•  
  •  
 

Abstract

This review summarized the latest research progress on the active components and comprehensive utilization of R. chingii Hu, and points out that the active components and functional characteristics of R. chingii Hu should be further explored, and it should be widely used in the fields of medical care, food and daily chemical products.

Publication Date

10-16-2022

First Page

219

Last Page

226

DOI

10.13652/j.spjx.1003.5788.2022.90216

References

[1] 廖天月,詹志来,徐瑾,等.覆盆子本草考证[J].中国中药杂志,2021,46(10):2 607-2 616.LIAO T Y,ZHAN Z L,XU J,et al.Herbal textual research on Rubi Fructus[J].China Journal of Chinese Materia Medica,2021,46(10):2 607-2 616.
[2] 国家药典委员会.中国药典:一部[S].北京:中国医药科技出版社,2020:399.Chinese Pharmacopoeia Commission.Chinese pharmacopoeia:I[S].Beijing:China Medical Science and Technology Press,2020:399.
[3] LIU M X,NIU J.Advance research on raspberry(Rubus chingii Hu)and resource utilization[J].Sci Techn Vis,2014,22:26-27.
[4] XIE Y H,LIAN B,GONG J H,et al.Preparation of magnetic chitosan hyamine microspheres and separation of phenolic acids from Rubus chingii Hu[J].Advanced Materials Research,2013,634:1 347-1 351.
[5] BABY B,ANTONY P,VIJAYAN R.Antioxidant and anticancer properties of berries[J].Critical Reviews in Food Science and Nutrition,2018,58(15):2 491-2 507.
[6] BASU A,SCHELL J,SCOFIELD R H.Dietary fruits and arthritis[J].Food & Function,2018,9(1):70-77.
[7] BAUZA-KASZEWSKA J,ZARY-SIKORSKA E,GUGOLEK A,et al.Synergistic antimicrobial effect of raspberry(Rubus idaeus L.,Rosaceae)preparations and probiotic bacteria on enteric pathogens[J].Polish Journal of Food and Nutrition Sciences,2021,71(1):132897.
[8] 姜娟萍,徐丹彬,王松琳,等.浙江省覆盆子产销现状及发展对策[J].浙江农业科学,2021,62(1):55-56,60.JIANG J P,XU D B,WANG S L,et al.Production and marketing status and development countermeasures of Rubus Chingii Hu in Zhejiang Province[J].Journal of Zhejiang Agricultural Sciences,2021,62(1):55-56,60.
[9] ZHANG T T,LU C L,JIANG J G,et al.Bioactivities and extraction optimization of crude polysaccharides from the fruits and leaves of Rubus chingii Hu[J].Carbohydrate Polymers,2015,130:307-315.
[10] ZENG H J,ZHE L,WANG Y P,et al.Studies on the anti-aging activity of a glycoprotein isolated from Fupenzi(Rubus chingii Hu.)and its regulation on klotho gene expression in mice kidney[J].International Journal of Biological Macromolecules,2018,119:470-476.
[11] KE H,BAO T,CHEN W.New function of polysaccharide from Rubus chingii Hu:Protective effect against ethyl carbamate induced cytotoxicity[J].Journal of the Science of Food and Agriculture,2021,101(8):3 156-3 164.
[12] DERRICK S A,KRISTO A S,REAVES S K,et al.Effects of dietary red raspberry consumption on pre-diabetes and type 2 diabetes mellitus parameters[J].International Journal of Environmental Research and Public Health,2021,18(17):9 364.
