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Abstract

Based on purine metabolism and the pathway of uric acid, four kinds of uric acid-lowering modes and mechanisms of natural bioactive compounds were summarized, mainly analyzed the uric acid-lowering modes and research results of natural extracts, protein enzymatic hydrolysates, polypeptides, probiotics and other active compounds. It is provided guidance for the development of medicinal resources, medical auxiliary food and natural anti-gout drugs.

Publication Date

2-18-2023

First Page

210

Last Page

216

DOI

10.13652/j.issn.1003-5788.2020.08.036

References

[1] FAM A G.Gout,diet,and the insulin resistance syndrome[J].Journal of Rheumatology,2002,29(7):1 350-1 355.
[2] HOCHBERG M C,SILMAN A J,SMOLEN J S,et al.Rheumatology[M].3rd ed.New York:Mosby,2003:6-18.
[3] 黎青勇.核桃源降尿酸肽靶向抑制黄嘌呤氧化酶活性的构效机制研究[D].广州:华南理工大学,2018.
[4] GIBSON T.Hyperuricemia,gout and the kidney[J].Current Opinion in Rheumatology,2012,24(2):127-131.
[5] 金方,杨虹.降血清尿酸益生菌株的筛选和降血清尿酸机理的探索[J].微生物学通报,2018,45(8):154-166.
[6] RULE A D,BERGSTRALH E J,MELTON L J,et al.Kidney stones and the risk for chronic kidney disease[J].Clinical Journal of the American Society of Nephrology,2009,4(4):804-811.
[7] VUPPUTURI S,SOUCIE J M,MCCLELLAN W,et al.History of kidney stones as a possible risk factor for chronic kidney disease[J].Annals of Epidemiology,2004,14(3):222-228.
[8] KRAMER H M,CURHAN G.The association between gout and nephrolithiasis:The national health and nutrition examination survey III,1988-1994[J].American Journal of Kidney Diseases,2002,40(1):37-42.
[9] FESSEL W J.Renal outcomes of gout and hyperuricemia[J].The AmericanJournal of Medicine,1979,67(1):74-82.
[10] MEHMOOD A,ZHAO Lei,WANG Cheng-tao,et al.Management of hyperuricemia through dietary polyphenols as a natural medicament:A comprehensive review[J].Critical Reviews in Food Science & Nutrition,2017,59(9):1 433-1 455.
[11] 中国口腔清洁护理用品工业协会.牙膏生产技术概论:上册[M].北京:中国轻工业出版社,2014:140.
[12] 方北曙,李翠莲,黄中培,等.牛乳中黄嘌呤氧化酶研究综述[J].食品与机械,2006,22(1):93-96.
[13] 闾洁,孙超,李飞.中药活性成分降尿酸作用机制研究进展[J].中国药理学通报,2018(1):19-22.
[14] BALDISSERA M D,SOUZA C F,DOLESKI P H,et al.Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected withIchthyophthirius multifiliis:The influence of these enzymes on inflammatory and oxidative status[J].Journal of Fish Diseases,2018,41(2):263-268.
[15] KAMINSKY Y,KOSENKO E.AMP deaminase and adenosine deaminase activities in liver and brain regions in acute ammonia intoxication and subacute toxic hepatitis[J].Brain Res,2010,1 311:175-181.
[16] ZHANG Xin-guo,SUN Qiao-yun,TANG Peng,et al.A new mixed inhibitor of adenosine deaminase produced by endophytic Cochliobolus sp.from medicinal plant seeds[J].Folia Microbiologica,2020,65(2):1-10.
[17] HARRISON R.Structure and function of xanthine oxidoreductase:Where are we now?[J].Free Radical Biology & Medicine,2002,33(6):774-797.
[18] CANTU-MEDELLIN N,KELLEY EE.Xanthine oxidoreductase-catalyzed reactive species generation:A process in critical need of reevaluation[J].Redox Biology,2013,1(1):353-358.
