Abstract
Objective: To investigate the protective effect and mechanism of Lyophyllum ulmarium fibrinolytic enzyme （LUFE） on rats with hyperlipidemia. Methods: Hyperlipidemia models were established by feeding with a high-fat diet, and the model rats were gavaged with different doses of LUFE. HE stain was used to analyze the morphological changes of liver.The biochemical indexes of rat plasma were detected by colorimetric method.WB analyses the expression level of related proteins. Results: LUFE could alleviate the liver tissue injury of hyperlipidemia rats and reduce the plasma lipid level and IL-6, TNF-α，MCP-1，ALT，AST. LUFE can down regulate TLR4，MyD88，phosphorylated PI3K，phosphorylated Akt and phosphorylated NF-кB protein level. Conclusion: LUFE protects against hyperlipidemia-induced liver injury in rats by regulating PI3K/Akt/NF-кB and TLR4/MyD88/NF-кB signaling pathways.
Publication Date
6-5-2023
First Page
156
Last Page
162
DOI
10.13652/j.spjx.1003.5788.2022.80658
Recommended Citation
Yu, LI; Xin, SU; Jun-hui, ZHANG; Rui-meng, ZHANG; and Ming-hua, SHEN
(2023)
"Protective effect of Lyophyllum ulmarium fibrolytic enzyme on liver injury induced in hyperlipidemia rats,"
Food and Machinery: Vol. 39:
Iss.
4, Article 26.
DOI: 10.13652/j.spjx.1003.5788.2022.80658
Available at:
https://www.ifoodmm.cn/journal/vol39/iss4/26
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