Abstract
Objective:This study contributed to overcoming the disadvantages of hydrophobicity of CBD broad-spectrum oil and poor stability caused by oil coalescence.Methods: CBD broad-spectrum oil was dissolved in five kinds of solvents, and two kinds of solvents with better solubility were obtained by the appearance of the solution. The solubility of broad-spectrum oil in two solvents was determined by UV spectrophotometry at 313~363 K, and the solvent with the highest solubility was obtained. In this solvent, the solubility of CBD broad-spectrum oil was determined at 313~353 K to correlate the Apelblat model. The number of oil drops of CBD broad-spectrum oil with different concentrations and tween dispersant with different volume fractions were observed.Results: The two solvents with good solubility were caprylic capric triglyceride (CCT) and 1,2-propanediol. At the same temperature, the solvent with the highest solubility was CCT. Under CBD-CCT, the correlation coefficient (R2) of Apelblat model is more than 0.98, the relative deviation (RD) is less than 2.78%, and the root mean square error (RSMD) is 4.1×10-3. The relationship between molar solubility and temperature is in accordance with Apelblat model. When the mass concentration of CBD-CCT was 170 mg/mL, with and Tween 80 dispersant with 10% volume fraction added, the highest anti coalescence and stability of the system was found.Conclusion: CBD-CCT can be in a stable state and has positive significance in the preparation and storage of CBD food and health products.
Publication Date
7-7-2022
First Page
10
Last Page
15
DOI
10.13652/j.issn.1003-5788.2022.02.002
Recommended Citation
Yong-qiang, MA; Ke-xin, TANG; Xin, WANG; Yu, LUO; and Yu, PENG
(2022)
"Effect of solvent on solubility and anti coalescence stability of CBD broad spectrum oil,"
Food and Machinery: Vol. 38:
Iss.
2, Article 2.
DOI: 10.13652/j.issn.1003-5788.2022.02.002
Available at:
https://www.ifoodmm.cn/journal/vol38/iss2/2
References
[1] 孔剑梅,沈琰.工业大麻花叶提取大麻二酚工艺技术综述[J].云南化工,2019,46(8):1-4.KONG Jian-mei,SHEN Yan.Review on extraction technology of cannabinol from industrial hemp leaves[J].Yunnan Chemical Industry,2019,46(8):1-4.
[2] BURSTEIN S.Cannabidiol(CBD)and its analogs:A review of their effects on inflammation[J].Bioorg Med Chem,2015,23(7):1 377-1 385.
[3] BRIDGEMAN M B,ABAZIA D T.Medicinal cannabis:History,pharmacology,and implications for the acute care setting[J].A Peer-reviewed Journal for Formulary Management,2017,42(3):180-188.
[4] 吴军,于海波.大麻二酚在神经精神疾病中的作用与分子机制研究进展[J].药学学报,2020,55(12):2 800-2 810.WU Jun,YU Hai-bo.Research progress on the role and molecular mechanism of cannabinol in neuropsychiatric diseases[J].Acta Pharma Sinica,2020,55(12):2 800-2 810.
[5] 王语聪,谢智鑫,杨文敏,等.汉麻叶中大麻二酚的分离纯化及其抗抑郁功能[J].精细化工,2021,38(4):795-800,805.WANG Yu-cong,XIE Zhi-xin,YANG Wen-Min,et al.Separation and purification of cannabinoid from hemp leaves and its antidepressant function[J].Fine Chemical Industry,2021,38(4):795-800,805.
[6] 高哲,张志军,李晓君,等.火麻叶中大麻二酚的热回流法提取工艺研究[J].中国油脂,2019,44(3):107-111.GAO Zhe,ZHANG Zhi-jun,LI Xiao-jun,et al.Study on the extraction process of cannabinol from hemp leaves by thermal reflux[J].China Oil,2019,44(3):107-111.
[7] 周莹,陈念念,韩丽,等.UPLC-MS/MS同时测定四种食品基质中痕量四氢大麻酚、大麻二酚和大麻酚[J].现代食品科技,2019,35(12):315-321,301.ZHOU Ying,CHEN Nian-nian,HAN Li,et al.Simultaneous determination of trace tetrahydrocannabinol,cannabidiol and cannabinol in four food matrices by UPLC-MS/MS[J].Modern Food Science and Technology,2019,35(12):315-321,301.
[8] MILLAR S A,MAGUIRE R F,YATES A S,et al.Towards better delivery of cannabidiol(CBD)[J].Pharmaceuticals,2020,13(9):2 020.