[13] 朱会霞,孙金旭,孙浩.HPLC法分析覆盆子多糖单糖组分的研究[J].山东化工,2019,48(23):108-110.ZHU H X,SUN J X,SUN H.The analyzing monosaccharide composition of polysaccharides for raspberry[J].Shandong Chemical Industry,2019,48(23):108-110.
[14] YU Z,LIU L,XU Y,et al.Characterization and biological activities of a novel polysaccharide isolated from raspberry(Rubus idaeus L.)fruits[J].Carbohydrate Polymers,2015,132:180-186.
[15] YANG Y J,XU H M,SUO Y R.Raspberry pulp polysaccharides inhibit tumor growth via immunopotentiation and enhance docetaxel chemotherapy against malignant melanoma in vivo[J].Food & Function,2015,6(9):3 022-3 034.
[16] BAENAS N,NUEZ-GMEZ V,NAVARRO-GONZLEZ I,et al.Raspberry dietary fibre:Chemical properties,functional evaluation and prebiotic in vitro effect[J].LWT,2020,134:110140.
[17] ZHANG X,AHUJA J K C,BURTON-FREEMAN B M.Characterization of the nutrient profile of processed red raspberries for use in nutrition labeling and promoting healthy food choices[J].Nutrition and Healthy Aging,2019,5(3):225-236.
[18] LI K,ZENG M,LI Q,et al.Identification of polyphenolic composition in the fruits of Rubus chingii Hu and its antioxidant and antiproliferative activity on human bladder cancer T24 cells[J].Journal of Food Measurement and Characterization,2019,13(1):51-60.
[19] ZHANG W,ZHU Y,LIU Q,et al.Identification and quantification of polyphenols in hull,bran and endosperm of common buckwheat(Fagopyrum esculentum)seeds[J].Journal of Functional Foods,2017,38:363-369.
[20] 韩卓,陈晓燕,李延红,等.顶空—气质联用法对覆盆子叶中挥发性成分的分析[J].食品与机械,2013,29(4):11-13.HAN Z,CHEN X Y,LI Y H,et al.Analysis of volatile constituents of raspberry leaf using HS-GC/MS[J].Food & Machinery,2013,29(4):11-13.
[21] XIAO H M,ZU L B,LI S P,et al.Chemical constituents from dried fruits of Rubus chingii[J].Chin J Med Chem,2011,21(3):220-226.
[22] LIANG W Q,XU G J,WENG D,et al.Anti-osteoporotic components of Rubus chingii[J].Chem Nat Compd,2015,51(1):47-49.
[23] DU L F,LI J,YANG L,et al.Chemical constituents from the fruits of Rubus chingii Hu[J].Nat Prod Res Dev,2014,26(12):1 957-1 960.
[24] 刘杰.覆盆子果实化学成分及对肾阳虚小白鼠药理作用的研究[D].沈阳:沈阳药科大学,2005:11-12.LIU J.Chemical constituents of Rubus Chingii Hu.fruits and its effect on mice with deficiency of Kidney-yang[D].Shenyang:Shenyang Pharmaceutical University,2005:11-12.
[25] ZHANG T T,WANG M,YANG L,et al.Flavonoid glycosides from Rubus chingii Hu fruits display anti-inflammatory activity through suppressing MAPKs activation in macrophages[J].J Funct Foods,2015,18:235-243.
[26] GUO Q L,YANG J S,LIU J X.Studies on chemical constituents in fruits of Rubus chingii[J].China J Chin Mater Med,2007,42:1 141-1 143.
[27] HAN N,GU Y H,YE C,et al.Antithrombotic activity of fractions and components obtained from raspberry leaves(Rubus chingii)[J].Food Chem,2012,132(1):181-185.
