Study on the hypoglycemic effect of dandelion extract on type 2 diabetic rats

Authors

Shuang YAN, Department of Traditional Chinese Medicine, School of Medicine, Yanbian University, Yanji, Jilin 133000 , China
Guang-yao LI, Department of Traditional Chinese Medicine, School of Medicine, Yanbian University, Yanji, Jilin 133000 , China
Cong-shu DAI, Department of Traditional Chinese Medicine, School of Medicine, Yanbian University, Yanji, Jilin 133000 , China
Hao-zhen CUI, Department of Traditional Chinese Medicine, School of Medicine, Yanbian University, Yanji, Jilin 133000 , China
Zhen-yu LIU, Department of Traditional Chinese Medicine, School of Medicine, Yanbian University, Yanji, Jilin 133000 , China
Chang-qing LIN, Department of Traditional Chinese Medicine, School of Medicine, Yanbian University, Yanji, Jilin 133000 , China

Abstract

Objective: To study the hypoglycemic effect of dandelion extract on type 2 diabetes (T2DM) rats. Methods: High-fat and high-sugar feed and streptozotocin (STZ) were used to establish type 2 diabetic rat model. The blank normal group, model group, dandelion high-dose group (400 mg/kg) and dandelion low-dose group (200 mg/kg) were set up in the experiment, positive group (150 mg/kg). Fasting blood glucose (FBG), glucose tolerance level (OGTT), insulin resistance (FINS) and insulin sensitivity (HOMA-IR) were measured in T2DM rats, and TC, TG, ALT, AST, SOD, GSH, CAT, MDA related indicators were measured. Results: Compared with the model group, the FBG, FINS and HOMA-IR of T2DM rats treated with dandelion extract were significantly reduced (P＜0.05), and the levels of TC, TG, ALT and AST were also significantly reduced (P＜0.01), SOD, GSH, CAT increased significantly (P＜0.01), MDA significantly decreased (P＜0.01). Conclusion: Dandelion extract can improve insulin resistance, increase the antioxidant leveland improve lipid metabolism in T2DM rats, thereby exerting a hypoglycemic efficacy.

Publication Date

2-18-2023

First Page

138

Last Page

142

DOI

10.13652/j.issn.1003-5788.2020.11.027

Recommended Citation

YAN, Shuang; LI, Guang-yao; DAI, Cong-shu; CUI, Hao-zhen; LIU, Zhen-yu; and LIN, Chang-qing (2023) "Study on the hypoglycemic effect of dandelion extract on type 2 diabetic rats," Food and Machinery: Vol. 36: Iss. 11, Article 27.
DOI: 10.13652/j.issn.1003-5788.2020.11.027
Available at: https://www.ifoodmm.cn/journal/vol36/iss11/27

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