Abstract
Diabetic zebrafish model was established quickly by combination of 20 g/L glucose solution immersing and 10% cholesterol feeding for 20 days. The model established was used to evaluate the in vivo hypoglycemic activity of 3 000～100 Da AKEH. The effects of it on physicochemical indexes such as DPP-IV activity, glucose, triglyceride, cholesterol and expression levels of relative gene such as Insa, Glucagon and Pck1 of diabetic zebrafish were investigated. The results showed that the physicochemical index and blood glucose related gene expression level of the 1.35 g/L and 2.7 g/L concentrations were not significant difference. 3 000～100 Da AKEH of 5.4 g/L could be reduced the level of physicochemical index, significantly inhibited DPP-IV activity, the expression level of Glucagon and Pck1 gene and improved Insa expression level. Therefore, 3 000～100 Da AKEH has certain hypoglycemic effects.
Publication Date
6-28-2019
First Page
24
Last Page
29
DOI
10.13652/j.issn.1003-5788.2019.06.004
Recommended Citation
Wei, JI; Chaohua, ZHANG; Kalueff, ALLANV; and Cai, SONG
(2019)
"Establishment of diabetic zebrafish model and evaluation of hypoglycemic activity of antarctic krill enzymatic hydrolysates,"
Food and Machinery: Vol. 35:
Iss.
6, Article 4.
DOI: 10.13652/j.issn.1003-5788.2019.06.004
Available at:
https://www.ifoodmm.cn/journal/vol35/iss6/4
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