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Abstract

In this study, the latest research results of droplet microfluidics, membrane emulsification, and coaxial electrospray preparation of double emulsion are introduced, and their advantages and disadvantages are compared and analyzed. The limitation of microfluidic prepared double emulsion industrialization and its related research was pointed out. The latest research results of double emulsion in the fields of food, cosmetics, and biomedicine were reviewed, and the advantages and prospects of double emulsion applications prospected.

Publication Date

2-18-2023

First Page

1

Last Page

11

DOI

10.13652/j.issn.1003-5788.2020.09.001

References

[1] SILVA W,TORRES G M F,OYARZUN A F,et al.Double emulsions as potential fat replacers with gallic acid and quercetin nanoemulsions in the aqueous phases[J].Food Chemistry,2018,253:71-78.
[2] KHEYNOOR N,HOSSEINI S M H,YOUSEFI G H,et al.Encapsulation of vitamin C in a rebaudioside-sweetened model beverage using water in oil in water double emulsions[J].LWT-Food Science and Technology,2018,96:419-425.
[3] SHADDEL R,HESARI J,AZADMARD D S,et al.Double emulsion followed by complex coacervation as a promising method for protection of black raspberry anthocyanins[J].Food Hydrocolloids,2018,77:803-816.
[4] LEE H,CHOI C H,ABBASPOURRAD A,et al.Encapsulation and enhanced retention of fragrance in polymer microcapsules[J].ACS Appl Mater Interfaces,2016,8(6):4 007-4 013.
[5] CASANOVA F,SANTOS L.Encapsulation of cosmetic active ingredients for topical application:A review[J].Journal of Microencapsulation,2016,33(1):1-17.
[6] MAHRHAUSER D S,FISCHER C,VALENTA C.Double emulsions based on silicone-fluorocarbon-water and their skin penetration[J].International Journal of Pharmaceutics,2016,498(1/2):130-133.
[7] LIU Liu,YANG Jian-yang,JU Xiao-jie,et al.Monodisperse core-shell chitosan microcapsules for pH-responsive burst release of hydrophobic drugs[J].Soft Matter,2011,7(10):4 821-4 827.
[8] KIM B,LEE S,KIM S H.Double-emulsion-templated anisotropic microcapsules for pH-triggered release[J].Advanced Materials Interfaces,2018,5(4):10.
[9] HUSSAIN M R,DEVI R R,MAJI T K.Controlled release of urea from chitosan microspheres prepared by emulsification and cross-linking method[J].Iranian Polymer Journal,2012,21(8):473-479.
[10] CHÁVEZ-PÁEZ M,QUEZADA C M,IBARRA-BRACAMONTES L,et al.Coalescence in double emulsions[J].Langmuir,2012,28(14):5 934-5 939.
[11] IQBAL M,ZAFAR N,FESSI H,et al.Double emulsion solvent evaporation techniques used for drug encapsulation[J].International Journal of Pharmaceutics,2015,496:173-90.
[12] 付冬文,朱雨晴,成策,等.食品级W/O/W双重乳液的稳定性及应用研究进展[J].食品工业科技,2019,40(11):323-333.
[13] GARTI N,BISPERINK C.Double emulsions:Progress and applications[J].Current Opinion in Colloid & Interface Science,1998,3(6):657-667.
[14] XIAO Jie,LU Xuan-xuan,HUANG Qing-rong.Double emulsion derived from kafirin nanoparticles stabilized Pickering emulsion:Fabrication,microstructure,stability and in vitro digestion profile[J].Food Hydrocolloids,2017,62:230-238.
[15] KIM S,KIM K,CHOI S Q.Controllable one-step double emulsion formation via phase inversion[J].Soft Matter,2018,14(7):1 094-1 099.
[16] 林欣雨,李瑶琦,周瑾,等.壳聚糖/盐酸小檗碱缓释微球的制备[J].中成药,2019,41(11):2 560-2 566.
[17] VANDERGRAAF S,SCHROEN C,BOOM R.Preparation of double emulsions by membrane emulsification a review[J].Journal of Membrane Science,2005,251(1/2):7-15.
