Functional components in the fruit of Gardenia jasminoides Ellis and their application

Authors

WANG Li, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
LI Na, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
LI Yan, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
QIAN Haifeng, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
ZHANG Hui, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
QI Xiguang, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China

Abstract

The components of Gardenia jasminoides Ellis and their healthy functions were summarized in this review. The relative products of the leaves and fruits were also introduced, which was helpful to the development and application of the Gardenia fruit.

Publication Date

7-28-2018

First Page

173

Last Page

178

DOI

10.13652/j.issn.1003-5788.2018.07.036

Recommended Citation

Li, WANG; Na, LI; Yan, LI; Haifeng, QIAN; Hui, ZHANG; and Xiguang, QI (2018) "Functional components in the fruit of Gardenia jasminoides Ellis and their application," Food and Machinery: Vol. 34: Iss. 7, Article 36.
DOI: 10.13652/j.issn.1003-5788.2018.07.036
Available at: https://www.ifoodmm.cn/journal/vol34/iss7/36

References

[1] 刘晓棠, 赵伯涛, 张玖, 等. 栀子的综合开发与利用[J]. 中国野生植物资源, 2008, 27(1): 19-23.
[2] OZAKI A, KITANO M, FURUSAWA N, et al. Genotoxicity of gardenia yellow and its components[J]. Food &Chemical Toxicology, 2002, 40(11): 1 603-1 610.
[3] MAILLOUX R J, ADJEITEY N K, HAARPER M E. Genipin-Induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents[J]. Plos One, 2010, 5(10): 13 289.
[4] 冯筱懿, 田婧卓, 易艳, 等. 栀子苷对大鼠的肾脏毒性作用[J]. 中国实验方剂学杂志, 2016(10): 118-121.
[5] TSAI C C, HUANG R N, SUNG H W, et al. In vitro evaluat-ion of the genotoxicity of a naturally occurring crosslinking agent (genipin) for biologic tissue fixation[J]. Journal of Biomedical Materials Research, 2000, 52(1): 58-65.
[6] 齐雅静, 顾军强, 王立, 等. 栀子果功能性成分研究进展[J]. 食品工业科技, 2013, 34(14): 363-369.
[7] XIAO Wen-ping, LI Shi-ming, WANG Si-yu, et al. Chemistry and bioactivity of Gardenia jasminoides[J]. Journal of Food & Drug Analysis, 2016, 25(1): 43-61.
[8] ZHOU Xiao-qin, BI Zhing-ming, LI Ping, et al. A new iridoid glycoside from Gardenia jasminoides[J]. 中国化学快报: 英文版, 2007, 18(10): 1 221-1 223.
[9] CHEN Quang-chen, ZHANG Wei-yun, YOUN Ui-goung, et al. Iridoid glycosides from Gardeniae Fructus for treatment of ankle sprain[J]. Phytochemistry, 2009, 70(6): 779-784.
[10] 刘武占, 范建伟, 高艳红, 等. HPLC 同时测定栀子中 8 个环烯醚萜苷类成分的含量[J]. 中国中药杂志, 2012, 37(16): 2 417-2 421.
[11] 蒋珍藕. 山栀子和水栀子中栀子甙的含量分析[J]. 广西中医药, 1995(1): 50-50.
[12] 刘和平, 许彦, 尚强, 等. 不同采收期水栀子果实中西红花苷Ⅰ、西红花苷Ⅱ和栀子苷含量变化研究[J]. 天然产物研究与开发, 2017(8): 1 333-1 338.
[13] 石凤鸣, 王文君, 陈雏, 等. 栀子指纹图谱及不同生长期西红花苷和栀子苷含量的研究[J]. 时珍国医国药, 2011, 22(8): 1 874-1 876.
