Abstract
Mycotoxins are metabolized by filamentous fungi and have certain toxic effects. Based on the stable formation of human hepatocellular carcinoma cell lines (HepG2 cells), a variety of plasma proteins were secreted, which could effectively evaluate the in vitro toxic effects of mycotoxins. We reviewed the harm of major mycotoxins to food and their toxic effects on human cells, and this was significant for predicting and preventing the effects of mycotoxins on human and animal health in the future.
Publication Date
11-28-2019
First Page
223
Last Page
227
DOI
10.13652/j.issn.1003-5788.2019.11.042
Recommended Citation
Hang, YUAN
(2019)
"Research progress on hazards and toxicity of major mycotoxins in grain,"
Food and Machinery: Vol. 35:
Iss.
11, Article 40.
DOI: 10.13652/j.issn.1003-5788.2019.11.042
Available at:
https://www.ifoodmm.cn/journal/vol35/iss11/40
References
[1] WINTER G, PEREG L. A review on the relation between soil and mycotoxins: Effect of aflatoxin on field, food and finance[J]. European Journal of Soil Science, 2019, 70(4): 882-897.
[2] ESKOLA M, KOS G, ELLIOTT C T, et al. Worldwide contamination of food-crops with mycotoxins: Validity of the widely cited ‘FAO estimate’ of 25%[J]. Critical Reviews in Food Science and Nutrition, 2019, doi:10.1080/10408398.2019.1658570.
[3] YEH F S, YU M C, MO C C, et al. Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in Southern Guangxi, China[J]. Health Policy, 1989, 14(2): 2 506-2 509.
[4] CHEN Jian-guo, EGNER P A, NG D, et al. Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China[J]. Cancer Prevention Research, 2013, 6(10): 1 038.
[5] SCHOTHORST R C, VAN EGMOND H P. Report from SCOOP task 3.2.10 "collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states" -Subtask: Trichothecenes[J]. Toxicology Letters, 2004, 153(1): 133-143.
[6] YANG Wei, YU Miao, FU Juan, et al. Deoxynivalenol induced oxidative stress and genotoxicity in human peripheral blood lymphocytes[J]. Food Chem Toxicol, 2014, 64(1): 383-396.
[7] SHAR Z H, SUMBAL G A, SHERAZI S T, et al. Natural co-occurrence of aflatoxins and deoxynivalenol in poultry feed in Pakistan[J]. Food Additives & Contaminants Part B, 2014, 7(3): 162.
[8] PIETSCH C, SCHULZ C, ROVIRA P, et al. Organ damage and hepatic lipid accumulation in carp (Cyprinuscarpio L.) after feed-borne exposure to the mycotoxin, deoxynivalenol (DON)[J]. Toxins, 2014, 6(2): 756-778.
[9] 周鸿媛. 脱氧雪腐镰刀菌烯醇（DON）的多代毒性及其联合毒性研究[D]. 无锡: 江南大学, 2018: 4-5.
[10] ZHOU Hong-yuan, GEORGE S, HAY C, et al. Individual and combined effects of Aflatoxin B1, Deoxynivalenol and Zearalenone on HepG2 and RAW 264.7 cell lines[J]. Food and Chemical Toxicology, 2017, 103: 18-27.
[11] NONG Qing-qing, KOMATSU M, IZUMO K, et al. Involvement of reactive oxygen species in microcystin-LR-induced cytogenotoxicity[J]. Free Radical Research, 2007, 41(12): 1 326-1 337.
[12] SCHROEDER H W, JACQUELINE VERRETT M. Production of aflatoxin by Aspergillus wentii Wehmer [J]. Canadian Journal of Microbiology, 1969, 15(8): 895-898.
[13] MULLER M E H, KORN U. Alternaria mycotoxins in wheat-A 10 years survey in the northeast of Germany[J]. Food Control, 2013, 34(1): 191-197.
[14] MAGAN N, ALDRED D. Post-harvest control strategies: Minimizing mycotoxins in the food chain[J]. International Journal of Food Microbiology, 2007, 119(1/2): 131-139.
[15] MAGAN N, ALDRED D, MYLONA K, et al. Limiting mycotoxins in stored wheat[J]. Food Additives & Contaminants: Part A, 2010, 27(5): 644-650.
[16] WOLOSHUK C P, SHIM W B. Aflatoxins, fumonisins, and trichothecenes: A convergence of knowledge[J]. FEMS Microbiology Reviews, 2013, 37(1): 94-109.
[17] 税丕容. 食品中真菌毒素的污染与检测研究进展[J]. 现代食品, 2018(13): 130-131, 136.
[18] 侯真真, 冯志强, 林丹. 粮食及饲料中黄曲霉毒素的检测方法研究进展[J]. 粮食与饲料工业, 2016(5): 62-64, 68.
[19] 金少华, 刘柏林, 崔杰, 等. 安徽省沿淮地区沿淮地区2010～2014年粮食及其制品中真菌毒素污染状况分析[J]. 安徽预防医学杂志, 2016(5): 340-342.
[20] 谢刚. 粮食污染主要真菌毒素的研究[D]. 成都: 四川大学, 2005: 6-7.
