Abstract
Objective:In presence of measurement uncertainty evaluation, the detection methods, with water-sodium chloride pretreatment, for health food was evaluated.Methods:A mathematical model was established to analysis of uncertainty sources. Then the individual components of uncertainty were evaluated. Finally, the combined uncertainty and extended uncertainty were calculated.Results:The uncertainty caused by several factors, including the fitting of the standard curve, the preparation of solution and standard, the repeatability of measurement, and the weigh of sample.The contents of mevastatin, lovastatin and simvastatin were 0.099 2, 0.101 0, 0.099 5 mg/kg in health foods, respectively. The relative combined standard uncertainties were about 0.003 2, 0.005 6, 0.005 1 mg/kg,k=2.Conclusion:Water-sodium chloride pretreatmen can reduce the interference of matrix and the uncertainty introduced by repeatability.
Publication Date
9-2-2022
First Page
79
Last Page
84
DOI
10.13652/j.spjx.1003.5788.2022.80024
Recommended Citation
Li-xia, ZHANG; Qing-yuan, GUO; Qi-cheng, HUA; and Xiang-mei, LI
(2022)
"Uncertainty evaluation on determination of statins in health food by Gas Chromatography Mass Spectrometry (GC-MS),"
Food and Machinery: Vol. 38:
Iss.
6, Article 15.
DOI: 10.13652/j.spjx.1003.5788.2022.80024
Available at:
https://www.ifoodmm.cn/journal/vol38/iss6/15
References
[1] 张璐,李克强,朱辉,等.保健食品中非法添加化学药物及检测技术研究进展[J].食品安全质量检测学报,2021,12（3）:904-913.ZHANG Lu,LI Ke-qiang,ZHU Hui,et al.Research progress on illegal additions of chemical drugs in health food for weight loss and their detection technologies[J].Journal of Food Safety and Quality,2021,12（3）:904-913.
[2] 韩智,龚蕾,王会霞,等.UPLC-MS/MS同时测定保健食品中洛伐他汀及其类似物[J].食品与机械,2019,35（3）:58-62.HAN Zhi,GONG Lei,WANG Hui-xia,et al.Simultaneous UPLC-MS/MS analysis of lovastatin and its analogue for fuctional foods[J].Food & Machinery,2019,35（3）:58-62.
[3] 艾中华.我国保健食品生产经营行政监管问题与对策研究[D].石家庄:河北科技大学,2019:6AI Zhong-hua.Study on public policy and administrative supervision for health food production and operation in China[D].Shijiazhuang:Hebei University of Science and Technology,2019:6.
[4] 王小兵,李启艳,冉金凤,等.超高效液相色谱-四极杆/飞行时间高分辨质谱法用于保健食品中6种非法添加降脂类药物的快速筛查与定量分析[J].食品安全质量检测学报,2019,10（5）:1 214-1 219.WANG Xiao-bing,LI Qi-yan,RAN Jin-feng,et al.Rapid screening and quantitative analysis of 6 kinds of lipid-lowering drugs illegally added in health food by ultra performance liquid chromatography tandem quadrupole/time-of-flight high resolution mass spectrometry[J].Journalof Food Safety and Quality,2019,10（5）:1 214-1 219.
[5] 孙亮,张蓉,邬国庆,等.高效液相色谱法同时测定保健食品中9种非法添加降脂类药物[J].食品安全质量检测学报,2016,7（8）:3 098-3 102.SUN Liang,ZHANG Rong,WU Guo-qing,et al.Rapid screening and quantitative analysis of 6 kinds of lipid-lowering drugs illegally added in health food by ultra performance liquid chromatography tandem quadrupole/time-of-flight high resolution mass spectrometry[J].Journal of Food Safety and Quality,2016,7（8）:3 098-3 102.
[6] 曹晓琴,方振峰,张涛,等.TLC-UPLC-MS/MS法检测网红保健品中非法添加的8种化学药物[J].食品科学,2019,40（16）:335-342.CAO Xiao-qin,FANG Zhen-feng,ZHANG Tao,et al.Determination of eight illegal drugs in internet-famous health foods by thin-layer chromatography coupled to ultra performance liquid chromatography-tandem mass spectrometry[J].Food Science,2019,40（16）:335-342.