[18] JOSCELYNE S M,TRAGAIDH G.Membrane emulsification:A literature review[J].Journal of Membrane Science,2000,169(1):107-117.
[19] VAN DER GRAAF S,SCHROEN C,BOOM R.Preparation of double emulsions by membrane emulsification:A review[J].Journal of Membrane Science,2005,251(1/2):7-15.
[20] NA Xiang-ming,GUO Jian-jun,LI Tong,et al.Double emulsion-templated single-core PLGA microcapsules with narrow size distribution and controllable structure by using premix membrane emulsification[J].Chem Nano Mat,2020,6(7):1 059-1 062.
[21] VLADISAVLJEVIC G T,KHALID N,NEVES M A,et al.Industrial lab-on-a-chip:Design,applications and scale-up for drug discovery and delivery[J].Advanced Drug Delivery Reviews,2013,65(11/12):1 626-1 663.
[22] MATSUMOTO S,KITA Y,YONEZAWA D.An attempt at preparing water-in-oil-in-water multiple-phase emulsions[J].Journal of Colloid & Interface Science,1976,57(2):353-361.
[23] JANGIR P,JANA A K.CFD simulation of droplet splitting at microfluidic T-junctions in oil-water two-phase flow using conservative level set method[J].Journal of the Brazilian Society of Mechanical Sciences and Engineering,2019,41(2):16.
[24] TADROS T,IZQUIERDO P,ESQUENA J,et al.Formation and stability of nano-emulsions[J].Advances in Colloid and Interface Science,2004,108/109:303-318.
[25] LI M K,FOGLER H S.Acoustic emulsification,Part 2:Breakup of the large primary oil droplets in a water medium[J].Journal of Fluid Mechanic,1978,88(3):513.
[26] LEONG T S H,ZHOU M,KUKAN N,et al.Preparation of water-in-oil-in-water emulsions by low frequency ultrasound using skim milk and sunflower oil[J].Food Hydrocolloids,2017,63(2):685-695.
[27] KHADEM B,SHEIBAT-OTHMAN N.Theoretical and experimental investigations of double emulsion preparation by ultrasonication[J].Industrial & Engineering Chemistry Research,2019,58(19):8 220-8 230.
[28] LEONG T S H,ONG L,GAMLATH C J,et al.Formation of cheddar cheese analogues using canola oil and ultrasonication:A comparison between single and double emulsion systems[J].International Dairy Journal,2020,105:10.
[29] NEUBAUER R L,VONNEGUT B.Supplement to "production of monodisperse liquid particles by electrical atomization"[J].Journal of Colloid Science,1953,8(5):551-552.
[30] MARIN A G,LOSCERTALES I G,MARQUEZ M,et al.Simple and double emulsions via coaxial jet electrosprays[J].Physical Review Letters,2007,98(1):014502.
[31] SONG Yang,CHAN Yau-kei,MA Qing-ming,et al.All-aqueous electrosprayed emulsion for templated fabrication of cytocompatible microcapsules[J].ACS Appl Mater Interfaces,2015,7(25):13 925-13 933.
[32] AKAMATSU K,KANASUGI S,NAKAO S,et al.Membrane-integrated glass capillary device for preparing small-sized water-in-oil-in-water emulsion droplets[J].Langmuir,2015,31(25):7 166-7 172.
[33] KOTHANDARAMAN A,HARKER A,VENTIKOS Y,et al.Novel preparation of monodisperse microbubbles by integrating oscillating electric fields with microfluidics[J].Micromachines-Basel,2018,9(10):19.
[34] MATSUMOTO S.Development of W/O/W-type dispersion during phase inversion of concentrated W/O emulsions[J].Journal of Colloid & Interface Science,1983,94(2):362-368.
[35] DING S,SERRA C A,VANDAMME T F,et al.Double emulsions prepared by two-step emulsification:History,state-of-the-art and perspective[J].Journal Control Release,2019,295:31-49.
[36] GAO Fei,SU Zhi-guo,WANG Ping,et al.Double emulsion templated microcapsules with single hollow cavities and thickness-controllable shells[J].Langmuir,2009,25(6):3 832-3 838.