[14] 邹立君. 栀子黄色素的提取及抗氧化性研究[D]. 武汉: 湖北工业大学, 2017: 1-2.
[15] YORGUN MA, RASHID K, ASLANIDS A, et al. Crocin, a plant-derived carotenoid, modulates microglial reactivity[J]. Biochemistry & Biophysics Reports, 2017, 12: 245-250.
[16] UEKUSA Y, SUGIMOTO N, SATO K, et al. ChemInform abstract: neocrocin a: a novel crocetin glycoside with a unique system for binding sugars isolated from gardenia yellow[J]. Chemical & Pharmaceutical Bulletin, 2007, 55(11): 1 643-1 646.
[17] CARMONA M, ZALACAIN A, SANCHEZ A M, et al. Crocetin esters, picrocrocin and its related compounds present in Crocus sativus stigmas and Gardenia jasminoides fruits. Tentative identification of seven new compounds by LC-ESI-MS[J]. Journal of Agricultural & Food Chemistry, 2006, 54(3): 973.
[18] 焦雁翔, 唐正中, 唐玉琴, 等. 不同叶果型栀子植株果内栀子苷和西红花苷含量分析[J]. 经济林研究, 2017, 35(3): 193-198.
[19] CHEN Yang, ZHANG Hao, LI Yi-xi, et al. Crocin and geniposide profiles and radical scavenging activity of gardenia fruits (Gardenia jasminoides, Ellis) from different cultivars and at the various stages of maturation[J]. Fitoterapia, 2010, 81(4): 269.
[20] 付小梅, 王峥涛. 西红花苷-1的稳定性研究[J]. 食品科学, 2012, 33(5): 71-73.
[21] 廖夫生, 熊魏. 栀子中熊果酸提取分离及纯化研究[J]. 食品研究与开发, 2011, 32(10): 5-8.
[22] 黎潭辉, 罗淑芳, 庄义修. HPLC法测定江西栀子中绿原酸的含量[J]. 中医临床研究, 2012, 4(7): 50-51.
[23] 闫光军, 范建伟, 苏瑞强, 等. 不同采收期栀子有机酸类成分HPLC指纹图谱[J]. 中国实验方剂学杂志, 2015, 21(11): 39-41.
[24] 唐灿, 李云鹏, 张彦燕, 等. 不同采收期对江西栀子熊果酸含量的影响[J]. 时珍国医国药, 2008, 19(8): 1 927-1 928.
[25] 康彬彬, 陈团伟, 陆丽琴, 等. 超声波辅助乙醇提取栀子绿原酸的工艺研究[J]. 东南园艺, 2013(1): 13-18.
[26] 于洋, 高昊, 戴毅, 等. 栀子属植物化学成分的研究进展[J]. 中草药, 2010, 41(1): 148-153.
[27] 张忠立, 左月明, 杨雅琴, 等. 栀子中的黄酮类化学成分研究[J]. 中国实验方剂学杂志，2013, 19(4): 299-301.
[28] KIM H J, KIM E J, SEO S H, et al. Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus[J]. Journal of Natural Products, 2006, 69(4): 600-603.
[29] 薛梅, 李炳奇, 王自军, 等. 栀子中总黄酮和多糖的微波提取与含量测定[J]. 中国现代应用药学, 2006, 23(5): 402-404.
[30] 吴祥庭, 吴明江, 王岖平, 等. 均匀设计法优化栀子总黄酮超声提取及其抗氧化研究[J]. 中国食品学报, 2012, 12(12): 66-71.
[31] 孟延发, 刘景会, 李志孝, 等. 栀子多糖的分离纯化及其基本性质[J]. 兰州大学学报: 自科版, 1993(2): 109-112.
[32] 韦性琰, 王定天. 江西栀子多糖的含量测定及比较[J]. 江西中医药大学学报, 2011, 23(5): 51-52.
[33] 韩东, 王珏, 朱兴一, 等. 响应面法优化水栀子多糖的闪式提取工艺[J]. 林产化学与工业, 2013, 33(6): 59-62.
[34] 谭小梅. 栀子苷通过抑制细胞凋亡保护糖尿病大鼠胰岛细胞[J]. 临床和实验医学杂志, 2017, 16(8): 741-743.
[35] 姚冬冬, 舒娈, 杨蕾, 等. 栀子苷降糖作用及相关机制研究[J]. 中草药, 2014, 45(8): 1 121-1 125.
[36] QIU Wen-jing, ZHOU Yang, JIANG Lei, et al. Genipin inhibits mitochondrial uncoupling protein 2 expression and ameliorates podocyte injury in diabetic mice[J]. Plos One, 2012, 7(7): 41 391.
[37] GUAN Li-li, FENG Hai-yang, GONG De-zheng, et al. Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction[J]. Experimental Gerontology, 2013, 48(12): 1 387-1 394.
