Study on antithrombotic effect and mechanism of lemon juice powder

Authors

XU Congyue, Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan, Hubei 430056, China
LIN Kuan, Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan, Hubei 430056, China
LI Chaoying, Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan, Hubei 430056, China
RU Qin, Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan, Hubei 430056, China

Abstract

The acute blood stasis rat model was made by injecting norepinephrine, then rats stayed in ice water bath for 4 mins. Whole blood viscosity (WBV), erythrocyte sedimentation rate(ESR), coagulation parameters, 6-keto prostaglandin F1α (6-KETO-PGF1α), thromboxane B₂ (TXB₂), endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) were measured. Results: Model group significantly up WBV and ESR level, APTT, PT, TT were decreased whereas FIB content was increased very significantly in rats of the model group, meanwhile the 6-keto-PGF1α and eNOS level were lower and TXB₂ and ET-1 level were higher. Lemon juice powder groups might down WBV and ESR level, extend PT, increase 6-keto-PGF1α level and decrease TXB₂ level, maintain the balance between 6-keto-PGF1α and TXB₂, whereas the eNOS level was higher and ET-1 level was lower than model group. Lemon juice powder has antithrombotic effect.

Publication Date

10-28-2019

First Page

108

Last Page

111

DOI

10.13652/j.issn.1003-5788.2019.10.021

Recommended Citation

Congyue, XU; Kuan, LIN; Chaoying, LI; and Qin, RU (2019) "Study on antithrombotic effect and mechanism of lemon juice powder," Food and Machinery: Vol. 35: Iss. 10, Article 21.
DOI: 10.13652/j.issn.1003-5788.2019.10.021
Available at: https://www.ifoodmm.cn/journal/vol35/iss10/21

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