The overview of sn-2 palmitate content in breastmilkand current research status

Authors

DONG Ling, Aus nutria Dairy〔China〕Co., Ltd., Changsha, Hunan 410200 , China ；Aus nutria Instituteof Food and Nutrition, Changsha, Hunan 410200 , China ；Hunan Enginering and TechnologyResearch Center for Nutrition and Health Products, Changsha, Hunan 410200 , China
ZHOU Xin-yue, Aus nutria Dairy〔China〕Co., Ltd., Changsha, Hunan 410200 , China ；Aus nutria Instituteof Food and Nutrition, Changsha, Hunan 410200 , China ；Hunan Enginering and TechnologyResearch Center for Nutrition and Health Products, Changsha, Hunan 410200 , China
JIANG Yi-kang, Aus nutria Dairy〔China〕Co., Ltd., Changsha, Hunan 410200 , China ；Aus nutria Instituteof Food and Nutrition, Changsha, Hunan 410200 , China ；Hunan Enginering and TechnologyResearch Center for Nutrition and Health Products, Changsha, Hunan 410200 , China
LI Wei, Aus nutria Dairy〔China〕Co., Ltd., Changsha, Hunan 410200 , China ；Aus nutria Instituteof Food and Nutrition, Changsha, Hunan 410200 , China ；Hunan Enginering and TechnologyResearch Center for Nutrition and Health Products, Changsha, Hunan 410200 , China
PAN Li-na, Aus nutria Dairy〔China〕Co., Ltd., Changsha, Hunan 410200 , China ；Aus nutria Instituteof Food and Nutrition, Changsha, Hunan 410200 , China ；Hunan Enginering and TechnologyResearch Center for Nutrition and Health Products, Changsha, Hunan 410200 , China

Abstract

Thecomparisonofsn-2palmitatecontentinhumanmilk and animal milk in China， Europe and the United States， aswellastheresearchreports onthe physiological functionofinfants and young children were reviewed.The application andpotential prospect of sn-2 palmitate in infant food were also pros-pected.

Publication Date

10-16-2022

First Page

1

Last Page

6

DOI

10.13652/j.spjx.1003.5788.2022.60074

Recommended Citation

Ling, DONG; Xin-yue, ZHOU; Yi-kang, JIANG; Wei, LI; and Li-na, PAN (2022) "The overview of sn-2 palmitate content in breastmilkand current research status," Food and Machinery: Vol. 38: Iss. 9, Article 1.
DOI: 10.13652/j.spjx.1003.5788.2022.60074
Available at: https://www.ifoodmm.cn/journal/vol38/iss9/1

