In vitro antioxidant, α-glucosidase and acetylcholinesterase inhibitory activities of the shell oxtracts from Cyclobalanopsis glauca

Authors

RU Yue-rong, College of Life Sciences, Southwest Forestry University, Kunming, Yunnan 650224 , China
YANG Jin-mei, College of Life Sciences, Southwest Forestry University, Kunming, Yunnan 650224 , China
SHEN Wen-jie, College of Life Sciences, Jiangxi Normal University, Nanchang, Jiangxi 330022 , China
WANG Jun-min, College of Life Sciences, Southwest Forestry University, Kunming, Yunnan 650224 , China
GUO Lei, College of Life Sciences, Southwest Forestry University, Kunming, Yunnan 650224 , China
FAN Fang-yu, College of Life Sciences, Southwest Forestry University, Kunming, Yunnan 650224 , China
SHA Xiao-mei, College of Life Sciences, Jiangxi Normal University, Nanchang, Jiangxi 330022 , China
WANG Zhen-xing, College of Life Sciences, Southwest Forestry University, Kunming, Yunnan 650224 , China ；College of Life Sciences, Jiangxi Normal University, Nanchang, Jiangxi 330022 , China

Abstract

The antioxidant activity, hypoglycemic potential, and Alzheimer's therapeutic potential of Cyclobalanopsis glauca Shells were investigated in this study. The hydroxyl radical scavenging ability, DPPH radical scavenging ability, superoxide anion radical scavenging ability, and ABTS radical scavenging ability were used as an indicator for evaluating the in vitro antioxidant activity of Cyclobalanopsis glauca Shells Extract (CGSE). Then the α-glucosidase inhibitory ability of CGSE was evaluated by the fluorimetry assay, and the acetylcholinesterase (AChE) inhibitory ability of CGSE was evaluated by the modified Ellman method. Experimental results showed that CGSE had strong antioxidant activity, their IC₅₀ values of hydroxyl radical scavenging activity, DPPH radical scavenging activity, ABTS radical scavenging activity, and superoxide anion scavenging activity were (273.43±9.55), (8.31±0.08), (26.43±0.14) μg/mL, and (1 662.37±30.71) μg Trolox/g·DW, respectively. The IC₅₀ values toward α-glucosidase of CGSE was (24.81±1.99) μg/mL, which were significantly higher than that of positive control acarbose. CGSE also showed a certain AChE inhibitory ability with the IC₅₀ value of (422.29±25.26) μg/mL.

Publication Date

4-28-2020

First Page

157

Last Page

161

DOI

10.13652/j.issn.1003-5788.2020.04.029

Recommended Citation

Yue-rong, RU; Jin-mei, YANG; Wen-jie, SHEN; Jun-min, WANG; Lei, GUO; Fang-yu, FAN; Xiao-mei, SHA; and Zhen-xing, WANG (2020) "In vitro antioxidant, α-glucosidase and acetylcholinesterase inhibitory activities of the shell oxtracts from Cyclobalanopsis glauca," Food and Machinery: Vol. 36: Iss. 4, Article 29.
DOI: 10.13652/j.issn.1003-5788.2020.04.029
Available at: https://www.ifoodmm.cn/journal/vol36/iss4/29

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