[38] GHOSH S, SENGUPA A, SHARMA S, et al. Metabolic perturbations of kidney and spleen in murine cerebral malaria: (1) H NMR-based metabolomic study[J]. Plos One, 2013, 8(9): e73 113.
[39] HU Ting-ling, SHE Xiao-li, TIAN Jun-sheng, et al. Investigation on endogenous metabolitesin pancreas 1ohf diabetic ratsafter treatment by genipin through 1H-NMR-based metabolomic profiles[J]. Chinese Traditional and Herbal Drugs, 2016, 8(2): 133-138.
[40] LIU Hong-tao, HE Ju-lin, LI Wen-ming, et al. Geniposide inhibits interleukin-6 and interleukin-8 production in lipopolysaccharide-induced human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways[J]. Inflammation Research: Official Journal of the European Histamine Research Society, 2010, 59(6): 451.
[41] SHI Qing-hai, CAO Jin-jun, FANG Li, et al. Geniposide suppresses LPS-induced nitric oxide, PGE2 and inflammatory cytokine by downregulating NF-κB, MAPK and AP-1 signaling pathways in macrophages[J]. International Immunopharmacology, 2014, 20(2): 298-306.
[42] ZHANG Xie, SUN Chao-yue, ZHANG Yong-bin, et al. Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute lung injury through inhibition of TLR4-mediated NF-κB signaling pathway and MMP-9 expression[J]. Journal of Ethnopharmacology, 2016, 186: 91.
[43] WANG Jun, HOU Jin-can, ZHANG Peng, et al. Geniposide reduces inflammatory responses of oxygen-glucose deprived rat microglial cells via inhibition of the TLR4 signaling pathway[J]. Neurochem Res, 2012, 37(10): 2 235-2 248.
[44] JEON W K, HONG H Y, IM B C. Genipin up-regulates heme oxygenase-1 via PI3-kinase-JNK1/2-Nrf2 signaling pathway to enhance the anti-inflammatory capacity in RAW264.7 macrophages[J]. Archives of Biochemistry & Biophysics, 2011, 512(2): 119-125.
[45] MA Tao-tao, HUANG Cheng, ZONG Guo-jun, et al. Hepatoprotective effects of geniposide in a rat model of nonalcoholic steatohepatitis[J]. Journal of Pharmacy & Pharmacology, 2011, 63(4): 587-593.
[46] KIM S J, KIM J K, LEE D U, et al. Genipin protects lipopolysaccharide-induced apoptotic liver damage in D-galactosamine-sensitized mice[J]. European Journal of Pharmacology, 2010, 635(3): 188-193.
[47] DING Yue, ZHANG Tong, TAO Jian-sheng, et al. Potential hepatotoxicity of geniposide, the major iridoid glycoside in dried ripe fruits of Gardenia jasminoides ( Zhi-zi)[J]. Nat Prod Res, 2013, 27(10): 929-933.
[48] 胡燕珍, 罗光明, 卫军营, 等. 栀子中京尼平苷对肝脏的保护与过量毒性[J]. 中国现代中药, 2015, 17(10): 1 113-1 116.
[49] 任艳青, 田宇柔, 李琛, 等. 京尼平苷及其体内代谢产物京尼平对HepG2细胞毒性的比较及机制研究[J]. 中国药理学通报, 2016, 32(12): 1 755-1 761.
[50] TIAN Jun-sheng, CUI Yuan-lu, HU Li-min, et al. Antidepressant-like effect of genipin in mice[J]. Neuroscience Letters, 2010, 479: 236-239.