References

[1] 夏袁,项静英,曹晓辉,等.无锡地区人乳脂肪脂肪酸组成及sn-2位脂肪酸分布[刀].中国油脂,2015,40(11):44-47.XIA Y,XIANG JY,CAO XH,etal.Fatty acid composition and thedistribution insn-2 position of human milkfat in Wuxi area[J].Chi-na Oils and Fats,2015,40(11):44-47.
[2] 陈爱菊,张伟利,蒋明华,等.我国5个地区人乳中脂肪酸成分的分析[J].临床儿科杂志,2014,32(1):48-54.CHEN AJ,ZHANG WL,JIANGMH,etal.Analysis of fatty acidcomposition of human milk in 5 regions of China[J].Journal ofClinical Pediatrics,2014,32(1):48-54.
[3] 刘彪,叶文慧,郭顺堂.母乳及市售婴儿配方奶粉中脂肪酸结构分析[J].中国食品学报,2018,18(10):246-251.LIU B,YEW H,GUO ST.Analysis of fatty acid structure in hu-man milk and commercial infant formula[J].Journal of China FoodScience and Technology,2018,18(10):246-251.
[4] KALLIO H,NYLUND M,BOSTROM P,etal.Triacylglycerol re-gio isomers in human milk resolved with an algorithmic novel elec-tro spray ionization tandem mass spectrometry method[J].FoodChemistry,2017,233:351-360.
[5] GIU F FRIDA F,MARMET C,TAVA ZZ II,etal.Quantification of 1,3-di oleoyl-2-palmitate(OPO)and palmitic acid insn-2 position oftriacylglycerols in human milk by liquid chromatography coupledwith mass spectrometry[].Molecules,2018,24(1):22.
[6] ZOU X,HUANG J,JIN Q,etal.Lipid composition analysis of milkfats from different mammalian species:Potential for use as humanmilkfat substitutes[J].Journal of Agricultural&Food Chemistry,2013,61(29):7070-7080.
[7] 余晓雯,刘茜,刘妍,等.母乳中1-油酰基-2棕榈酰基-3-亚油酰基甘油三酯的研究进展].中国油脂,2022,47(5):16-22,34.YU XW,LIU Q,LIU Y,etal.Research progress of l-oleoyl-2-palmitoyl-3-linoleylglyceridein human milk[].China Oils and Fats,2022,47(5):16-22,34.
[8] 陈盛,陈景春,何亚斌.1,3-二油酸2棕榈酸甘油三酯(OPO)检测技术综述刀.广州化工,2016,44(3):26-27,58.CHEN S,CHEN JC,HEY B.Review of 1,3-di ole oly-2-palmitatetriglyceride(OPO)detection technology[J].Guangzhou ChemicalIndustry,2016,44(3):26-27,58.
[9] 张星河,韦伟,李菊芳,等.母乳1,3-二不饱和脂肪酸-2棕榈酸甘油三酯(UPU)的组成与营养功能[刀].中国油脂,2022,12(1):1-12.ZHANG XH,WE IW,LIJ F,etal.Composition and nutritionalfunction of 1,3-di unsaturated fatty acid-2-palmitate triglyceride(UPU)in human milk[].China Oils and Fats,2022,12(1):1-12.
[10] 张雪,张丽茹,张筠.婴幼儿配方乳粉中1,3-二油酸-2棕榈酸甘油三酯的功能及检测方法研究进展[J].中国乳业,2019(5):57-60.ZHANG X,ZHANG LR,ZHANG J.Research progress on thefunction and analysis method of 1,3-di oleoyl-2-palmitate in infantformula milk powder[].China Dairy Industry,2019(5):57-60.
[11] 何香婷,刘玲君,陈亮,等.婴幼儿配方奶粉中1,3-二油酸-2-棕榈酸甘油三酯的定量测定方法[J].产业与科技论坛,2021,20(4):46-48.HEXT,LIU LJ,CHEN L,etal.Determination of 1,3-di oleoyl-2-palmitate triglycerideininfant formula[J].IndustryandTechnology Forum,2021,20(4):46-48.
[12] 陆雪龙,黄芳芳,王巧云,等.气相色谱法测定婴幼儿乳粉中的1,3-二油酸-2棕榈酸甘油三酯[J].食品安全质量检测学报,2020,11(6):1973-1977.LUX L,HUANG FF,WANG QY,etal.Determination of 1,3-di-oleoyl-2 palmitate triglyceride in infant formula by gas chroma-tography[.Journal of Food Safety and Quality Inspection,2020,11(6):1973-1977
[13] 韦伟,屠海云,王红青,等.Silver ion HPLC测定1,3-二油酸-2-棕榈酸三酰甘油的含量[J].中国粮油学报,2014,29(1):105109,115.WE IW,TU HY,WANG HQ,etal.Determination of l,3-dio-leo yl-2-palmitate triacylglycerol by Silver Ion HP LCD].Journal ofCereals and Oils of China,2014,29(1):105-109,115.
[14] 刘元林,龙鸣,李儒,等.脂肪酸检测在食品工业中的应用研究进展门.食品与机械,2019,35(11):217-222LIU YL,LONG M,LIR,etal.Application of fatty acid analysisin food industry[].Food&Machinery,2019,35(11):217-222
