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Corresponding Author(s)

孙二娜(1989—),女,蒙牛高科乳制品(北京)有限责任公司高级工程师,博士。E-mail: sunerna@mengniu.cn闻燕(1978—),女,天津商业大学副教授,博士。E-mail:wenyan@tjcu.edu.cn

Abstract

Probiotic fermented milk is an important carrier of probiotics. It enhances the nutritional and health properties of fermented milk by improving the balance of host intestinal microflora and promoting the metabolism of beneficial ingredients. This review expounds the auxiliary effects of probiotics fermented milk in improving intestinal function, regulating body immunity, assisting in treating metabolic diseases and improving mental system diseases, etc., in order to provide theoretical support for expanding the application of probiotics fermented milk.

Publication Date

10-20-2023

First Page

210

Last Page

218,226

DOI

10.13652/j.spjx.1003.5788.2023.80013

References

[1] 刘绒梅, 高达, 孙金威, 等. 传统乳制品中乳酸菌的筛选及发酵性能研究[J]. 中国酿造, 2022, 41(5): 78-83. LIU R M, GAO D, SUN J W, et al. Screening and fermentation performance of lactic acid bacteria in traditional dairy products[J]. China Brewing, 2022, 41(5): 78-83.
[2] 丹彤, 田佳乐, 乔少婷. 具有良好风味德氏乳杆菌保加利亚亚种的筛选及其产香性能分析[J]. 食品与发酵工业, 2021, 47(14): 229-234. DAN T, TIAN J L, QIAO S T. Screening of Lactobacallus delbrueckii subsp. bulgaricus with good flavor properties and analysis of its aroma production[J]. Food and Fermentation Industries, 2021, 47(14): 229-234.
[3] JGER R, MOHR A E, CARPENTER K C, et al. International society of sports nutrition position stand: Probiotics[J]. Journal of the International Society of Sports Nutrition, 2019, 16(1): 62.
[4] 许爱清, 李宗军, 王远亮, 等. 肠道健康导向的功能食品研究进展[J]. 食品与机械, 2010, 26(5): 158-163. XU A Q, LI Z Y, WANG Y L, et al. Progress in the researches on gut-health-oriented functional foods[J]. Food & Machinery, 2010, 26(5): 158-163.
[5] 崔巍, 刘硕, 朱迪凡, 等. 不同人群对肠胃健康食品需求及态度的调查研究[J]. 食品与机械, 2022, 38(12): 156-161. CUI W, LIU S, ZHU D F, et al. Investigation and research on the demand and attitude of different peple to gastrointestinal healthy food[J]. Food & Machinery, 2022, 38(12): 156-161.
[6] 李帅, 袁亚宏, 岳田利. 益生菌发酵藜麦制备ACE抑制肽[J]. 食品与机械, 2022, 38(8): 14-21. LI S, YUAN Y H, YUE T L. Study on the preparation of ACE inhibitory peptidesby probiotic fermentation of quinoa[J]. Food & Machinery, 2022, 38(8): 14-21.
[7] 王慕华, 麻杰, 曹睿, 等. 益生菌的筛选及其发酵特性研究[J]. 中国酿造, 2021, 40(11): 116-121. WANG M H, MA J, CAO R, et al. Screening and fermentation characteristics of probiotics[J]. China Brewing, 2021, 40(11): 116-121.
[8] 罗粤鹏, 杨远帆, 于洋君, 等. 乳酸菌发酵茶花粉对α-葡萄糖苷酶抑制率的影响[J]. 食品与机械, 2022, 38(9): 29-33, 39. LUO Y P, YANG Y F, YU Y J, et al. Effects of lactic acid bacteriafermentated pollens on the inhibition of α-glucosidase[J]. Food & Machinery, 2022, 38(9): 29-33, 39.
[9] 刘敏, 曹志军, 苏杰, 等. 内蒙古传统发酵乳制品中益生酵母菌的筛选及其对Cheddar干酪质构的影响[J]. 中国乳品工业, 2021, 49(7): 18-20, 24. LIU M, CAO Z J, SU J, et al. Screening of probiotics from traditional fermented dairy products in Inner Mongolia and its effect on texture of cheddar cheese[J]. Dairy Industry, 2021, 49(7): 18-20, 24.
[10] 陈荣豪, 陈文学, 陈海明, 等. 番木瓜植物乳杆菌发酵饮料的研制[J]. 食品工业, 2017, 38(9): 62-65. CHEN R H, CHEN W X, CHEN H M, et al. Development and stability of papaya beverage fermented with Lactobacillus plahtarum[J]. The Food Industry, 2017, 38(9): 62-65.