[28] 何建明,孙楠,吴文丹,等.HPLC测定覆盆子中鞣花酸,黄酮和覆盆子苷-F5的含量[J].中国中药杂志,2013,38(24):4 351-4 356.HE J M,SUN N,WU W D,et al.Determination of ellagic acid,flavonoids and goshonoside-F5 in Rubi Fructus by HPLC[J].China Journal of Chinese Materia Medica,2013,38(24):4 351-4 356.
[29] 郭启雷.掌叶覆盆子及羊耳菊的化学成分研究[D].北京:中国协和医科大学,2005:63.GUO Q L.Studies on the chemical constituents of Rubus Chingii and Inula Cappa[D].Beijing:Peking Union Medical College,2005:63.
[30] 师聪,解春芝,张建萍,等.覆盆子不同极性溶剂提取物的抗氧化活性比较[J].食品科技,2021,46(1):220-224.SHI C,XIE C Z,ZHANG J P,et al.Comparison of antioxidant activity of raspberry extracts with different polar solvents[J].Food Science and Technology,2021,46(1):220-224.
[31] 陈青,王玉珠,梁延群,等.干燥方式对树莓总酚、总黄酮含量及其体外抗氧化活性的影响[J].北方园艺,2019(13):130-134.CHEN Q,WANG Y Z,LIANG Y Q,et al.Effect of different drying methods on total polyphenols,flavonoids content and antioxidant activity of Rubus Corchorifolius L.[J].Northern Horticulture,2019(13):130-134.
[32] 陈青青,李柯,唐晓清,等.华东覆盆子果、茎与叶的酚类成分及抗氧化活性分析[J].食品科学,2020,41(24):209-215.CHEN Q Q,LI K,TANG X Q,et al.Analysis of phenolic composition and antioxidant activities in fruits,stems and leaves of Rubus chingii Hu[J].Food Science,2020,41(24):209-215.
[33] 付彩群,黄道明,郑露盼,等.不同产地、采收期、种植条件对覆盆子有效成分含量的影响研究[J].药品评价,2021,18(12):728-730.FU C Q,HUANG D M,ZHENG L P,et al.Study on the effect of different producing area,harvest time and planting conditions on the content of active components in Rubus chingii Hu[J].Drug Evaluation,2021,18(12):728-730.
[34] 何佳,周越美,赵智慧,等.不同加工方法与贮存时间对覆盆子含量测定指标的影响[J].医药导报,2022,41(5):693-697.HE J,ZHOU Y M,ZHAO Z H,et al.Effects of the same processing method and storage time on the content determination index of Raspberry[J].Herald of Medicine,2022,41(5):693-697.
[35] LI X,SUN J,CHEN Z,et al.Characterization of carotenoids and phenolics during fruit ripening of Chinese raspberry(Rubus chingii Hu)[J].RSC Advances,2021,11(18):10 804-10 813.
[36] POLISCHUK I,KOMISARENKO M,UPYR T,et al.Study of Rubus Idaeus juice ellagitannins and its antimicrobial activity[J].International Journal of Pharmacy and Chemistry,2019,5(6):68-70.
[37] HATTORI M,KUO K P,SHU Y Z,et al.A triterpene from the fruits of Rubus chingii[J].Phytochemistry,1988,27(12):3 975-3 976.
[38] 谭世强,谢敬宇,郭帅,等.三萜类物质的生理活性研究概况[J].中国农学通报,2012,28(36):23-27.TAN S Q,XIE J Y,GUO S,et al.Research advances in physiological activities of triterpenoids[J].Chinese Agricultural Science Bulletin,2012,28(36):23-27.
[39] YU G,LUO Z,WANG W,et al.Rubus chingii Hu:A review of the phytochemistry and pharmacology[J].Frontiers in Pharmacology,2019,10:799.
[40] SHENG J Y,WANG S Q,LIU K H,et al.Rubus chingii Hu:An overview of botany,traditional uses,phytochemistry,and pharmacology[J].Chinese Journal of Natural Medicines,2020,18(6):401-416.