[21] 陈帅, 于英威, 杨娟, 等. 粮食中的呕吐毒素(DON)研究进展[J]. 粮油仓储科技通讯, 2019, 35(4): 46-49, 53.
[22] DA ROCHA M E B, FREIRE F D O, MAIA F B F, et al. Mycotoxins and their effects on human and animal health[J]. Food Control, 2014, 36(1): 159-165.
[23] RICORDY R, GENSABELLA G, CACCI E, et al. Impairment of cell cycle progression by aflatoxin B1 in human cell lines[J]. Mutagenesis, 2002, 17(3): 241-249.
[24] REDDY L, ODHAV B, BHOOLA K. Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: Morphology, apoptosis and DNA damage[J]. Biological Chemistry, 2006, 387(1): 87-93.
[25] QURESHI H, HAMID S S, ALI S S, et al. Cytotoxic effects of aflatoxin B1 on human brain microvascular endothelial cells of the blood-brain barrier[J]. Medical Mycology, 2015, 53(4): 409-416.
[26] SHI Da-you, GUO Shi-ning, LIAO Shen-quan, et al. Protection of selenium on hepatic mitochondrial respiratory control ratio and respiratory chain complex activities in ducklings intoxicated with aflatoxin B1[J]. Biological Trace Element Research, 2012, 145(3): 312-317.
[27] 李文竹, 张根义, 桑亚秋. 真菌毒素(DON、AFB1)对HepG2/C3A细胞联合毒性及机理研究[J]. 食品与生物技术学报, 2017, 36(11): 1 171-1 179.
[28] TOLLESON W H, MELCHIOR W B, MORRIS S M, et al. Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatomacells[J]. Carcinogenesis, 1996, 17(2): 239-249.
[29] SANCAK D, OZDEN S. Global histone modifications in Fumonisin B1 exposure in rat kidney epithelial cells[J]. Toxicology in Vitro, 2015, 29(7): 1 809-1 815.
[30] 杜明, 刘洋, 张根义. 多指标测定黄曲霉毒素B1和伏马菌素B1联合毒性[J]. 食品工业科技, 2014, 35(13): 161-165.
[31] DING Wen-xing, SHEN Han-ming, ONG Choon-Nam. Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes[J]. Hepatology, 2000, 32(3): 547-555.
[32] GAO Wei, JIANG Li-ping, GE Lan, et al. Sterigmatocystin-induced oxidative DNA damage in human liver-derived cell line through lysosomaldamage[J]. Toxicology in Vitro, 2015, 29(1): 1-7.
[33] 刘洋. 黄曲霉毒素B1和杂色曲霉素对HepG2细胞的联合毒性[D]. 无锡: 江南大学, 2014: 3-4.
[34] THEUMER M G, HENNEB Y, KHOURY L, et al. Genotoxicity of aflatoxins and their precursors in human cells[J]. Toxicology Letters, 2018, 287(1): 100-107.
[35] 张艺兵, 鲍蕾, 褚庆华. 农产品中真菌毒素的检测分析[M]. 北京: 化学工业出版社, 2006: 83-99.
[36] QIU Si-qi, XU Zhen-zhen, SHEN Hong, et al. Effects of deoxynivalenol and zearalenone on promoting proliferation and promoting migration of cancer cells[J]. Chinese Journal of Animal Nutrition, 2018, 30(5): 1 988-1 995.
[37] ZHONG Yu-jie, JIN Cheng-ni, GAN Jing, et al. Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway[J]. Toxicon, 2017, 137(1): 106-113.
[38] ZHOU Si-ming, JIANG Li-ping, GENG Cheng-yan, et al. Patulin-induced oxidative DNA damage and p53 modulation in HepG2 cells[J]. Toxicon, 2010, 55(2/3): 390-395.
[39] MARIN S, RAMOS A J, CANO-SANCHO G, et al. Mycotoxins: Occurrence, toxicology, and exposure assessment[J]. Food and Chemical Toxicology, 2013, 60(1): 218-237.
[40] FERNANDEZ-BLANCO C, ELMO L, WALDNER T, et al. Cytotoxic effects induced by patulin, deoxynivalenol and toxin T2 individually and in combination in hepatic cells (HepG2)[J]. Food and Chemical Toxicology, 2018, 120: 12-23.
[41] JUAN-GARCIA A, JUAN C, MANYES L, et al. Binary and tertiary combination of alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol on HepG2 cells: Toxic effects and evaluation of degradation products[J]. Toxicology in Vitro, 2016, 34: 264-273.
[42] YOSHIZAWA T, TAKEDA H, OHI T. Structure of a novel metabolite from deoxynivalenol, a tricho-thecenemycotoxin, in animals[J]. Journal of the Agricultural Chemical Society of Japan, 1983, 47(9): 2133-2135.
[43] MAYER E, NOVAK B, SPRINGLER A, et al. Effects of deoxynivalenol (DON) and its microbial biotransformation product deepoxy-deoxynivalenol (DOM-1) on a trout, pig, mouse, and human cell line[J]. Mycotoxin Research, 2017, 33(4): 297-308.