[11] 黄宝莹, 佘之蕴, 沈宏林, 等. 发酵乳中乳酸菌数测定的不确定度评估[J]. 中国乳品工业, 2018, 46(11): 41-44. HUANG B Y, SHE Z Y, SHEN H L, et al. Assessment on uncertainty of Lactic acid bacteria count in fermented milk[J]. Dairy Industry, 2018, 46(11): 41-44.
[12] WANG J, BAI X, PENG C, et al. Fermented milk containing Lactobacillus casei Zhang and Bifidobacterium animalis ssp. lactis V9 alleviated constipation symptoms through regulation of intestinal microbiota, inflammation, and metabolic pathways[J]. Journal of Dairy Science, 2020, 103(12): 11 025-11 038.
[13] RIGO-ADROVER M M, KNIPPING K, GARSSEN J, et al. Prevention of rotavirus diarrhea in suckling rats by a specific fermented milk concentrate with prebiotic mixture[J]. Nutrients, 2019, 11(1): 189.
[14] SIGALA-ROBLES R, SANTIAGO-LPEZ L, HERNNDEZ-MENDOZA A, et al. Peptides, exopolysaccharides, and short-chain fatty acids from fermented milk and perspectives on inflammatory bowel diseases[J]. Digestive Diseases and Sciences, 2022, 67(10): 4 654-4 665.
[15] 孙二娜, 张小妹, 赵伊凡, 等. 副干酪乳杆菌LC-37乳酸菌饮料对人体的促消化和调节肠道菌群作用[J]. 中国食品学报, 2021, 21(10): 95-100. SUN E N, ZHANG X M, ZHAO Y F, et al. The effect of Lactobacillus paracei LC-37 Lactobacillus drink on promoting digestion and regulating intestinal flora[J]. Journal of Chinese Institute of Food Science and Technology, 2021, 21(10): 95-100.
[16] KUMAR S, KHAN R T Y, ISMAIL H, et al. Melanosis coli: A rare entity in elderly patients presenting with constipation[J]. Journal of Advances in Medicine and Medical Research, 2022, 34(7): 66-68.
[17] 李鑫萍. 乳酸菌对泻剂结肠的缓解作用探究[D]. 无锡: 江南大学, 2021: 10-12. LI X P. The study of alleviation effects on cathartic colon by lactic acid bacteria[D]. Wuxi: Jiangnan University, 2021: 10-12.
[18] 白晓晔. 干酪乳杆菌Zhang和动物双歧杆菌乳亚种V9发酵乳缓解便秘机制研究[D]. 呼和浩特: 内蒙古农业大学, 2020: 16-22. BAI X Y. The potential mechanism to alleviate constipation with fermented milk containing Lactolaacilluscasei Zhang and Bifidobacterium animalis subsp. lactic V9[D]. Hohhot: Inner Mongolia Agricultural University, 2020: 16-22.
[19] 汪家琦, 康文丽, 吴忠坤, 等. 益生菌复合配方对小鼠肠道功能的影响[J]. 食品与机械, 2022, 38(8): 7-13. WANG J Q, KANG W L, WU Z K, et al. Effects of composite probiotics on the intestinal function in mice[J]. Food & Machinery, 2022, 38(8): 7-13.
[20] SAKAI T, MAKINO H, ISHIKAWA E, et al. Fermented milk containing Lactobacillus casei strain Shirota reduces incidence of hard or lumpy stools in healthy population[J]. International Journal of Food Sciences and Nutrition, 2011, 62(4): 423-430.
[21] FUKUSHIMA Y, YAMANO T, KUSANO A, et al. Effect of fermented milk containing Lactobacillus johnsonii La1 (LC1) on defecation in healthy japanese adults: A double blind placebo controlled study[J]. Bioscience and Microflora, 2004, 23(4): 139-147.
[22] WANG R, SUN J, LI G, et al. Effect of Bifidobacterium animalis subsp. lactis MN-Gup on constipation and the composition of gut microbiota[J]. Beneficial Microbes, 2021, 12(1): 31-42.
[23] 曹永强, 张健, 郑喆, 等. 副干酪乳杆菌N1115发酵乳对小鼠便秘的改善作用[J]. 食品科学, 2018, 39(1): 185-191. CAO Y Q, ZHANG J, ZHENG Z, et al. Therapeutic effect of Lactobacillus paracasei N1115 fermented milk in constipated mice[J]. Food Science, 2018, 39(1): 185-191.
[24] GUERIN-DANAN C, MESLIN J C, CHAMBARD A, et al. Food supplementation with milk fermented by Lactobacillus casei DN-114 001 protects suckling rats from rotavirus-associated diarrhea[J]. The Journal of Nutrition, 2001, 131(1): 111-117.