[51] CHEN Jian-li, SHI Bi-yun, XIANG Huan, et al. ¹ H NMR-based metabolic profiling of liver in chronic unpredictable mild stress rats with genipin treatment[J]. Journal of Pharmaceutical & Biomedical Analysis, 2015, 115: 150-158.
[52] TIAN Jun-sheng, SHI Bi-yun, XIANG Huan, et al. ¹H-NMR-based metabonomic studies on the anti-depressant effect of genipin in the chronic unpredictable mild stress rat model[J]. Plos One, 2013, 8(9): e75 721.
[53] WANG Qiang-song, TIAN Jun-sheng, CUI Yuan-lu, et al. Genipin is active via modulating monoaminergic transmission and levels of brain-derived neurotrophic factor (BDNF) in rat model of depression[J]. Neuroscience, 2014, 27(13): 365-373.
[54] LUO Jun, WANG Ri-kang, HUANG Zhao, et al. Synthesis of stable genipin derivatives and studies of their neuroprotective activity in PC12 cells[J]. Chemmedchem, 2012, 7(9): 1 661-1 668.
[55] KORIYAMA Y, CHIBA K, YAMAZAKI M, et al. Long-acting genipin derivative protects retinal ganglion cells from oxidative stress models in vitro and in vivo through the Nrf2/antioxidant response element signaling pathway[J]. Journal of Neurochemistry, 2010, 115(1): 79-91.
[56] YAMAZAKI M, CHIBA K. Genipin exhibits neurotrophic effects through a common signaling pathway in nitric oxide synthase-expressing cells[J]. European Journal of Pharmacology, 2008, 581(3): 255-261.
[57] 张耘实, 祁贤, 卢协勤, 等. 栀子苷对甲型H1N1流感病毒的抑制作用[J]. 中国药科大学学报, 2016, 47(2): 204-209.
[58] NAM K N, PARK Y M, JUNG H J, et al. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells [J]. European Journal of Pharmacology, 2010, 648 (1/2/3): 110.
[9] ORUC S, GONUL Y, TUNAY K, et al. The antioxidant and antiapoptotic effects of crocin pretreatment on global cerebral ischemia reperfusion injury induced by four vessels occlusion in rats[J]. Life Sci, 2016, 154: 79-86.
[60] PAPNDREOU M A, KANAKIS C D, POLISSIOU M G, et al. Inhibitory activity on amyloid-beta aggregation andantioxidant properties of Crocus sativus stigmas extractand its crocin constituents[J]. J Agric Food Chem, 2006, 54(23): 8 762-8 768.
[61] LV Bao-chang, CHEN Tao, XU Zhi-guo, et al. Crocin protects retinal ganglion cells against H₂O₂-induced damage through the mitochondrial pathway and activation of NF-κB[J]. Int J Mol Med, 2016, 37(1): 225-232.
[62] 郭斌, 范钦华, 王莉, 等. 藏红花素对糖基化终产物诱导视网膜微血管内皮细胞凋亡的影响[J]. 医学研究生学报, 2012, 25(11): 1 141-1 145.
[63] CHEN Li, QI Yun, YANG Xin-guang. Neuroprotective effects of crocin against oxidative stress induced by ischemia/reperfusion injury in rat retina[J]. Ophthalmic Res, 2015, 54(3): 157-168.
[64] VAKILI A, EINALI M R, BANDEGI A R. Protective effect of crocin against cerebral ischemia in a dose-dependent manner in a rat model of ischemic stroke[J]. Journal of Stroke & Cerebrovascular Diseases, 2014, 23(1): 106-113.
