Abstract
A variety of bioactivities induding papaya alkaloids, rutin, benzyl isothiocyanate, carotenoids in Papaya (Carica Papaya L.) were investigated in this study. Some of these compounds exhibited a broad array of pharmacological activities in gastrointestinal protection, hepatoprotective effect, anti-inflammatory, weight loss and beauty, anti-cancer, anti-bactericidal and antioxidation properties. This review summarizes the research progress of main bioactive substances, anticancer functions in different parts of papaya, and its wide application prospects in food industry, pharmaceutical industry and health care industry were proposed.
Publication Date
5-28-2020
First Page
221
Last Page
226
DOI
10.13652/j.issn.1003-5788.2020.05.041
Recommended Citation
Shuang-ling, XIAO and Jie, TENG
(2020)
"Research progress on chemical constituents and anticancer activities in different parts of papaya,"
Food and Machinery: Vol. 36:
Iss.
5, Article 41.
DOI: 10.13652/j.issn.1003-5788.2020.05.041
Available at:
https://www.ifoodmm.cn/journal/vol36/iss5/41
References
[1] 熊月明,刘友接,林燕金.番木瓜栽培及利用[M].北京:中国农业出版社,2012:23.
[2] KRISHNA K,PARIDHAVI M,PATEL J A.Review on nutritional,medicinal and pharmacological properties of papaya(Carica papaya Linn.)[J].Natural Product Radiance,2008,7(4):364-373.
[3] MILIND P,GURDITTA.Basketful benefits of papaya[J].International Research Journal of Pharmacy,2011,2(7):6-12.
[4] PREETEE J,PRADEEP K,SINGH V K,et al.Carica papaya Linn:A potential source for various health problems[J].Journal of Pharmacy Research,2010,3(5):998-1 003.
[5] MING Ray,HOU Shao-bin,FENG Yun,et al.The draft genome of the transgenic tropical fruit tree papaya(Carica papaya Linnaeus)[J].Nature,2008,452(7 190):991-996.
[6] HEWITT H,WHITTLE S,LOPEZ S,et al.Topical use of papaya in chronic skin ulcer therapy in Jamaica[J].The West Indian Medical Journal,2000,49(1):32-33.
[7] SOIB H H,ISMAIL H F,HUSIN F,et al.Bioassay-guided different extraction techniques of Carica papaya(Linn.)leaves on in Vitro wound-healing activities[J].Molecules,2020,25(3):517.
[8] LIM T K.Edible medicinal and non-medicinal plants[J].The Netherlands,2012,1(4):285-292.
[9] OTSUKI N,DANG N H,KUMAGAI E,et al.Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects[J].Journal of Ethnopharmacology,2010,127(3):760-767.
[10] LUCAS T P.The most wonderful tree in the world:The papaw tree(Carica Papaia)[M].[S.l.]:Carter-Watson Company,2016:189.
[11] AMENTA R,CAMARDA L,DI STEFANO V,et al.Traditional medicine as a source of new therapeutic agents against psoriasis[J].Fitoterapia,2000(71):S13-S20.
[12] 廖灿杰.番木瓜籽蛋白质功能性质及其应用的研究[D].武汉:华中农业大学,2019:1-4.
[13] NGUYEN T T T,SHAW P N,PARAT M O,et al.Anticancer activity of Carica papaya:A review[J].Molecular Nutrition & Food Research,2013,57(1):153-164.
[14] 汪修意,胡长鹰,虞兵,等.番木瓜中生物活性成分的研究进展[J].食品工业科技,2013,34(18):394-398.
[15] HUANG Wu-yang,CAI Yi-zhong,ZHANG Yan-bo.Natural phenolic compounds from medicinal herbs and dietary plants:Potential use for cancer prevention[J].Nutrition and Cancer,2009,62(1):1-20.
[16] VAN BREEMEN R B,PAJKOVIC N.Multitargeted therapy of cancer by lycopene[J].Cancer Letters,2008,269(2):339-351.
[17] SOOBRATTEE M A,BAHORUN T,ARUOMA O I.Chemopreventive actions of polyphenolic compounds in cancer[J].Biofactors,2006,27(1/2/3/4):19-35.
[18] TANAKA T,SHNIMIZU M,MORIWAKI H.Cancer chemoprevention by carotenoids[J].Molecules,2012,17(3):3 202-3 242.
[19] WAHLE K W J,BROWN I,ROTONDO D,et al.Plant phenolics in the prevention and treatment of cancer[M]//Bio-Farms for Nutraceuticals.[S.l.]:Springer,Boston,MA,2010:36-51.
[20] 朱明月.番木瓜种子提取物异硫氰酸苄酯对肝癌细胞恶性行为的影响及其作用机制[D].海口:海南大学,2015:5-10.
[21] ZHANG Yue-sheng.Cancer-preventive isothiocyanates:measurement of human exposure and mechanism of action[J].Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis,2004,555(1/2):173-190.
[22] MELLO V J,GOMES M T R,LEMOS F O,et al.The gastric ulcer protective and healing role of cysteine proteinases from Carica candamarcensis[J].Phytomedicine,2008,15(4):237-244.
[23] MORIMOTO C.Therapeutic Co Ltd(YSTH-Non-standard)Toudai Tlo Ltd(TOUDNon-standard)Morimoto C(MORI-Individual)Dang NH(DANG-Individual),Cancer prevention and treating composition for preventing,ameliorating,or treating solid cancers,eg lung,or blood cancers,eg lymphoma,comprises components extracted from brewing papaya:USA,WO2006004226-A1[P].2008-10-14.
