao-chun, HUANG Tian-wen, et al. Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model[J]. Biochimica et Biophysica Acta, 2012, 1 882(2): 286-292.
[42] 杨明, 王成方, 崔云志, 等. 液藏软包装辐照保鲜西洋参皂甙含量分析[J]. 现代农业科技, 2006(6): 5, 8.
[43] DAHYE Jeong, MUHAMMAD Irfan, KIM Sung-dae, et al. Ginsenoside Rg3-enriched red ginseng extract inhibits platelet activation and in vivo thrombus formation[J]. Journal of Ginseng Research, 2017, 41(4): 548-555.
[44] LEE Kyung Hee, BAE In Young, PARK Song I, et al. Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine-fructose[J]. Journal of Ginseng Research, 2016, 40(3): 237-244.
[45] HARSHA Nagar, SUJEONG Choi,JUNG Saet-byel, et al. Rg3-enriched Korean Red Ginseng enhances blood pressure stability in spontaneously hypertensive rats[J]. Integrative Medicine Research, 2016, 5(3): 223-229.
[46] HAN Myoung-sik, HAN Im-ho, LEE Dahae, et al. Beneficial effects of fermented black ginseng and its ginsenoside 20(S)-Rg3 against cisplatin-induced nephrotoxicity in LLC-PK1 cells[J]. Journal of Ginseng Research, 2016, 40(2): 135-140.
[47] BO Ra Jeon, SU Jung Kim, SEUNG Bok Hong, et al. The inhibitory mechanism of crude saponin fraction from Korean Red Ginseng in collagen-induced platelet aggregation[J]. Journal of Ginseng Research, 2015, 39(3): 279-285.
[48] 王子文, 许德春, 孟丽芬, 等. 辐照保鲜人参药理作用的研究[J]. 核农学报, 1992, 6(1): 8-12.
[49] LEE C H, KIM J H, A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases[J]. J Ginseng Res, 2014, 38(3): 161-166.
[50] KANG J A, SONG H Y, BYUN E H. Gamma-irradiated black ginseng extract inhibits mast cell degranulation and suppresses atopicdermatitis-like skin lesions in mice[J]. Food and Chemical Toxicology, 2018, 111: 133-143.
[51] HANUMANTHA RB, REKHA S, KIM JH, et al. Ginseno-side rich fraction of Panax ginseng C. A. Meyer improve feeding behavior following radiation-induced pica in rats[J]. Fitote-rapia, 2012, 83(6): 1 144-1 150.

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