[41] 郭宣宣,邱晓霞,张玲,等.可见分光光度法测定覆盆子中总三萜含量[J].安徽中医药大学学报,2017,36(5):85-87.GUO X X,QIU X X,ZHANG L,et al.Determination of total triterpenoids in Rubi Fructus by visible spectrophotometry[J].Journal of Anhui University of Chinese Medicine,2017,36(5):85-87.
[42] WAN J,WANG X J,GUO N,et al.Highly oxygenated triterpenoids and diterpenoids from Fructus Rubi(Rubus chingii Hu)and their Nf-Kappa B inhibitory effects[J].Molecules,2021,26(7):1 911.
[43] ZHANG T T,LIU Y J,YANG L,et al.Extraction of antioxidant and antiproliferative ingredients from fruits of Rubus chingii Hu by active tracking guidance[J].Medchemcomm,2017,8(8):1 673-1 680.
[44] ZHONG R,GUO Q,ZHOU G,et al.Three new labdane-type diterpene glycosides from fruits of Rubus Chingii and their cytotoxic activities against five humor cell lines[J].Fitoterapia,2015,102:23-26.
[45] 程科军.Ⅰ.覆盆子活性成分研究 Ⅱ.金雀根中二苯乙烯类成分的稳定性研究[D].上海:复旦大学,2008:31-40.CHENG K J.Ⅰ.Studies on the bioactive constituents of Rubus chingii Ⅱ.Studies on the stability of stilbennoids from the roots of caragana sinica[D].Shanghai:Fudan University,2018:31-40.
[46] 曹煌,张静雅,龚苏晓,等.中药酸味的药性表达及在临证配伍中的应用[J].中草药,2015,46(24):3 617-3 622.CAO H,ZHANG J Y,GONG S X,et al.Expression of sour-taste properties of Chinese materia medica and their applications in clinical compatibility[J].Chinese Traditional and Herbal Drugs,2015,46(24):3 617-3 622.
[47] 曹富,况作品,谢晓梅,等.5种有“味酸”药性的蔷薇科果实类药材中水溶性有机酸的测定与分析[J].北京中医药大学学报,2017,40(7):578-584.CAO F,KUANG Z P,XIE X M,et al.Water-soluble organic acids in 5 fruit medicinal with sour taste from rosaceae family[J].Journal of Beijing University of Traditional Chinese Medicine,2017,40(7):578-584.
[48] 孙金旭,朱会霞,肖冬光.覆盆子中有机酸含量的测定[J].现代食品科技,2013,29(6):1 374-1 376,1 320.SUN J X,ZHU H X,XIAO D G.Determination of the contents of organic acids of raspberry[J].Modern Food Science and Technology,2013,29(6):1 374-1 376,1 320.
[49] 陈晓燕,孙汉巨,程小群,等.覆盆子的氨基酸组成及营养评价[J].合肥工业大学学报(自然科学版),2012,35(12):1 669-1 672.CHEN X Y,SUN H J,CHENG X Q,et al.Study of composition of amino acids in raspberry and nutritive evaluation[J].Journal of Hefei University of Technology(Natural Science),2012,35(12):1 669-1 672.
[50] 伍淑文,樊柏林,刘晓燕,等.湖北掌叶覆盆子叶营养和植物化学物成分分析[J].公共卫生与预防医学,2012,23(2):108-109.WU S W,FAN B L,LIU X Y,et al.Analysis of nutrient and phytochemical components in leaves of Rubus Chingii Hu from Hubei province[J].Journal of Public Health and Preventive Medicine,2012,23(2):108-109.
[51] BILAWAL A,ISHFAQ M,GANTUMUR M A,et al.A review of the bioactive ingredients of berries and their applications in curing diseases[J].Food Bioscience,2021,44:101407.
[52] HENDAWY O,GOMAA H A M,HUSSEIN S,et al.Cold-pressed raspberry seeds oil ameliorates high-fat diet triggered non-alcoholic fatty liver disease[J].Saudi Pharmaceutical Journal,2021,29(11):1 303-1 313.
[53] WU T H,WANG P W,LIN T Y,et al.Antioxidant properties of red raspberry extract alleviate hepatic fibrosis via inducing apoptosis and trans differentiation of activated hepatic stellate cells[J].Biomedicine & Pharmacotherapy,2021,144:112284.