[25] BEAUSOLEIL M, FORTIER N, GUNETTE S, et al. Effect of a fermented milk combining Lactobacillus acidophilus Cl1285 and Lactobacillus casei in the prevention of antibiotic-associated diarrhea: A randomized, double-blind, placebo-controlled trial[J]. Canadian Journal of Gastroenterology, 2007, 21(11): 732-736.
[26] RIGO-ADROVER M, SALDAA-RUZ S, VAN LIMPT K, et al. A combination of scGOS/lcFOS with Bifidobacterium breve M-16V protects suckling rats from rotavirus gastroenteritis[J]. European Journal of Nutrition, 2017, 56: 1 657-1 670.
[27] RIGO-ADROVER M M, KNIPPING K, GARSSEN J, et al. Prevention of rotavirus diarrhea in suckling rats by a specific fermented milk concentrate with prebiotic mixture[J]. Nutrients, 2019, 11(1): 189.
[28] MATIJAIC B B, OBERMAJER T, LIPOGLAVEK L, et al. Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of adults with irritable bowel syndrome: A randomized double-blind, placebo-controlled trial[J]. Journal of Dairy Science, 2016, 99(7): 5 008-5 021.
[29] HUNGIN A P S, MITCHELL C R, WHORWELL P, et al. Systematic review: Probiotics in the management of lower gastrointestinal symptoms: An updated evidence-based international consensus[J]. Alimentary Pharmacology & Therapeutics, 2018, 47(8): 1 054-1 070.
[30] ZENG J, LI Y Q, ZUO X L, et al. Clinical trial: Effect of active lactic acid bacteria on mucosal barrier function in patients with diarrhoea-predominant irritable bowel syndrome[J]. Alimentary Pharmacology & Therapeutics, 2008, 28(8): 994-1 002.
[31] MID A, STRNIA L, BAJC K, et al. Randomized clinical trial: The effect of fermented milk with the probiotic cultures Lactobacillus acidophilus La-5 and Bifidobacterium BB-12 and Beneo dietary fibres on health-related quality of life and the symptoms of irritable bowel syndrome in adults[J]. Journal of Functional Foods, 2016, 24: 549-557.
[32] BASHA O M, HAFEZ R A, SALEM S M, et al. Impact of gut microbiome alteration in ulcerative colitis patients on disease severity and outcome[J]. Clinical and Experimental Medicine, 2022, 7: 1-10.
[33] 林鹏程, 曹峻菡, 解万翠. 膳食多酚改善炎症性肠病的作用机制研究进展[J]. 食品与机械, 2021, 37(9): 205-210. LIN P C, CAO J H, XIE W C. Research progress on the mechanism of dietary polyphenols in improving inflammatory bowel disease[J]. Food & Machinery, 2021, 37(9): 205-210.
[34] LEE K Y, TSAI Y C, WANG S Y, et al. Coculture strategy for developing Lactobacillus paracasei PS23 fermented milk with anti-colitis effect[J]. Foods, 2021, 10(10): 2 337.
[35] SANTIAGO-LPEZ L, HERNNDEZ-MENDOZA A, GARCIA H S, et al. The effects of consuming probiotic-fermented milk on the immune system: A review of scientific evidence[J]. International Journal of Dairy Technology, 2015, 68(2): 153-165.
[36] PLOTNIKOVA M A, KLOTCHENKO S A, LEBEDEV K I, et al. Antibody microarray immunoassay for screening and differential diagnosis of upper respiratory tract viral pathogens[J]. Journal of Immunological Methods, 2020, 478: 112712.
[37] WANG Y H, LIMAYE A, LIU J R, et al. Potential probiotics for regulation of the gut-lung axis to prevent or alleviate influenza in vulnerable populations[J]. Journal of Traditional and Complementary Medicine, 2022, 13: 161-169.