[19] OLIVEIRA E P D,BURINI R C.High plasma uric acid concentration:Causes and consequences[J].Diabetology & Metabolic Syndrome,2012,4(1):12.
[20] MANDAL A K,MOUNT D B.The molecular physiology of uric acid homeostasis[J].Annual Review of Physiology,2015,77(77):323-345.
[21] XU Liu-qing,SHI Ying-feng,ZHUANG Shou-gang,et al.Recent advances on uric acid transporters[J].Oncotarget,2017,8(59):100 852-100 862.
[22] LEAL-PINTO E,TAO W,RAPPAPORT J,et al.Molecular cloning and functional reconstitution of a urate transporter/channel[J].Journal of Biological Chemistry,1997,272(1):617-625.
[23] HOQUE M T,CONSEIL G,COLE S P C.Involvement of NHERF1 in apical membrane localization of MRP4 in polarized kidney cells[J].Biochemical & Biophysical Research Communications,2009,379(1):60-64.
[24] 刘璐,青玉凤,周京国.尿酸盐转运蛋白1在高尿酸血症/痛风中的研究进展[J].医学综述,2016,22(6):36-39.
[25] AUGUSTIN R,CARAYANNOPOULOS M O,DOWD L O,et al.Identification and characterization of human glucose transporter-like protein-9(GUJT9):Alternative splicing alters trafficking[J].Journal of Biological Chemistry,2004,279(16):16 229-16 236.
[26] ANZAI N,ICHIDA K,JUTABHA P,et al.Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1(SLC2A9)in Humans[J].Journal of Biological Chemistry,2008,283(40):26 834-26 838.
[27] REGINATO A M,MOUNT D B,YANG I,et al.The genetics ofhyperuricaemia and gout[J].Nat Rev Rheumatol,2012,8(10):610-621.
[28] KIM D W,CURTIS-LONG M J,YUK H J,et al.Quantitative analysis of phenolic metabolites from different parts of Angelica keiskei by HPLC-ESI MS/MS and their xanthine oxidase inhibition[J].Food Chemistry,2014,153(15):20-27.
[29] 史珅,张荣涛,尚小玉,等.葛根提取物对高尿酸血症大鼠血清尿酸的影响[J].食品科技,2014,39(2):216-220.
[30] WANG Ya-jie,ZHANG Guo-wen,PAN Jun-hui,et al.Novel insights into the inhibitory mechanism of kaempferol on xanthine oxidase[J].Journal of Agricultural & Food Chemistry,2015,63(2):526-534.
[31] 周琦,张翀,于栋华,等.穿山龙总皂苷对高尿酸血症的降尿酸及细胞抗炎作用研究[J].中华中医药杂志,2013,28(5):1 444-1 448.
[32] NICIFOROVIC N,ABRAMOVIC H.Sinapic acid and its derivatives:Natural sources and bioactivity[J].Comprehensive Reviews in Food Science & Food Safety,2014,13(1):34-51.
[33] ISHAQ M,MEHMOOD A,REHMAN AU,et al.Antihyperuricemic effect of dietary polyphenol sinapic acid commonly present in various edible food plants[J].Journal of Food Biochemistry,2020,DOI:10.1111/jfbc.13111.
[34] MEHMOOD A,ZHAO Lei,WANG Cheng-tao,et al.Stevia residue extract increases intestinal uric acid excretion via interactions with intestinal urate transporters in hyperuricemic mice[J].Food & Function,2019,10(12):7 900-7 912.
[35] LI Shao-peng,LI Lan-zhou,YAN Han,et al.Anti-gouty arthritis and anti-hyperuricemia properties of celery seed extracts in rodent models[J].Molecular Medicine Reports,2019,20(5):4 623-4 633.
[36] ZHANG Zi-cheng,SU Guan-hua,LUO Chun-li,et al.Effects of anthocyanins from purple sweet potato(Ipomoea batatas L.cultivar Eshu No.8)on the serum uric acid level and xanthine oxidase activity in hyperuricemic mice[J].Food & Function,2015,6(9):3 045-3 055.
[37] CHEN Lin,LI Ming,WU Jin-long,et al.Effect of lemon water soluble extract on hyperuricemia in a mouse model[J].Food & Function,2019,10(9):6 000-6 008.
