Preparation of losartan loaded starch nanoparticles by high-speed shear-inverse miniemulsion method

Authors

DUAN Chao, School of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi 545006, China;Guangxi Key Laboratory of Green Processing of Sugar Resources, Liuzhou, Guangxi 545006, China;Province and Ministry Co-sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Nanning, Guangxi 530004, China
ZHANG Kun-ming, School of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi 545006, China;Guangxi Key Laboratory of Green Processing of Sugar Resources, Liuzhou, Guangxi 545006, China;Province and Ministry Co-sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Nanning, Guangxi 530004, ChinaFollow
HUANG Yong-chun, School of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi 545006, China;Guangxi Key Laboratory of Green Processing of Sugar Resources, Liuzhou, Guangxi 545006, China;Province and Ministry Co-sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Nanning, Guangxi 530004, China
ZHENG Jian-bin, School of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi 545006, China;Guangxi Key Laboratory of Green Processing of Sugar Resources, Liuzhou, Guangxi 545006, China;Province and Ministry Co-sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Nanning, Guangxi 530004, China
TANG Xiang-yi, School of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi 545006, China;Guangxi Key Laboratory of Green Processing of Sugar Resources, Liuzhou, Guangxi 545006, China;Province and Ministry Co-sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Nanning, Guangxi 530004, China

Corresponding Author(s)

张昆明（1985—），男，广西科技大学副教授，博士。E-mail：zhangkm@tju.edu.cn

Abstract

Objective: This study aimed to explore the feasibility of preparation of loaded losartan starch nanoparticles by high-speed shear-reverse microemulsion crosslinking. Methods: Using losartan as model drug and sodium trimetaphosphate as crosslinking agent, the effects of starch solution concentration, sodium trimetaphosphate addition amount, crosslinking time and shear rate on particle size and yield of starch nanoparticles were investigated. Optical micrography, infrared spectrometer and X-ray diffraction were used to characterize losartan loaded starch nanoparticles. Results: The optimal preparation process of nanoparticles was 15% starch solution concentration, 25% sodium trimetaphosphate, 3 h crosslinking time, 5 000 r/min shear rate. Under the control of these conditions, the minimum size of nanoparticles was 755.2 nm, and the yield reached 69.5%. Optical micrography showed that the nanoparticles were round, full and spherical. FTIR showed that losartan was successfully loaded into starch nanoparticles. XRD showed that the nanoparticles exist in amorphous structure. Conclusion: Small particle size drug-carrying starch nanoparticles can be prepared by high-speed shear coupled reversed-phase fine emulsion crosslinking method.

Publication Date

10-20-2023

First Page

6

Last Page

11,18

DOI

10.13652/j.spjx.1003.5788.2022.80715

Recommended Citation

Chao, DUAN; Kun-ming, ZHANG; Yong-chun, HUANG; Jian-bin, ZHENG; and Xiang-yi, TANG (2023) "Preparation of losartan loaded starch nanoparticles by high-speed shear-inverse miniemulsion method," Food and Machinery: Vol. 39: Iss. 6, Article 2.
DOI: 10.13652/j.spjx.1003.5788.2022.80715
Available at: https://www.ifoodmm.cn/journal/vol39/iss6/2

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