Effects of a formula containing Vitamin B on ameliorates anxious/depression-like behaviors in an C57BL/6 mice model

Authors

ZHU Xi-ping, College of Food Science and Technology, South China University of Technology, Guangzhou,Guangdong 510640 , China
LI Wen-zhi, Infinitus, ﹝China﹞ Co., Ltd., Jiangmen, Guangdong 529156 , China
TAO Qian, Infinitus, ﹝China﹞ Co., Ltd., Jiangmen, Guangdong 529156 , China
HE Wen-jiang, Infinitus, ﹝China﹞ Co., Ltd., Jiangmen, Guangdong 529156 , China
CUI Chun, College of Food Science and Technology, South China University of Technology, Guangzhou,Guangdong 510640 , China ；Guangdong Weiwei Technology Co., Ltd., Guangzhou, Guangdong 510641 , China

Abstract

Investigated effects of vitamin B complex TRP peptides and SOD on the anti-oxidative activity in brain tissue, serum inflammatory factor levels and reverse anxious/depression-like behaviors. Vitamin B complex TRP peptide and SOD (V_B3︰ V_B6︰TRP peptide︰SOD = 2︰10︰3︰4; VBPS) high, medium and low gavage doses were 260, 195, 130 mg/(kg·d), respectively. Studies showed that VBPS could reverse the anxious/depression-like behaviors and the slow body weight gain, with VBPS at a high dose being more effective. VBPS showed to control the effects of serum inflammatory cytokines (TNF-α, IL-6, IL-1β and IFN-γ), decrease malondialdehyde (MDA) levels and increase superoxide dismutase (SOD), catalase (CAT), nitric oxide synthase (NOS) activity. In addition, VBPS induced down-regulation of TRP–KYN metabolism and up-regulation of KYN–NAD⁺ metabolism. In summary, results from animal experiments showed that VBPS had a significant anti-anxious depression effects as evidenced by anti-inflammatory, anti-oxidation, reversed behavioral dysfunctions and bodyweight of mice treated with VBPS compared to the anxious depression control mice. It is proved that consume VBPS diets can induce significant beneficial effects on anxious depression.

Publication Date

3-28-2020

First Page

166

Last Page

172

DOI

10.13652/j.issn.1003-5788.2020.03.032

Recommended Citation

Xi-ping, ZHU; Wen-zhi, LI; Qian, TAO; Wen-jiang, HE; and Chun, CUI (2020) "Effects of a formula containing Vitamin B on ameliorates anxious/depression-like behaviors in an C57BL/6 mice model," Food and Machinery: Vol. 36: Iss. 3, Article 32.
DOI: 10.13652/j.issn.1003-5788.2020.03.032
Available at: https://www.ifoodmm.cn/journal/vol36/iss3/32

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