Abstract
The mice in the treatment group were administrated with the BEP at doses of 200, 400, and 800 mg/(kg BW·d) for 30 consecutive days. The liver injury model was established by intraperitoneal injection of CCl4. The alanine transaminase (ALT), aspartate transaminase (AST) contents in serum, and superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and glutathione (GSH) levels in liver were measured. Meanwhile, a hepatic pathological examination was conducted. The results of this study showed that Boletus edulis polysaccharides could, to some extent, protect mice from CCl4-induced liver injury. In addition, Boletus edulis polysaccharides significantly prevent the increase in liver index spleen index, serum ALT, AST, and liver MDA levels, caused by CCl4 in mice. Boletus edulis polysaccharides could also markedly increase the activities of liver SOD, GSH-Px, GSH. Among the tested doses, 800 mg/(kg BW·d) showed the best effect. Histopathological examinations further confirmed these results.
Publication Date
12-28-2019
First Page
141
Last Page
145
DOI
10.13652/j.issn.1003-5788.2019.12.026
Recommended Citation
Qiaoran, ZHENG; Heng, ZHANG; Wenfeng, LI; Wen, TAO; Feng, ZHOU; and Xiaoxu, GAO
(2019)
"Effect of Boletus edulis polysaccharides on liver protection to CCl4-induced acute hepatic damage mice,"
Food and Machinery: Vol. 35:
Iss.
12, Article 26.
DOI: 10.13652/j.issn.1003-5788.2019.12.026
Available at:
https://www.ifoodmm.cn/journal/vol35/iss12/26
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