[37] GAO Wei,CHENG Yong-ping.Microencapsulation of solid cores to prepare double emulsion droplets by microfluidics[J].International Journal of Heat and Mass Transfer,2019,135:158-163.
[38] THOMPSON B,MOVSESIAN N,CHENG C,et al.Modular microfluidics for double emulsion formation[J].Methods in Cell Biology,2018,148:161-176.
[39] LIAN Zheng,CHAN Yue,LUO Yang,et al.Microfluidic formation of highly monodispersed multiple cored droplets using needle-based system in parallel mode[J].Electrophoresis,2020,41(10/11):891-901.
[40] KANAI T,TSUCHIYA M.Microfluidic devices fabricated using stereolithography for preparation of monodisperse double emulsions[J].Chemical Engineering Journal,2016,290:400-404.
[41] HUYNH M C,THANH D T,LE T T T,et al.Advances in colloidal dispersions:A review[J].Journal of Dispersion Science and Technology,2019,41(4):479-494.
[42] IQBAL M,VALOUR J P,FESSI H,et al.Preparation of biodegradable PCL particles via double emulsion evaporation method using ultrasound technique[J].Colloid and Polymer Science,2015,293(3):861-873.
[43] LEONG T S H,ZHOU Mei-fang,ZHOU Darren,et al.The formation of double emulsions in skim milk using minimal food-grade emulsifiers:A comparison between ultrasonic and high pressure homogenisation efficiencies[J].Journal of Food Engineering,2018,219:81-92.
[44] BUDHWANI K I,DETTMANN M A,SALEH M N,et al.Nano and microbubble systems for on-demand cancer drug delivery[J].Current Nanoscience,2018,14(1):33-41.
[45] CHU Liang-yin,UTADA A S,SHAH R K,et al.Controllable monodisperse multiple emulsions[J].Angew Chem-Int Edit,2007,46(47):8 970-8 974.
[46] 林晓瑛.花色苷双重皮克林乳液的制备及其稳定性研究[D].广州:华南理工大学,2019:6.
[47] DIEP T T,DAO T P,VU H T,et al.Double emulsion oil-in water-in oil(O/W/O)stabilized by sodium caseinate and k-carrageenan[J].Journal of Dispersion Science and Technology,2018,39(12):1 752-1 757.
[48] BENICHOU A,ASERIN A,GARTI N.O/W/O double emulsions stabilized with WPI-polysaccharide conjugates[J].Colloids and Surfaces A,2007,297(1/2/3):211-220.
[49] LUTZ R,ASERIN A,WICKER L,et al.Double emulsions stabilized by a charged complex of modified pectin and whey protein isolate[J].Colloids Surf B Biointerfaces,2009,72(1):121-127.
[50] O'REGAN J,MULVIHILL D M.Sodium caseinate-maltodextrin conjugate stabilized double emulsions:Encapsulation and stability[J].Food Research International,2010,43(1):224-231.
[51] SEDDARI S,MOULAI-MOSTEFA N.Formulation and characterization of double emulsions stabilized by sodium caseinate-xanthan mixtures:Effect of pH and biopolymer concentration[J].Journal of Dispersion Science and Technology,2013,36(1):51-60.
[52] 刘杏念,王凌,李斌,等.重质碳酸钙稳定的O/W型Pickering乳液及其粒度效应研究[J].食品与机械,2019,35(4):20-25.
[53] WANKHEDE V P,SHARMA P,HUSSAIN S A,et al.Structure and stability of W1/O/W2 emulsions as influenced by WPC and NaCl in inner aqueous phase[J].Journal of Food Science and Technology,2020,57(9):3 482-3 492.
[54] KIM Shin-hyun,KIM Jin-woong,CHO Jun-cheol,et al.Correction:Double-emulsion drops with ultra-thin shells for capsule templates[J].Lab Chip,2017,17(3):567.
[55] VIAN A,REUSE B,AMSTAD E.Scalable production of double emulsion drops with thin shells[J].Lab Chip,2018,18(13):1 936-1 942.
[56] ROMANOWSKY M B,ABATE A R,ROTEM A,et al.High throughput production of single core double emulsions in a parallelized microfluidic devic[J].Lab Chip,2012,12(4):802-807.
[57] EGGERSDORFER M L,ZHENG W,NAWAR S,et al.Tandem emulsification for high-throughput production of double emulsions[J].Lab Chip,2017,17(5):936-942.