[7] 张鑫鑫,李霖,郜雅楠,等.离子迁移谱法同时测定减肥类保健品中5种非法添加物的含量[J].理化检验:化学分册,2018,54（12）:1 419-1 424.ZHANG Xin-xin,LI Lin,GAO Ya-nan,et al.Determination of five kinds of illegal additives in weight loss health products by ion mobility spectrometry[J].Physical Testing and Chemical Analysis part B:Chemical Analysis,2018,54（12）:1 419-1 424.
[8] LI Xiang-mei,CHEN Xiao-min,WU Xin-ze,et al.Rapid detection of adulteration of dehydroepiandrosterone in slimming products by competitive indirect enzymelinked immunosorbent assay and lateral flow immunochromatography[J].Food and Agricultural Immunology,2019,30（1）:123-139.
[9] 黄艳萍,袁萍,黄勇红.减肥保健品中西布曲明的近红外光谱法快速测定[J].海峡药学,2015,27（11）:42-44.HUANG Yan-ping,YUAN Ping,HUANG Yong-hong.Analysis of sibutramine in weight-loss healthy food by NIR combined with wavelet transform and artificial neural network[J].Strait Pharmaceutical Journal,2015,27（11）:42-44.
[10] 孙丽萍,李薇.HPLC法测定保健食品中洛伐他丁含量的不确定度分析[J].中国卫生检验杂质,2009,19（9）:2 175-2 176.SUN Li-ping,LI Wei.Uncertainty evaluation for determination of Lovastatin in health foods by high-performance liquid chromatography[J].Chinese Journal of Health Laboratory Technology,2009,19（9）:2 175-2 176.
[11] 徐晓楠,叶刚,张楠,等.液相色谱—串联质谱法测定减肥降脂通便类保健食品中38种非法添加药物[J].食品安全质量检测学报,2020,11（17）:6 075-6 085.XU Xiao-nan,YE Gang,ZHANG Nan,et al.Determination of 38 kinds of illegally added drugs in health food for reducing weight,reducing blood fat and relaxing the bowels by liquid chromatography-tandem mass spectrometry[J].Journal of Food Safety and Quality,2020,11（17）:6 075-6 085.
[12] 中华人民共和国农业部.蔬菜和水果中有机磷、有机氯、拟除虫菊酯和氨基甲酸酯类农药多残留的测定:NY/T 761—2008[S].北京:中国农业出版社,2008.The Ministry of Agriculture.Pesticide multiresidue screen methods for determination of organophorus pesticides,organochlorine pesticides,pyrethroid pesticides and carbamate pesticedes in vegetables and fruits:NY/T 761—2008[S].Beijing:China Agriculture Press,2008.
[13] 刘飞波,王希,刘水平.QuEChERS-HPLC法快速测定黄豆芽中6-苄基腺嘌呤含量的不确定度评定[J].食品与机械,2021,37（11）:67-71.LIU Fei-bo,WANG Xi,LIU Shui-ping.Evaluation of the uncertainty for determination of 6-benzyladenine in soybean sprouts by QuEChERS high-performance liquid chromatography[J].Food & Machinery,2021,37（11）:67-71.
[14] 汪春明,张洋,施鹏斐,等.气相色谱—质谱法测定黄瓜中毒死蜱残留量的测量不确定度[J].食品工业科技,2021,42（15）:204-210.WANG Chun-ming,ZHANG Yang,SHI Peng-fei,et al.Uncertainty evaluation of chlorpyrifos residues in cucumber determination by gas chromatography-tandem mass spectrometry[J].Science and Technology of Food Industry,2021,42（15）:204-210.
[15] 闫顺华,王亚丽,夏依拉·艾尼.液相色谱—质谱/质谱法测定猪肉中4种磺胺类药物残留量的不确定度评定[J].食品与机械,2021,37（7）:69-75.YAN Shun-hua,WANG Ya-li,XIA-YI-LA·Ai-ni.Uncertainty evaluation for the determination of 4 kinds of Sulfonamides residues in pork by LC-MS/MS[J].Food & Machinery,2021,37（7）:69-75.
[16] 王赛楠,邓迎春,高天蓝星,等.液相色谱串联质谱法测定保健食品中西布曲明的不确定度[J].食品与机械,2020,36（4）:91-94.WANG Sai-nan,DENG Ying-chun,GAO Tian-lan-xing,et al.Uncertainty evaluation for determination of sibutramine in health foods by liquid chromatography-tandem mass spectrometry[J].Food & Machinery,2020,36（4）:91-94.