[38] WU Xiao-hui,ZHANG Jun,WANG Shu-qing,et al.Riparoside B and timosaponin J,two steroidal glycosides from Smilax riparia,resist to hyperuricemia based on URAT1 in hyperuricemic mice[J].Phytomedicine,2014,21(10):1 196-1 201.
[39] LEE Y S,SUNG Y Y,YUK H J,et al.Anti-hyperuricemic effect of Alpinia oxyphylla seed extract by enhancing uric acid excretion in the kidney[J].Phytomedicine,2019,62:152975.
[40] ZHU Li-ran,DONG Yi-fan,NA Sha,et al.Saponins extracted from Dioscorea collettii rhizomes regulate the expression of urate transporters in chronic hyperuricemia rats[J].Biomedicine & Pharmacotherapy,2017,93:88-94.
[41] METHATHAM T,BOONCHUEN P,JAREE P,et al.Antiviral action of the antimicrobial peptide ALFPm3 from Penaeus monodon against white spot syndrome virus[J].Developmental & Comparative Immunology,2017,69:23-32.
[42] LEE H,VILIAN A E,KIM J Y,et al.Design and development of caffeic acid conjugated with Bombyx mori derived peptide biomaterials for anti-aging skin care applications[J].RSC Ad-vances,2017,7(48):30 205-30 213.
[43] AMEER K,SHAHBAZ H M,KWON J H.Green extraction methods for polyphenols from plant matrices and their byproducts:A review[J].Comprehensive Reviews in Food Science & Food Safety,2017,16(2):295-315.
[44] 刘洋.海洋鱼抗痛风肽的制备及其作用机理研究[D].广州:华南理工大学,2014:43-50.
[45] HE Wei-wei,SU Guo-wan,SUN Dong-xiao,et al.In vivo anti-hyperuricemic and xanthine oxidase inhibitory properties of tuna protein hydrolysates and its isolated fractions[J].Food Chemistry,2019,272:453-461.
[46] LI Qing-yong,KANG Xiao-yan,SHI Chuan-chao,et al.Moderation of hyperuricemia in rats via consuming walnut protein hydrolysate diet and identification of new antihyperuricemic peptides[J].Food & Function,2018,9(1):107-116.
[47] LI Qing-yong,SHI Chuan-chao,WANG Min,et al.Tryptophan residue enhances in vitro walnut protein-derived peptides exerting xanthine oxidase inhibition and antioxidant activities[J].Journal of Functional Foods,2019,53:276-285.
[48] NONGONIERMA A B,MOONEY C,SHIELDS D C,et al.Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides[J].Food Chemistry,2013,141(1):644-653.
[49] WAN Hai-tao,HAN Jiao-jiao,TANG Sha-sha,et al.Comparisons of protective effects between two sea cucumber hydrolysates against diet induced hyperuricemia and renal inflammation in mice[J].Food & Function,2020,11(1):1 074-1 086.
[50] CHEN Rong-jane,CHEN Mei-huei,CHEN Yen-lin,et al.Evaluating the urate-lowering effects of different microbial fermented extracts in hyperuricemic models accompanied with a safety study[J].Journal of Food and Drug Analysis,2017,25(3):597-606.
[51] 陈晓真,陈彦霖,许薰尹,等.新颖的鼠李糖乳杆菌菌株及其用于抑制黄嘌呤氧化酶及治疗痛风的代谢产物:中国,201510519096.7[P].2016-04-20.
[52] LI Ming,YANG Dian-bin,MEI Lu,et al.Screening and characterization of purine nucleoside degrading lactic acid bacteria isolated from Chinese sauerkraut and evaluation of the serum uric acid lowering effect in hyperuricemic rats[J].Plos One,2014,9(9):e105577.
[53] BAI Yun-huan,JIANG Ya-fen,JIANG Yun-sheng.Lactobacillus bulgaricus mutants decompose uremic toxins[J].Ren Fail,2014,36:790-794.

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