[65] JNANASHWAI S, HEMSHEKHAR M, SABTHOSH M S, et al. Crocin, a dietary colorant mitigates cyclophosphamide‐induced organ toxicity by modulating antioxidant status and inflammatory cytokines[J]. Journal of Pharmacy & Pharmacology, 2013, 65(4): 604-614.
[66] GHADRDOOST B, VAFAEIA A, RASHIDY-POUR A, et al. Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats[J]. European Journal of Pharmacology, 2011, 667(1/2/3): 222-229.
[67] AUNG H H, WANG C Z, NI M, et al. Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells[J]. Exp Oncol, 2007, 29(3): 175-180.
[68] KURATSUNE H, UMIGAI N, TAKENO R, et al. Effect of crocetin from gardenia jasminoides ellis on sleep: a pilot study[J]. Phytomedicine, 2010, 17: 840-843.
[69] SHENG Liang, QIAN Zhi-yu, ZHENG Shu-guo, et al. Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase[J]. Eur J Pharmacol, 2006, 543(1/2/3): 116-122
[70] 李宝莉, 陈雅慧, 杨暄, 等. 栀子油的提取和对中枢神经系统的作用[J]. 医学争鸣, 2008(23): 2 152-2 155.
[71] 李昊阳, 王飞运, 刘华敏, 等. 不同方法制备的栀子果油的理化性质比较[J]. 现代食品科技, 2016(9): 209-215.
[72] CAI Xiao-shuang, ZHANG Rui, GUO Ying, et al. Optimiz-ation of ultrasound-assisted extraction of gardenia fruit oil with bioactive components and their identification and quantification by HPLC-DAD/ESI-MS(2)[J]. Food & Function, 2015, 6(7): 2 194.
[73] 包亚妮, 董建青, 贺文浩, 等. 二次通用旋转组合设计法优化超临界CO₂萃取栀子油的工艺研究[J]. 中国粮油学报, 2011, 26(5): 66-70.
[74] 杨冀艳, 许世晓, 胡磊. 超声波辅助提取栀子油及其脂肪酸组成分析研究[J]. 食品科学, 2008, 29(11): 246-249.
[75] 包亚妮, 董建青, 袁芳. 超临界CO₂萃取工艺条件对栀子油脂肪酸组成及其抗氧化活性的影响[J]. 食品科学, 2011, 32(10): 12-17.
[76] 刘继平, 许海, 胡锐, 等. 栀子油对S180荷瘤小鼠肿瘤生长及胸腺、脾指数的影响[J]. 西北药学杂志, 2010, 25(2): 112-114.
[77] 张风波, 罗光明, 肖日传, 等. 栀子油对四氯化碳所致小鼠急性肝损伤的保护作用[J]. 中国油脂, 2017, 42(7): 128-131.
[78] NERI-NUMA I A, PESSOA M G, PAULINO B N, et al. Genipin: A natural blue pigment for food and health purposes[J]. Trends in Food Science & Technology, 2017, 67: 271-279.
[79] 陈旭华, 林艳华, 史亚峰, 等. 栀子黄色素在方便面中的应用研究[J]. 食品科技, 2007(12): 175-177.
[80] 王立, 段维, 张晖, 等. 一种以栀子粕和糙米为原料制备意大利面的方法: 中国, 201410706079.X [P]. 2015-03-04.
[81] 税珺, 刘新华, 陈润强, 等. 黄栀子果实开发利用价值概述[J]. 现代农业科技, 2016(13): 121-122.
[82] 郑慧英. 栀子黄色素护色剂及其制造方法: 中国, 201210014916.3[P]. 2012-12-26.
[83] 李磊, 段晋, 代刚, 等. 一种栀子黄色素护色剂及食品染色方法: 中国, 201310415745.X[P]. 2014-02-26.
[84] 郭香凤. 栀子饮料加工过程中浸提及风味调配工艺的优化[J]. 食品科学, 2009, 30(18): 63-66.
[85] 蔡小双, 段李歌, 李书艺, 等. 栀子功能性饮料制备工艺研究[J]. 中国食物与营养, 2015, 21(5): 50-54.
[86] 郑为东, 陈秋茹, 林向阳, 等. 栀子山楂保健饮料的研制[J]. 农业工程, 2014, 4(2) : 34-38.
[87] 胡程. 大越豆芋栀子植物蛋白饮料加工工艺研究[D]. 杭州: 浙江农林大学, 2015: 50-51.
[88] 刘世柏, 李旺盛, 伍有福, 等. 一种栀子茶及其制备方法: 中国, 201310742419.X[P]. 2014-04-30.
[89] 张向华. 一种甘草栀子茶及其制备方法: 中国, 01510992040.3 [P]. 2015-12-28.
[90] 腾谦. 一种栀子保健酒及其制备方法: 中国, 201710561189.5 [P]. 2017-08-29.