[24] 秦贞苗,赖伟勇,张俊清,等.番木瓜籽油的超临界萃取工艺及其脂肪酸组成分析[J].广州化工,2015,43(18):50-51.
[25] RAHMAT A,ROSLI R,ZAIN W,et al.Antiproliferative activity of pure lycopene compared to both extracted lycopene and juices from watermelon(Citrullus vulgaris)and papaya(Carica papaya)on human breast and liver cancer cell lines[J].Journal of Medical Science,2002,2(2):55-58.
[26] NAKAMURA Y,YOSHIMOTO M,MURATA Y,et al.Papaya seed represents a rich source of biologically active isothiocyanate[J].Journal of Agricultural and Food Chemistry,2007,55(11):4 407-4 413.
[27] GARCA-SOLS P,YAHIA E M,MORALES-TLALPAN V,et al.Screening of antiproliferative effect of aqueous extracts of plant foods consumed in Mexico on the breast cancer cell line MCF-7[J].International Journal of Food Sciences and Nutrition,2009,60(S6):32-46.
[28] JAYAKUMAR R,KANTHIMATHI M S.Inhibitory effects of fruit extracts on nitric oxide-induced proliferation in MCF-7 cells[J].Food Chemistry,2011,126(3):956-960.
[29] HIROSE M,YAMAGUCHI T,KIMOTO N,et al.Strong promoting activity of phenylethyl isothiocyanate and benzyl isothiocyanate on urinary bladder carcinogenesis in F344 male rats[J].International Journal of Cancer,1998,77(5):773-777.
[30] ADEBIYI A,ADAIKAN P G,PRASAD R N V.Papaya(Carica papaya)consumption is unsafe in pregnancy:Fact or fable?Scientific evaluation of a common belief in some parts of Asia using a rat model[J].British Journal of Nutrition,2002,88(2):199-203.
[31] 朱明月,李伟,鲁琰,等.番木瓜种子提取物异硫氰酸苄酯对肝癌细胞凋亡的影响[J].世界华人消化杂志,2014,22(16):2 277-2 284.
[32] 周骊,李泽友,沈文涛,等.番木瓜种子中异硫氰酸苄酯(BITC)的抑癌试验[J].热带生物学报,2012,3(2):130-134.
[33] KHUZHAEV V U,ARIPOVA S F.Pseudocarpaine from Carica papaya[J].Chemistry of Natural Compounds,2000,36(4):418-418.
[34] RIVERA-PASTRANA D M,YAHIA E M,GONZÁLEZ-AGUILAR G A.Phenolic and carotenoid profiles of papaya fruit(Carica papaya L.)and their contents under low temperature storage[J].Journal of the Science of Food and Agriculture,2010,90(14):2 358-2 365.
[35] JIAO Zhe,DENG Jian-chao,LI Gong-ke,et al.Study on the compositional differences between transgenic and non-transgenic papaya(Carica papaya L.)[J].Journal of Food Composition and Analysis,2010,23(6):640-647.
[36] AFZAN A,ABDULLAH N R,HALIM S Z,et al.Repeated dose 28-days oral toxicity study of Carica papaya L.leaf extract in Sprague Dawley rats[J].Molecules,2012,17(4):4 326-4 342.
[37] NISA F Z,ASTUTI M,MURDIATI A,et al.Anti-proliferation and apoptosis induction of aqueous leaf extract of Carica papaya L.on human breast cancer cells MCF-7[J].Pakistan Journal of Biological Sciences,2017(20):36-41.
[38] HADADI S A,LI Hai-wen,RAFIE R,et al.Anti-oxidation properties of leaves,skin,pulp,and seeds extracts from green papaya and their anti-cancer activities in breast cancer cells[J].Journal of Cancer Metastasis Treat,2018,4:25.
[39] HUSIN F,YA'AKOB H,RASHID S N A,et al.Cytotoxicity study and antioxidant activity of crude extracts and SPE fractions from Carica papaya leaves[J].Biocatalysis and Agricultural Biotechnology,2019,19:101-130.
[40] 赵毅蒙.番木瓜籽中异硫氰酸苄酯的抑菌机理[D].天津:天津科技大学,2018.
[41] 孔永强,郑华,张弘,等.我国异硫氰酸酯(ITCs)的开发现状及利用前景[J].化工进展,2011,30(增刊1):291-294.
[42] LI Meng-sun,ZHU Ming-yue,LI Wei,et al.270P Benzyl-isothiocyanate induces apoptosis and inhibits migration and invasion of hepatocellular carcinoma cells in vitro[J].Annals of Oncology,2016,27(S 9):1-2.
[43] TSAI T F,LIN Jin-feng,LIAO Piao-chun,et al.304 Benzyl isothiocyanate induces reactive oxygen species-mediated autophagy and apoptosis in human prostate cancer cells[J].European Urology Supplements,2014,13(1):e304-e304.
[44] NAKAMURA Y,MIYOSHI N.Cell death induction by isothiocyanates and their underlying molecular mechanisms[J].Biofactors,2006,26(2):123-134.
[45] 杜依登.番木瓜籽异硫氰酸酯的制备及其特性研究[D].天津:天津科技大学,2014:14-21.
[46] 朱华平,赵毅蒙,李超,等.番木瓜籽中异硫氰酸苄酯抗癌抑菌功能研究进展[J].现代食品科技,2018,34(3):270-275.
[47] 秦溱.番木瓜的应用价值与开发利用研究进展[J].食品工业,2017,38(1):234-237.