[54] JIANG M J,LI L,HUANG W F,et al.Rubus Chingii var.suavissimus alleviates high-fat diet-induced lipid metabolism disorder via modulation of the PPARs/SREBP pathway in Syrian golden hamsters[J].Journal of Natural Medicines,2021,75(4):884-892.
[55] 樊柏林,龚晨睿,孙凡中,等.湖北掌叶覆盆子叶降血脂作用的动物实验和人群研究[J].食品科学,2007(11):526-529.FAN B L,GONG C R,SUN F Z,et al.Effects of hubei Rubus Chingii Hu leaf on serum lipid metabolism in hyperlipidemia rats and human adults[J].Food Science,2007(11):526-529.
[56] JIANG H,YANG J,FAN Y,et al.Synergistic effects of unripe raspberry extracts(Rubus chingii)and antibiotics against three bacteria[J].Food Science and Technology,2020,41:482-488.
[57] XIAN Y,FAN R,SHAO J,et al.Polyphenolic fractions isolated from red raspberry whole fruit,pulp,and seed differentially alter the gut microbiota of mice with diet-induced obesity[J].Journal of Functional Foods,2021,76:104288.
[58] PAP N,FIDELIS M,AZEVEDO L,et al.Berry polyphenols and human health:Evidence of antioxidant,anti-inflammatory,microbiota modulation,and cell-protecting effects[J].Current Opinion in Food Science,2021,42:167-186.
[59] SCHULZ M,CHIM J F.Nutritional and bioactive value of Rubus berries[J].Food Bioscience,2019,31:100438.
[60] 吴臻,何富乐.覆盆子黄精颗粒保健食品组方配比和功效评价研究[J].健康研究,2021,41(2):160-163,167.WU Z,HE F L.Formulation and efficacy evaluation of Rubi Fructus-Polygonatum granule health food[J].Health Research,2021,41(2):160-163,167.
[61] KE H,BAO T,CHEN W.Polysaccharide from Rubus chingii Hu affords protection against palmitic acid-induced lipotoxicity in human hepatocytes[J].International Journal of Biological Macromolecules,2019,133:1 063-1 071.
[62] SU X,ZHAO M,FU X,et al.Immunomodulatory activity of purified polysaccharides from Rubus chingii Hu fruits in lymphocytes and its molecular mechanisms[J].Journal of Functional Foods,2021,87:104785.
[63] HAN B,CHEN J,YU Y,et al.Antifungal activity of Rubus Chingii extract combined with fluconazole against fluconazole-resistant Candida albicans[J].Microbiology and Immunology,2016,60(2):82-92.
[64] 邢宇双,王烨兴,孟娜娜,等.覆盆子对尼古丁戒断大鼠羟自由基代谢的影响[J].世界最新医学信息文摘,2019,19(86):174-176.XIANG Y S,WANG Y X,MENG N N,et al.Effect of raspberry on hydroxyl radical metabolism in rats with nicotine withdrawal[J].World Latest Medicine Information,2019,19(86):174-176.
[65] 邢宇双,梁启超,金贲临,等.覆盆子对尼古丁戒断焦虑征大鼠的影响[J].实验动物科学,2018,35(5):67-70.XIANG Y S,LIANG Q C,JIN B L,et al.Effect of raspberry extract on anxiety of nicotine with drawal in rats[J].Laboratory Animal Science,2018,35(5):67-70.
[66] 季宇彬,包晓威,单宇,等.覆盆子提取物对ConA致小鼠急性肝损伤的保护作用研究[J].中国中药杂志,2019,44(4):774-780.JI Y B,BAO X W,SHAN Y,et al.Protective effect of raspberry extract on ConA-induced acute liver injuryin mice[J].China Journal of Chinese Materia Medica,2019,44(4):774-780.