[15] TUA,MAQ,BAI H,etal.A comparative study of triacylglycerolcomposition in Chinese human milk within different lactationstages and imported infant formula by SFC coupled with Q-T OF-MS[].Food Chemistry,2017,221:555-567.
[16] 宋长虹,唐生,郝克非,等.中国居民日常食物中脂肪酸含量的分析刀.食品与机械,2014,30(5):61-63SONGCH,TANGS,HAO KF,etal.Analysis of fatty acid con-tent in daily intake of Chinese residents[刀].Food&Machinery,2014,30(5):61-63.
[17] 陈玉洁,张鑫,张兰威,等.中国市场主流婴幼儿配方奶粉中甘油三酯种类与结构特征[Cy/中国食品科学技术学会第十五届年会论文摘要集.青岛:[出版者不详],2018:615CHEN YJ,ZHANG X,ZHANG LW,etal.Type and structurecharacteristics of triglycerides in mainstream infant formula inChina market[C]//Abstract Collection of the 15h Annual Meetingof Chinese Society of FoodScience and Technology.Qingdao:[s.n.],2018:615.
[18] 杨普煜,张虹,刘浚辰,等.Sn-2棕榈酸酯对婴幼儿健康的促进作用刀.食品科学技术学报,2018,36(4):41-45,68.YANG PY,ZHANG H,LIU JC,etal.Promotion effect of SN-2palmitate on infant health[J].Journal of FoodScience and Tech-nology,2018,36(4):41-45,68
[19] MILES EA,CALDER PC.The influence of the position of pal-mi tate in infant formula triacylglycerols on health outcomes[J]Nutrition Research,2017,44:1-8.
[20] JIANG T,LIU B,LIJ,etal.Association between sn-2fattyacidprofiles of breastmilk and development of the infant intestinal mi-cro biome[J].Food&Function,2018,9(7):1028-1037
[21] WANG J,LIU LH,LIU LB,etal.Absorption of 1,3-di oley l-2-palmitoyl glycerol and intestinal flora profiles changes in mice[JInternational Journal of Food Sciences and Nutrition,2020,71(3):296-306.
[22] CAR NIEL LIV,LUI JEN DIJK I,GO UDO EVERJV,etal.Structural position and amount of palmitic acid in infant formulas:Effects on fat,fatty acid,and mineral balance[].Journal of Pediat-ric Gastroenterology&Nutrition,1996,23(5):553-560
[23] 庄佳璐,贝斐,秦逸诗,等.高sn-2位棕榈酸配方乳对婴儿粪便脂肪酸及钙镁排泄的影响[J].中华临床营养杂志,2018,26(4):214-220.ZHUANG JL,BE IE,QI NYS,etal.Effects of highs n-2 palmitateformula on fecal fatty acid and calcium and magnesium excretionin infants[J].Journal of China Clinical Nutrition,2018,26(4):214-220.
[24] HOUA,XIAOY,LIZ.Effectsofl,3-di oleoyl-2palmitoyl glycerol and its plant-oil formula on the toddler fecal mi-cro biota during invitro fermentation[J].CYT A Journal of Food,2019,17(1):850-863
[25] BRON SKY J,CAMPOY C,EMBLETON N,etal.Palm oil andbeta palmitate in infant formula:A position paper by the Europeansociety for pediatric gastroenterology,hepatology,and nutrition(ESP GHAN)committee on nutrition[].Journal of Pediatric Gas-tro enter ology and Nutrition,2019,68(5):742-760
[26] LAURENT B,XAVIER M,ERIC L,etal.Growth,stoolconsistency and bone mineral content in healthy term infants fedsn-2palmitate-enrichedstarterinfantformula:Arandomized,double-blind,multicentre clinical trial[].Clinical Nutrition,2019,38(3):1023-1030
[27] LITMAN OVITZ I,DAVIDSON K,ELIAKIM A,etal.High beta-palmitate formula andbonestrengthinterm infants:Arandomized,double-blind,controlled trial[J].Calcif Tissue Int,2013,92(1):35-41.
[28] KENNEDY K,FEW TREL LMS,MORLEY R,etal.Double-blind,randomized trial of a synthetic triacylglycerol in formula-fed terminfants:effects on stool biochemistry,stool characteristics,andbone mineralization[J].The American Journal of Clinical Nutrition,1999,70(5):920-927.
