Study on the optimization on direct compression of Lycium ruthenicum Murr. submicron powder

Authors

DENG Kai, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai 810008, China; University of the Chinese Academy of Sciences, Beijing 100049, China; Key Laboratory of Tibetan Medicine Research of Qinghai Province, Xining, Qinghai 8100
DING Chenxu, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai 810008, China; Key Laboratory of Tibetan Medicine Research of Qinghai Province, Xining, Qinghai 810008, China; Key Laboratory of Tibetan Medicine Research, Xining, Qingha
SUO Yourui, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai 810008, China; Key Laboratory of Tibetan Medicine Research of Qinghai Province, Xining, Qinghai 810008, China; Key Laboratory of Tibetan Medicine Research, Xining, Qingha

Abstract

Appropriate excipients were selected for direct compression process of Lycium ruthenicum Murr. Tablets according to the powder properties were screened. The influence of different excipients was investigated based on single factor test with hardness, friability and disintegration time as comprehensive scores. Then, through the Box-Benhnken design of response surface method, the best prescription of the direct compression of Lycium ruthenicum Murr was made. The impact of the different environment on tablets quality also was detected. Conclusion: Microcrystalline cellulose SH102, anhydrous lactose, colloidal silicon were selected as excipients. powders was obtained as follows: microcrystalline cellulose SH102 content of 29.56%, anhydrous lactose content of 26.91%, colloidal silicon content of 6.24%. It was also manifested that the tablets which compression under the low temperature and low humidity had the best scores which is 0.806, and the tablets with excipients had the obvious advantages in the storage and transportation.

Publication Date

5-28-2018

First Page

204

Last Page

209

DOI

10.13652/j.issn.1003-5788.2018.05.042

Recommended Citation

Kai, DENG; Chenxu, DING; and Yourui, SUO (2018) "Study on the optimization on direct compression of Lycium ruthenicum Murr. submicron powder," Food and Machinery: Vol. 34: Iss. 5, Article 42.
DOI: 10.13652/j.issn.1003-5788.2018.05.042
Available at: https://www.ifoodmm.cn/journal/vol34/iss5/42

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