[38] ZHANG H, MIAO J, SU M, et al. Effect of fermented milk on upper respiratory tract infection in adults who lived in the haze area of Northern China: A randomized clinical trial[J]. Pharmaceutical Biology, 2021, 59(1): 645-650.
[39] SHIDA K, SATO T, IIZUKA R, et al. Daily intake of fermented milk with Lactobacillus casei strain Shirota reduces the incidence and duration of upper respiratory tract infections in healthy middle-aged office workers[J]. European Journal of Nutrition, 2017, 56: 45-53.
[40] ODINTSOVA V, KLIMENKO N, TYAKHT A, et al. Yogurt fortified with vitamins and probiotics impacts the frequency of upper respiratory tract infections but not gut microbiome: A multicenter double-blind placebo controlled randomized study[J]. Journal of Functional Foods, 2021, 83: 104572.
[41] TRACHOOTHAM D, CHUPEERACH C, TUNTIPOPIPAT S, et al. Drinking fermented milk containing Lactobacillus paracasei 431 (IMULUSTM) improves immune response against H1N1 and cross-reactive H3N2 viruses after influenza vaccination: A pilot randomized triple-blinded placebo controlled trial[J]. Journal of Functional Foods, 2017, 33: 1-10.
[42] 刘夏, 侯彬彬. 益生菌治疗过敏性疾病机制及应用的研究进展[J]. 实用医学杂志, 2022, 38(11): 1 434-1 438. LIU X, HOU B B. Progress on the mechanism and application of probiotic therapy for allergic diseases[J]. The Journal of Practical Medicine, 2022, 34(11): 1 434-1 438.
[43] HAYASHI A, KIMURA M, NAKAMURA Y, et al. Anti-atopic dermatitis effects and the mechanism of lactic acid bacteria isolated from Mongolian fermented milk[J]. Journal of Dairy Research, 2009, 76(2): 158-164.
[44] WATANABE T, HAMADA K, TATEGAKI A, et al. Oral administration of lactic acid bacteria isolated from traditional South Asian fermented milk 'dahi' inhibits the development of atopic dermatitis in NC/Nga mice[J]. Journal of Nutritional Science and Vitaminology, 2009, 55(3): 271-278.
[45] YAMASHITA M, MIYOSHI M, IWAI M, et al. Lactobacillus helveticus SBT2171 alleviates perennial allergic rhinitis in Japanese adults by suppressing eosinophils: A randomized, double-blind, placebo-controlled study[J]. Nutrients, 2020, 12(12): 3 620.
[46] VELEZ E M, MALDONADO GALDEANO C, CARMUEGA E, et al. Probiotic fermented milk consumption modulates the allergic process induced by ovoalbumin in mice[J]. British Journal of Nutrition, 2015, 114(4): 566-576.
[47] 吴炜倩, 陆合, 郭亚楠, 等. 益生菌防治过敏性疾病的进展和展望[J]. 中国微生态学杂志, 2020, 32(7): 862-865, 869. WU W Q, LU H, GUO Y N, et al. Progress and prospect on probiotics in the prevention and treatment of allergic diseases[J]. Chinese Journal of Microecology, 2020, 32(7): 862-865, 869.
[48] 陆婧婧, 王娜娜, 焦文姝, 等. 益生菌缓解肥胖形成相关机制及研究进展[J]. 食品工业科技, 2019, 40(3): 296-299, 306. LU J J, WANG N N, JIAO W S, et al. The mechanism and research progress of probiotics in relieving obesity[J]. Science and Technology of Food Industry, 2019, 40(3): 296-299, 306.
[49] DA SILVA PONTES K S, GUEDES M R, DA CUNHA M R, et al. Effects of probiotics on body adiposity and cardiovascular risk markers in individuals with overweight and obesity: A systematic review and meta-analysis of randomized controlled trials[J]. Clinical Nutrition, 2021, 40(8): 4 915-4 931.
[50] JANGRA S, SHARMA R K, POTHURAJU R, et al. Milk fermented with Lactobacillus casei NCDC19 improves high fat and sucrose diet alters gene expression in obese mice[J]. International Dairy Journal, 2019, 90: 15-22.
