Abstract
Objective:This study aimed to establish an efficient and accurate method for the determination of total iodine in milk powder by microwave digestion combining with inductively coupled plasma mass spectrometry (ICP-MS). Methods:Firstly, 0.2 mL of precipitant and 5 mL of ultrapure water were added for mixing and standing, and then 5 mL of nitric acid was added for microwave digestion. After cooling, the volume was fixed to 35 mL with ultrapure water, and then 10 mL of ammonia, 1 mL of stabilizer and 50 μL of TritonX-100 were added in sequence, avoiding the iodine loss. Results:The detection limit was 0.044 mg/kg,while iodine presented favorable linearity in the range of 0~20 μg/L with correlation coefficient (r) of 0.999 9. The precision of the method (RSD %) was less than 5%, and the spiked recoveries of real samples is 90.2% ~ 107.7%. The measured values of various standard substances are consistent with the labeled values. The iodine content of the same milk powder was similar to that of GB 5009.267—2020. Conclusion:The method showed the advantages of high efficiency, good recovery and accurate for the determination of iodine contents in milk powder, ensures personnel safety and reduces instrument maintenance cost.
Publication Date
11-23-2022
First Page
50
Last Page
54
DOI
10.13652/j.spjx.1003.5788.2022.90188
Recommended Citation
Jia-jun, ZHU; Liang, LI; Shuang, HE; and Jing-zhou, CHEN
(2022)
"Determination of iodine in milk powder by combing microwave digestion with inductively coupled plasma mass spectrometry,"
Food and Machinery: Vol. 38:
Iss.
10, Article 9.
DOI: 10.13652/j.spjx.1003.5788.2022.90188
Available at:
https://www.ifoodmm.cn/journal/vol38/iss10/9
References
[1] LEY D,TURCK D.Iodine supplementation:Is there a need?[J].Current Opinion in Clinical Nutrition & Metabolic Care,2021,24（3）:265-270.
[2] UMESH K,MADHULIKA K,NEHA S,et al.Iodine nutrition status amongst neonates in Kangra district,Himachal Pradesh[J].Journal of Trace Elements in Medicine and Biology,2014,28（3）:351-353.
[3] 马南希,林志楠,刘国良.碘过多病的发生、特征及处理特点[J].实用糖尿病杂志,2020,16（6）:2-4.MA N X,LIN Z N,LIU G L.Occurrence,characteristics and treatment characteristics of iodine excess disease[J].Journal of Practical Diabetology,2020,16（6）:2-4.
[4] 孙凯峰.HPLC-ICP-MS测定奶粉中不同形态碘的分析方法研究及ICP-MS同时测定奶粉中8种元素的方法优化[D].上海:上海海洋大学,2015:28-30.SUN K F.Studies on determination of different forms of iodine in formula by HPLC-ICP-MS and optimization of determine 8 different elements in formula by ICP-MS[D].Shanghai:Shanghai Ocean University,2015:28-30.
[5] 邓宁,李林林,徐正,等.婴幼儿配方奶粉中碘含量的检测方法[J].中国果菜,2019,39（7）:33-36.DENG N,LI L L,XU Z,et al.Detection methods of iodine content in infant formula milk powder[J].China Fruit & Vegetable,2019,39（7）:33-36.
[6] 曹叶中,蔡文.气相色谱法检测婴幼儿奶粉中碘含量方法的优化[J].安徽农业科学,2020,48（23）:223-225.CAO Y Z,CAI W.Optimization of gas chromatography method for detecting iodine content in infant milk powder[J].Anhui Agricultural Science,2020,48（23）:223-225.
[7] HU M H,CHEN H Y,JIANG Y,et al.Headspace single-drop microextraction coupled with gas chromatography electron capture detection of butanone derivative for determination of iodine in milk powder and urine[J].Chemical Papers,2013,67（10）:1 255-1 261.
[8] 李静,王雨,梁立娜.混合模式色谱柱离子色谱法同时测定奶粉中的碘离子和硫氰酸根[J].色谱,2010,28（4）:422-425.LI J,WANG Y,LIANG L N.Simultaneous determination of iodide and thiocyanate in powdered milk using ion chromatography with mixed mode column[J].Chinese Journal of Chromatography,2010,28（4）:422-425.