[58] BAUER W A,FISCHLECHNE M,ABELL C,et al.Hydrophilic PDMS microchannels for high-throughput formation of oil-in-water microdroplets and water-in-oil-in-water double emulsion[J].Lab Chip,2010,10(14):1 814-1 819.
[59] KONG L,LEVIN A,TOPRAKCIOGLU Z,et al.Lipid-stabilized double emulsions generated in planar microfluidic devices[J].Langmuir,2020,36(9):2 349-2 356.
[60] ZHANG Jia,XU Wen-hua,XU Feng-ying,et al.Microfluidic droplet formation in co-flow devices fabricated by micro 3D printing[J].Journal of Food Engineering,2020,290:110-212.
[61] 尚贤丹.基于液滴微流控的乳液自动生成与监测装置[D].南京:东南大学,2016:12.
[62] 张道森,王姗姗,何冠楠,等.微流控液滴光学检测系统的仿真与实验[J].微纳电子技术,2018,55(5):371-379.
[63] HOLTZE C.Large-scale droplet production in microfluidic devices-an industrial perspective[J].Journal of Physics D-Applied Physics,2013,46(11):9.
[64] SUN He-jia,ZHENG Hui,TANG Qi-ming,et al.Monodisperse alginate microcapsules with spatially confined bioactive molecules via microfluid-generated W/W/O Emulsions[J].ACS Appl Mater Interfaces,2019,11(40):37 313-37 321.
[65] DATTA S S,ABBASPOURRAD A,AMSTAD E,et al.25th anniversary article:Double emulsion templated solid microcapsules:Mechanics and controlled release[J].Advanced Material,2014,26(14):2 205-2 218.
[66] SUN Bing-jie,SHUM Ho-cheung,HOLTZE C,et al.Microfluidic melt emulsification for encapsulation and release of actives[J].ACS Appl Mater Interfaces,2010,2(12):3 411-3 416.
[67] NIE He-min,DONG Zheng-guo,ARIFIN D Y,et al.Core/shell microspheres via coaxial electrohydrodynamic atomization for sequential and parallel release of drugs[J].Journal of Biomedical Materials Research:Part A,2010,95(3):709-716.
[68] EL KADRI H,OVERTON T,BAKALIS S,et al.Understanding and controlling the release mechanism of Escherichia coli in double W1/O/W2 emulsion globules in the presence of NaCl in the W2 phase[J].RSC Advances,2015,127(5):105 098-105 110.
[69] COFRADES S,BOU R,FLAIZ L,et al.Bioaccessibility of hydroxytyrosol and n-3 fatty acids as affected by the delivery system:Simple,double and gelled double emulsions[J].Journal of Food Science and Technology,2017,54(7):1 785-1 793.
[70] WANG Jun,SHI A M,AGYEI D,et al.Formulation of water-in-oil-in-water(W/O/W)emulsions containing trans-resveratrol[J].RSC Advances,Rsc Adv,2017,57(7):35 917-35 927.
[71] JIMENEZ-MARTIN E,ANTEQUERA ROJAS T,GHARSALLAOUI A,et al.Fatty acid composition in double and multilayered microcapsules of ω-3 as affected by storage conditions and type of emulsions[J].Food Chemistry,2016,194(M1):476-486.
[72] ILYASOGLU B H,NEHIR S E.Preparation and characterization of double emulsions for saltiness enhancement by inhomogeneous spatial distribution of sodium chloride[J].LWT-Food Science and Technology,2019,101:229-235.
[73] SANTOS M G,BOZZA F T,THOMAZINI M,et al.Microencapsulation of xylitol by double emulsion followed by complex coacervation[J].Food Chemistry,2015,171:32-39.
[74] BISWAL A K,HARIPRASAD P,SAHA S.Efficient and prolonged antibacterial activity from porous PLGA microparticles and their application in food preservation[J].Materials Science & Engineering C,Materials for Biological Applications,2020,108:110496.
[75] ESKILDSEN P A P,KHALID N,KOBAYASHI I,et al.Microencapsulation of betanin in monodisperse W/O/W emulsions[J].Food Research International,2018,109:489-496.
[76] LIU Jin-ning,TAN Yun-bing,ZHOU Hua-lu,et al.Protection of anthocyanin-rich extract from pH-induced color changes using water-in-oil-in-water emulsions[J].Journal of Food Engineering,2019,254(8):1-9.