[29] SCH AN LERR J,BURNS PA,ABRAMS SA,etal.Bone Mineral-ization outcomes in human milk-fed preterm infants[J].PediatricResearch,1992,31(6):583-586.
[30] FEW TREL LMS,KENN DE YK,MURGATROYD PR,etal.Breast-feeding and formula feeding in healthy term infants andbone health at age 10 years[J].British Journal of Nutrition,2013,110(6):1061-1067.
[31] WANG L,RUIS ECO BG,HAP PER,etal.The effect of calciumpalmitate on bacteria associated with infant gut microbiota[J.Mi-cro biology open,2021,10(3):e 1187.
[32] YARON S,SHACHAR D,ABRAM ASL,etal.Effect of highβpalmitate content in infant formula on the intestinal microbiota ofterm infants[J].J Pediatr Gastroenterol Nutr,2013,56(4):376-381
[33] NOWACKI J,LEE HC,LIEN R,etal.Stool fatty acid soaps,stoolconsistency and gastrointestinal tolerance in term infants fed infantformulas containing highs n-2 palmitate with or without oligo fr uc-tose:Adouble-blind,randomized clinical trial[J].NutritionJournal,2014,13(1):1-11.
[34] 余章斌,韩树萍,朱春,等.配方奶添加棕榈油对婴儿营养吸收和排便影响的Meta分析[J].中华儿科杂志,2009,47(12):904-910Y UZB,HANS P,ZHU C,etal.Effects of palm oil supplement a-tion in formula milk on nutrient absorption and defecation in in-fants:Ametaanalysis[J].JournalofChinaPediatrics,2009,47(12):904-910.
[35] LITMAN OVITZ I,YOSEPH FB,LIFSHITZ Y,etal.Reducedcryinginterminfantsfedhighbetapalmitateformula:Adouble-blind randomized clinical trial[J].Bmc Pediatrics,2014,14(1):1-6.
[36] YOSEPH FB,LIFSHITZ Y,COHEN T,etal.Sn 2-palmitate im-proves crying and sleep in infants fed formula with prebiotics:Adouble blind randomized clinical trial[J].Clinics in Mother&Child Health,2017,14(263):2.
[37] 贝斐.人乳甘油三酯sn-2棕榈酸结构的生理作用[J].国际儿科学杂志,2014,41(1):58-60.BE IF.Physiological role of human milk triglyceride _sn-2palmitate structure[].International Journal of Pediatrics,2014,41(1):58-60.
[38] CAR TAG,MUR RUE,LISA IS,etal.Dietary triacylglycerolswith palmitic acid in the sn-2 position modulate levels of N-acyl e-than olamide sin rat tissues[J].PLoS One,2015,10(3):e 0120424.
[39] JEFFERY NM,SAND RE RS ON P,NEWS HOLME EA,etal.Effects of varying the type of saturated fatty acid in the rat dietupon serum lipid levels and spleen lymphocyte functions[J].Bio-chimica Et Biophysica Acta,1997,1345(3):223-236.
[40] P ENGL,BAR-YOSEPH F,L EVIL,etal.High beta palmitate fatcontrols the intestinal inflammatory response and limits intestinaldamage in mucin muc 2-deficient mice[J].PLoS One,2013,8(6):e65878.
[41] WE IW,JIN Q,WANG X.Humanmilkfatsubstitutes:Pasta-chi eve ments and current trends[J].Progress in Lipid Research2019,74:69-86.
[42] WE IWA,CONG S,WANG XS,etal.Lipase-catalyzed synthesisofsn-2palmitate:Areview[.Engineering,2020,6(4):406414.
[43] CONG S,WE IW,ZOU X,etal.Evaluation of triacylglycerolcomposition in commercial infant formulas on the Chinese market:A comparative study based on fat source and stage[].Food Chem-is try,2018,252:154-162
[44] GAOL,CHENG X,YU X,etal.Lipase-mediated production of 1-oleoyl-2palmitoyl3linoleoyl glycerol by a two step method[J].Food Bioscience,2020,36:100678.
[45] ZHANG N,ZENG JP,W UYP,etal.Human milk sn-2 palmitatetriglyceride rich in linoleic acid had lower digestibility but higherabsorptivity compared with the sn-2 palmitate triglyceride rich inoleic acid invitro[J].Journal of Agricultural and Food Chemistry,2020,69(32):9137-9146.