[51] KADOOKA Y, SATO M, OGAWA A, et al. Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial[J]. British Journal of Nutrition, 2013, 110(9): 1 696-1 703.
[52] WANG C, LI S, SUN E, et al. Effects of fermented milk containing Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup) and MN-Gup-based synbiotics on obesity induced by high fat diet in rats[J]. Nutrients, 2022, 14(13): 2 631.
[53] 贺云, 杨丽霞, 邱连利. 从肠道微生态角度探讨2型糖尿病的发病机制以及治疗措施[J]. 中国实验方剂学杂志, 2020, 26(15): 229-234. HE Y, YANG L X, QIU L L. Discussion on pathogenesis and treatment of type 2 diabetes from perspective of intestinal microecology[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2020, 26(15): 229-234.
[54] 杨慧, 郭慧, 郝红伟, 等. 副干酪乳杆菌N1115发酵乳对Ⅱ型糖尿病人群血糖的影响[J]. 食品科技, 2018, 43(3): 14-19. YANG H, GUO H, HAO H W, et al. Effect on blood glucose of yogurt supplemented with probiotics N1115 in type 2 diabetes mellitus[J]. Food Science and Technology, 2018, 43(3): 14-19.
[55] YADAV R, DEY D K, VIJ R, et al. Evaluation of anti-diabetic attributes of Lactobacillus rhamnosus MTCC: 5957, Lactobacillus rhamnosus MTCC: 5897 and Lactobacillus fermentum MTCC: 5898 in streptozotocin induced diabetic rats[J]. Microbial Pathogenesis, 2018, 125: 454-462.
[56] 张海平, 李微, 李瑞英, 等. 益生菌发酵乳对糖尿病大鼠血糖水平和肠道菌群的影响[J]. 营养学报, 2018, 40(5): 454-458. ZHANG H P, LI W, LI R Y, et al. Effects of probiotic fermented milk on blood glucose levels and intestinal microbiota in diabetic rats[J]. Acta Nutrimenta Sinica, 2018, 40(5): 454-458.
[57] FEROLLA S M, DE ALMEIDA ARMILIATO G N, COUTO C A, et al. Probiotics as a complementary therapeutic approach in nonalcoholic fatty liver disease[J]. World Journal of Hepatology, 2015, 7(3): 559.
[58] 梁娇娇, 顾瑞霞, 陈大卫, 等. 鼠李糖乳杆菌hsryfm 1301发酵乳改善大鼠非酒精性脂肪肝特性研究[J]. 中国乳品工业, 2020, 48(5): 4-9, 14. LIANG J J, GU R X, CHEN D W, et al. Effect of Lactobacillus rhamnosus hsryfm 1301 fermented milk on the characteristics of nonalcoholic fatty liver in rats[J]. Dairy Industry, 2020, 48(5): 4-9, 14.
[59] 瞿恒贤. 鼠李糖乳杆菌LV108发酵乳对非酒精性脂肪肝病保护机制研究[D]. 扬州: 扬州大学, 2018: 30-56. QU H X. Protective mechanism of Lactobacillus rhamnose LV108 fermented milk against nonalcoholic fatty liver disease[D]. Yangzhou: Yangzhou Univeristy, 2018: 30-56.
[60] 努丽艳·阿不都米力克, 沙吉坦穆·克依斯尔, 阿依古扎·依布拉音, 等. 新疆传统发酵酸驼乳优势乳酸菌粘附性质及益生特性研究[J]. 食品与机械, 2016, 32(4): 42-46. NVLIYAN A, SHAJIMUTAN K, AYIGUZHA Y, et al. study on cell adhesion and probiotic characteristics of dominant lacticacid bacteria in traditional fermented camel milk-shubat[J]. Food & Machinery, 2016, 32(4): 42-46.
[61] 黄玉军, 梁文星, 刘冬, 等. 人源性发酵乳杆菌f5降解大鼠胆固醇的研究[J]. 食品与机械, 2013, 29(6): 5-9. HUANG Y J, LIANG W X, LIU D, et al. Effects on cholesterol-reducing of rats by Lactobacillus fermentum from human intestine[J]. Food & Machinery, 2013, 29(6): 5-9.
[62] 贺小龙, 姜铁民, 陈历俊, 等. 含母乳植物乳杆菌水牛乳酸奶的ACE抑制肽分布研究[J]. 中国食品添加剂, 2023, 4(2): 35-42. HE X L, JIANG T M, CHEN L J, et al. Distribution of ACE inhibitory peptides in buffalo milk yoghurtcontaining Lactobacillus plantarum[J]. China Food Additives, 2023, 34(2): 35-42.
[63] LI Y, HAO Y, FAN F, et al. The role of microbiome in insomnia, circadian disturbance and depression[J]. Frontiers in Psychiatry, 2018, 9: 669.
