Effects of leucine and α-ketoglutarate on the weight, serum, visceral organ of mice

Authors

JIN Shunshun, Institute of Subtropical Agriculture, Chinese Academy of Science, Changsha, Hunan 410125, China; Key Lab Agro-Ecology Processing Subtropical Region, Chinese Academy of Science, Changsha, Hunan 410125, China; University of Chinese Academy of Science, Beiji
YAO Kang, Institute of Subtropical Agriculture, Chinese Academy of Science, Changsha, Hunan 410125, China
YIN Yulong, Institute of Subtropical Agriculture, Chinese Academy of Science, Changsha, Hunan 410125, China; Key Lab Agro-Ecology Processing Subtropical Region, Chinese Academy of Science, Changsha, Hunan 410125, China; University of Chinese Academy of Science, Beiji
KANG Baoju, College of Animal Science and Technology, Hunan Agriculture University, Changsha, Hunan 410128, China
LI Yuying, Institute of Subtropical Agriculture, Chinese Academy of Science, Changsha, Hunan 410125, China; Key Lab Agro-Ecology Processing Subtropical Region, Chinese Academy of Science, Changsha, Hunan 410125, China; University of Chinese Academy of Science, Beiji
WANG Peng, Institute of Subtropical Agriculture, Chinese Academy of Science, Changsha, Hunan 410125, China; Key Lab Agro-Ecology Processing Subtropical Region, Chinese Academy of Science, Changsha, Hunan 410125, China; University of Chinese Academy of Science, Beiji

Abstract

Forty male C57BL/6 mice aged 4 weeks were selected and randomly divided into 4 groups. Mice in control groups drank normal water, while those in the experimental groups were treated 1.0% α-ketoglutarate acid (group Ⅰ), or 1.8% leucine (group Ⅱ), or 1.8% leucine and 1.0% α-ketoglutarate acid (group Ⅲ) via drinking water. The experimental lasted 35 days. The results showed as follows: ① The growth performance of group Ⅲ was 8.7%, 10.1%, and 10.4% lower than that of the groups control,ⅠandⅡ, respectively； ② Serum albumin in group Ⅲ was significantly higher than that of the groups control,ⅠandⅡ(P<0.05)； ③ The cardiac index of group Ⅲ increased by 19.3%, 13.6%, and 15.2%, respectively, compared with groups control,ⅠandⅡ； ④ The abdominal fat index of group Ⅲ was 24.1%, 10.0%, and 6.7% lower than that of groups control,ⅠandⅡ, the cross-sectional area of the gastrocnemius muscle of group Ⅲ was 46.9%, 20.2%, 27.9% higher than that of groups control,ⅠandⅡ, respectively. In summary, the combination of leucine and α-ketoglutaric acid can reduce the body weight of mice, strengthen the use of fat by organs, and increase the cross-sectional area of gastrocnemius muscle fibers.

Publication Date

8-28-2019

First Page

172

Last Page

176

DOI

10.13652/j.issn.1003-5788.2019.08.032

Recommended Citation

Shunshun, JIN; Kang, YAO; Yulong, YIN; Baoju, KANG; Yuying, LI; and Peng, WANG (2019) "Effects of leucine and α-ketoglutarate on the weight, serum, visceral organ of mice," Food and Machinery: Vol. 35: Iss. 8, Article 32.
DOI: 10.13652/j.issn.1003-5788.2019.08.032
Available at: https://www.ifoodmm.cn/journal/vol35/iss8/32

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