[9] 徐署东,李卫东,赵立胜,等.湿法消解砷铈催化分光光度法测定奶粉中碘含量的方法研究[J].安徽预防医学杂志,2016,22（4）:222-224,228.XU S D,LI W D,ZHAO L S,et al.Determination of iodine content in milk powder by wet digestion arsenic cerium catalytic spectrophotometry[J].Anhui Journal of Preventive Medicine,2016,22（4）:222-224,228.
[10] 代秀霞,田友华,徐薇,等.分光光度法测定食盐中碘含量的最优条件研究[J].广州化工,2020,48（11）:116-118.DAI X X,TIAN Y H,XU W,et al.Study on optimal conditions for the determination of iodine in salt by spectrophotometry[J].Guangzhou Chemical Industry,2020,48（11）:116-118.
[11] 卢丽,王岚,谢湘娜,等.BS ISO 20647婴儿配方奶粉和成人营养配方奶粉—总碘的测定—电感耦合等离子体质谱法（ICP-MS）[J].食品安全质量检测学报,2017,8（8）:3 161-3 168.LU L,WANG L,XIE X N,et al.BS ISO 20647 Infant formula and adult nutritional formula-determination of total iodine-inductively coupled plasma mass spectrometry（ICP-MS）[J].Journal of Food Safety and Quality Inspection,2017,8（8）:3 161-3 168.
[12] VITORIA H C,MORGANA D,JULIANO S B,et al.Successive digestions for pre-concentration and ultra-trace determination of Br and I by plasma-based atomic spectrometry and ion chromatography[J].Microchemical Journal,2019,147:239-244.
[13] ALAHMAD W,KRAIYA C,VARANUSUPAKUL P,et al.Gel electromembrane microextraction followed by ion chromatography for direct determination of iodine in supplements and fortified food samples:Green chemistry for food analysis[J].Food Chemistry,2021,358:129857.
[14] HO-SANG S,YUN-SUK O S,JUN-HWAN K,et al.Trace level determination of iodide,iodine and iodate by gas chromatography-mass spectrometry[J].Journal of Chromatography A,1996,732（2）:327-333.
[15] 袁波,徐红斌,孙凯峰,等.水提法提取—电感耦合等离子体质谱法测定婴幼儿配方奶粉中的碘[J].食品与机械,2015,31（2）:130-133.YUAN B,XU H B,SUN K F,et al.Determination on iodine content in infant formula by ICP-MS with water extraction[J].Food & Machinery,2015,31（2）:130-133.
[16] 李宗芮,张文皓,张帅,等.超声水提法-ICP-MS检测配方乳粉中碘的含量[J].食品安全质量检测学报,2014,5（12）:3 898-3 902.LI Z R,ZHANG W H,ZHANG S,et al.Determination of iodine in powdered formulas by inductively coupled plasma-mass spectrometry-the extraction with water by ultrasonic[J].Journal of Food Safety and Quality Inspection,2014,5（12）:3 898-3 902.
[17] 刘列钧,李秀维,李淑华,等.碱灰化砷铈催化分光光度法测定鲜奶及奶粉中碘含量[J].中国地方病防治杂志,2006（2）:79-81.LIU L J,LI X W,LI S H,et al.Determination of iodine content in fresh milk and milk powder by alkali ashing arsenic cerium catalytic spectrophotometry[J].Chinese Journal of Endemic Disease Prevention and Control,2006（2）:79-81.
[18] KIMMO L,MATTI N,PAAVO P.Development of an efficient acid digestion procedure utilizing high-pressure asher technique for the determination of iodine and metallic elements in milk powder[J].Food Analytical Methods,2014,7（5）:1 103-1 108.
[19] 袁辉,严娅.ICP-MS测定婴幼儿乳粉中碘含量不确定度的评定[J].广州化工,2021,49（19）:99-100,106.YUAN H,YAN Y.Evaluation of uncertainty of determination of iodine content in infant milk powder by ICP-MS[J].Guangzhou Chemical Industry,2021,49（19）:99-100,106.
[20] 李姗,何霜,李吉龙,等.KOH快速消解/ICP-MS测定婴幼儿乳粉中总碘含量[J].分析测试学报,2016,35（7）:864-868.LI S,HE S,LI J L,et al.Determination of total iodine in infant formula by KOH digestion and Inductively coupled plasma mass spectrometry[J].Journal of Instrumental Analysis,2016,35（7）:864-868.