[67] 邹佳美.基于分子印迹及分子对接技术的覆盆子中抗阿尔兹海默症的酚酸类活性成分研究[D].南昌:江西中医药大学,2021:12-14.ZOU J M.Study on anti-Alzheimer’s diease phenolic acids in raspberry based on molecular imprinting and technology and molecular docking[D].Nanchang:Jiangxi University of Traditional Chinese Medicine,2021:12-14.
[68] JIANG H,ZHANG W,LI X,et al.The anti-obesogenic effects of dietary berry fruits:A review[J].Food Research International,2021,147:110539.
[69] 广西南宁栩兮科技有限公司.一种功能性粗纤维养生饼干及其制作方法:201610551169.5[P].2016-09-07.Guangxi Nanning Xuxi Technology Co.,Ltd.A kind of functional crude fiber health biscuit and preparation method thereof:201610551169.5[P].2016-09-07.
[70] 韩卓,刘丽姿,娄秋艳,等.覆盆子叶发酵茶的开发[J].北方园艺,2014(4):116-119.HAN Z,LIU L Z,LOU Q Y,et al.Development of raspberry leaf fermented tea[J].Northern Horticulture,2014(4):116-119.
[71] 四川珍福堂商贸有限公司.一种补肾覆盆子叶茶的制作方法:201510399570.7[P].2016-02-03.Sichuan Zhenfutang Trading Co.,Ltd.A kind of preparation method of kidney-tonifying raspberry leaf tea:201510399570.7[P].2016-02-03.
[72] 徐冰,张聪恪,王海玉,等.覆盆子提取物祛黄褐斑作用研究[J].中国实用医药,2012,7(8):24-25.XU B,ZHANG C K,WANG H Y,et al.Study on the effect of removing chloasma of Raspberry extract[J].China Practical Medical,2012,7(8):24-25.
[73] 李安良,杨淑琴,郭秀茹.化妆品活性成分覆盆子酮葡糖苷的研究进展[J].香料香精化妆品,2014(4):63-66.LI A L,YANG S Q,GUO X R.Research and development on cosmetic actives derived from raspberry ketone glucoside[J].Flavour Fragrance Cosmetics,2014(4):63-66.
[74] 宋瑞娜.一种天然抑菌面膜基布及其制备方法和面膜:202011075637.9[P].2021-01-08.SONG R N.A kind of natural antibacterial mask base cloth and its preparation method and mask:202011075637.9[P].2021-01-08.
[75] 庄以彬,吴凤礼,殷华,等.芳香族香料化合物生物合成研究进展[J].生物工程学报,2021,37(6):1 998-2 009.ZHUANG Y B,WU F L,YAN H,et al.Advances in the microbial synthesis of aromatic fragrance molecules[J].Chinese Journal of Biotechnology,2021,37(6):1 998-2 009.
[76] 王萍,王娜,杨俊鹏,等.发酵覆盆子香料的挥发性成分分析[C]//第八届中国香料香精学术研讨会论文集.广州:[出版社不详],2010:79-82.WANG P,WANG N,YANG J P,et al.Analysis of volatile composition in the perfume of Rubus Chingii Hu produced by fermentation[C]//Proceedings of the 8th Seminar on Fragrance and Flavor China.Guangzhou:[s.n.],2010:79-82.
[77] 邓宝安,赵龙,王瑶,等.一种覆盆子提取液对卷烟烟气的影响[J].云南农业科技,2021(4):14-17.DENG B A,ZHAO L,WANG Y,et al.Effect of a raspberry extract on cigarette smoke[J].Yunnan Agricultural Science and Technology,2021(4):14-17.
[78] GUO H,CHANG S,JIA L,et al.Advances in the synthesis and applications of raspberry ketone:A review[J].Flavour and Fragrance Journal,2021,36(6):615-625.
[79] 西安若翰生物饲料有限公司.含大枣及多种药食同源中药的动物发酵饲料及生产装置:202011255135.4[P].2021-01-15.Xi'an Ruohan Biological Feed Co.,Ltd.Animal fermented feed containing jujube and a variety of medicinal and edible Chinese medicines and production equipment:202011255135.4[P].2021-01-15.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.