[9] NATHAN K,OLIVIER J,YOURI G,et al.Cannabidiol aqueous solubility enhancement:Comparison of three amorphous formulations strategies using different type of polymers[J].International Journal of Pharmaceutics,2020,589:119812.
[10] HELENE P B,MAAIKE C K,MAAIKE J E,et al.Solubility of non-psychoactive cannabinoids in supercritical carbon dioxide and comparison with psychoactive cannabinoids[J].The Journal of Supercritical Fluids,2010,55(2):603-608.
[11] 郭惠,杨若澜,李卫涛,等.紫外分光光度法测定吴茱萸碱及吴茱萸次碱的溶解度及油水分配系数[J].化学与生物工程,2019,36(11):64-67.GUO Hui,YANG Ruo-lan,LI Wei-tao,et al.Determination of solubility and oil-water partition coefficient of evodiamine and rutaecarpine by UV spectrophotometry[J].Chemistry and Bioengineering,2019,36(11):64-67.
[12] LALIT K,SUHAS B S,GIRISH K P,et al.Determination of saturated solubility of naproxen using UV visible spectrophotometer[J].Research Journal of Pharmacy and Technology,2015,8(7):825-828.
[13] 袁飞,何琳,丁沐淦,等.静态法与动态法测定药物水中溶解度的探讨[J].广东药学院学报,2010,26(5):462-465.YUAN Fei,HE Lin,DING Mu-gan,et al.Determination of solubility of drugs in water by static method and dynamic method[J].Journal of Guangdong Pharmaceutical University,2010,26(5):462-465.
[14] 李鹏娟,李颖,汪勇,等.水溶性抗氧化剂迷迭香酸在大豆油中溶解特性研究[J].中国油脂,2020,45(5):36-41.LI Peng-juan,LI Ying,WANG Yong,et al.Study on the solubility of rosmarinic acid in soybean oil[J].Chinese Journal of Oils and Fats,2020,45(5):36-41.
[15] JIE Li,ZHANG Xin-wei,LIU Quan-jie,et al.Measurement and correlation of solubility of 1,3,5-trioxane in binary solvents from(288.15 to 328.15)K[J].Journal of Molecular Liquids,2017,234:469-480.
[16] ZHANG Xiang-yang,QIAN Gang,WANG Rui,et al.Correlation of solubility and calculation of thermodynamic properties of guanidine nitrate in different solvents[J].Fluid Phase Equilibria,2015,388:59-65.
[17] 姚晓雪,姚晓琳,徐凯,等.辛癸酸甘油酯和橄榄油的极性调控研究[J].食品工业科技,2019,40(17):8-12.YAO Xiao-xue,YAO Xiao-lin,XU Kai,et al.Study on polarity regulation of octadecanoic acid glyceride and olive oil[J].Food Industry Science and Technology,2019,40(17):8-12.
[18] 陈丽芳,张勤勤,林田,等.硼酸在氯化钙溶液中溶解度的测定与关联[J].无机盐工业,2019,51(5):70-73.CHEN Li-fang,ZHANG Qin-qin,LIN Tian,et al.Determination and correlation of solubility of boric acid in calcium chloride solution[J].Inorganic Salt Industry,2019,51(5):70-73.
[19] LESLIE Y,OMAR K,MATAR E S,et al.Film drainage between two surfactant-coated drops colliding at constant approach velocity[J].Journal of Colloid and Interface Science,2003,257(1):93-107.
[20] SUBRAMANIE A P,VPADHI A,RIDZUAN N,et al.Experimental study on the effect of wax inhibitor and nanoparticles on rheology of Malaysian crude oil[J].Journal of King Saud University-Engineering Sciences,2020,32(8):479-483.
[21] 刘方,陈强,张冬翔.水包油乳液的流变特性和黏度实验研究[J].工程热物理学报,2020,41(12):2 908-2 913.LIU Fang,CHEN Qiang,ZHANG Dong-xiang.Experimental study on rheological properties and viscosity of oil in water emulsion[J].Journal of Engineering Thermophysics,2020,41(12):2 908-2 913.
[22] 任智,陈志荣,吕德伟.非离子表面活性剂乳液体系抗聚并稳定性的实验与分析[J].化工学报,2002(3):257-262.REN Zhi,CHEN Zhi-rong,LU De-wei.Experiment and analysis of anti aggregation stability of nonionic surfactant emulsion system[J].Acta Chemical Engineering,2002(3):257-262.