[77] EISINAIT V,LESKAUSKAIT D,PUKALSKIEN M,et al.Freeze-drying of black chokeberry pomace extract-loaded double emulsions to obtain dispersible powders[J].Journal of Food Science,2020,85(3):628-638.
[78] PAULO F,SANTOS L.Microencapsulation of caffeic acid and its release using a W/O/W double emulsion method:Assessment of formulation parameters[J].Drying Technology,2018,37(8):950-961.
[79] HOPPEL M,REZNICEK G,KAEHLIG H,et al.Topical delivery of acetyl hexapeptide-8 from different emulsions:Influence of emulsion composition and internal structure[J].European Journal of Pharmaceutical Sciences,2015,68:27-35.
[80] HU Cai-biao,GU Cheng-yu,FANG Qiao,et al.Transdermal solid delivery of epigallocatechin-3-gallate using self-double-emulsifying drug delivery system as vehicle:Formulation,evaluation and vesicle-skin interaction[J].Journal of Biomaterials Applications,2016,30(7):1 080-1 091.
[81] LIAO Rick,PON J,CHUNGYOUN M,et al.Enzymatic protection and biocompatibility screening of enzyme-loaded polymeric nanoparticles for neurotherapeutic applications[J].Biomaterials,2020,257:120238.
[82] WU N,OAKESHOTT J G,EASTON C J,et al.A double-emulsion microfluidic platform for in vitro green fluorescent protein expression[J].Journal of Micromechanics and Microengineering,2011,21(5):054032.
[83] PAN Cheng-tang,HWANG Ye-maw,LIN Yu-min,et al.Development of polycaprolactone microspheres with controllable and uniform particle size by uniform design experiment in emulsion progress[J].Sensors and Materials,2019,31(2):311-318.
[84] CARDENAS-BAILON F,OSORIO-REVILLA G,GALLARDO-VELAZQUEZ T.Microencapsulation of insulin using a W/O/W double emulsion followed by complex coacervation to provide protection in the gastrointestinal tract[J].Journal of Microencapsulation,2015,32(3):308-316.
[85] JIN Jau-liau,HOOK S,PRESTIDGE C A,et al.A lipid based multi-compartmental system:Liposomes-in-double emulsion for oral vaccine delivery[J].European Journal of Pharmaceutics & Biopharmaceutics,2015,97:15-21.
[86] CHAN H F,MA S,TIAN J,et al.High-throughput screening of microchip-synthesized genes in programmable double-emulsion droplets[J].Nanoscale,2017,9(10):3 485-3 495.
[87] BROWER K K,CARSWELL-CRUMPTON C,KLEMM S,et al.Double emulsion flow cytometry with high-throughput single droplet isolation and nucleic acid recovery[J].Lab Chip,2020,20(12):2 062-2 074.
[88] HO K K,LEE L M,LIU A P.Mechanically activated artificial cell by using microfluidics[J].Scientific Reports,2016,6:32912.
[89] VLEUGEL M,ROTH S,GROENENDIJK C F,et al.Reconstitution of basic mitotic spindles in spherical emulsion droplets[J].Journal of Visualized Experiments,2016(114):12.
[90] SUN Rui,XIA Qiang.In vitro digestion behavior of(W1/O/W2)double emulsions incorporated in alginate hydrogel beads:Microstructure,lipolysis,and releas[J].Food Hydrocolloids,2020,107:105950.
[91] CUI Jian-xia,SUN Chang-jiao,WANG An-qi,et al.Dual-functionalized pesticide nanocapsule delivery system with improved spreading behavior and enhanced bioactivity[J].Nanomaterials Basel,2020,10(2):13.
[92] ZHAO Yong-liang,LIU Jun-li,CHEN Zhi,et al.Hybrid nanostructured particles via surfactant-free double miniemulsion polymerization[J].Nature Communications,2018,9(1):1 918.
[93] LAMONT K,MARANGONI A G,PENSINI E.'Emulsion locks' for the containment of hydrocarbons during surfactant flushing[J].Journal of Environmental Sciences,2020,90:98-109.

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