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Abstract

The aging mice model were built by subcutaneous injection of D-galactose. Different content of L-linalool essential oil (2.5%, 5.0% and 7.5%) was applied to the depilated skin of the back of aging mice for 30 days, and vitamin E was used as positive control. The mice's autonomous activities were monitored, and the distribution of wrinkles on the back skin was observed. The activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) were detected in the serum and skin of the drug application site, and the content of water and hydroxyproline (Hyp) in the skin was also detected. The results showed that L-linalool essential oil could improve the autonomous activity of aging mice and reduce skin wrinkles. 5.0% L-linalool essential oil was found most effective, which was significantly different from the aging model group (P<0.05). The results showed that L-linalool had significant antioxidant and anti-skin aging activities in mice. Scavenging radicals and reducing lipid peroxidation might be one of its anti-aging mechanisms.

Publication Date

2-28-2021

First Page

169

Last Page

172,185

DOI

10.13652/j.issn.1003-5788.2021.02.029

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