[64] KATO-KATAOKA A, NISHIDA K, TAKADA M, et al. Fermented milk containing Lactobacillus casei strain Shirota preserves the diversity of the gut microbiota and relieves abdominal dysfunction in healthy medical students exposed to academic stress[J]. Applied and Environmental Microbiology, 2016, 82(12): 3 649-3 658.
[65] WU Z, WANG P, PAN D, et al. Effect of adzuki bean sprout fermented milk enriched in γ-aminobutyric acid on mild depression in a mouse model[J]. Journal of Dairy Science, 2021, 104(1): 78-91.
[66] YU L, HAN X, CEN S, et al. Beneficial effect of GABA-rich fermented milk on insomnia involving regulation of gut microbiota[J]. Microbiological Research, 2020, 233: 126409.
[67] 朱慧越, 邹仁英, 许梦舒, 等. 短链脂肪酸—酰化淀粉对小鼠抑郁样行为的缓解及机制[J]. 食品与发酵工业, 2021, 47(6): 26-33. ZHU H Y, ZOU R Y, XU M S, et al. Short chain fatty acid-acylated starch alleviates depression-like behaviors in mice and its mechanisms[J]. Food and Fermentation Industries, 2021, 47(6): 26-33.
[68] MENG X, GAO Y, QI H, et al. Clinical application value of Lactobacillus Plantarum PS128 in patients with anxiety disorders[J]. Clin Psychopharmacol Neurosci, 2022, 20(3): 560-566.
[69] GAO Y, TAN L, YU J T, et al. Tau in Alzheimer's disease: Mechanisms and therapeutic strategies[J]. Current Alzheimer Research, 2018, 15(3): 283-300.
[70] AKBARI E, ASEMI Z, DANESHVAR KAKHAKI R, et al. Effect of probiotic supplementation on cognitive function and metabolic status in Alzheimer's disease: A randomized, double-blind and controlled trial[J]. Frontiers in Aging Neuroscience, 2016, 8: 256.
[71] 刘军莉, 刘川川, 李润乐, 等. 青海藏区发酵乳对阿尔茨海默病模型小鼠认知功能的影响[J]. 中国高原医学与生物学杂志, 2020, 41(2): 94-100. LIU L J, LIU C C, LI R H, et al. Effects of high-altitude tibetan fermented milk on cognitive function of alzheimer's disease model mice[J]. Chinese High Altitude Medicine and Biology, 2020, 41(2): 94-100.
[72] NAOMI R, EMBONG H, OTHMAN F, et al. Probiotics for Alzheimer's disease: A systematic review[J]. Nutrients, 2022, 14(1): 20.
[73] 彭超, 张艳, 米彩云, 等. 中医方药对阿尔茨海默病NF-κB信号通路调控的研究进展[J]. 中国中医基础医学杂志, 2021, 27(10): 1 675-1 679. PENG C, ZHANG Y, MI C Y, et al. Research progress on the regulation of NF-κB signal pathway in alzheimer's disease by Chinese medicine[J]. Journal of Basic Chinese Medicine, 2021, 27(10): 1 675-1 679.
[74] VAN DE WOUW M, WALSH C J, VIGANO G M D, et al. Kefir ameliorates specific microbiota-gut-brain axis impairments in a mouse model relevant to autism spectrum disorder[J]. Brain, Behavior, and Immunity, 2021, 97: 119-134.
[75] LU C, RONG J, FU C, et al. Overall rebalancing of gut microbiota is key to autism intervention[J]. Frontiers in Psychology, 2022, 13: 862719.
[76] ZHANG Y, GUO M, ZHANG H, et al. Lactiplantibacillus plantarum ST-III-fermented milk improves autistic-like behaviors in valproic acid-induced autism spectrum disorder mice by altering gut microbiota[J]. Frontiers in Nutrition, 2022, 9: 1005308.
[77] LIDDICOAT C, SYDNOR H, CANDO-DUMANCELA C, et al. Naturally-diverse airborne environmental microbial exposures modulate the gut microbiome and may provide anxiolytic benefits in mice[J]. Science of the Total Environment, 2020, 701: 134684.
[78] KRATSMAN N, GETSELTER D, ELLIOTT E. Sodium butyrate attenuates social behavior deficits and modifies the transcription of inhibitory/excitatory genes in the frontal cortex of an autism model[J]. Neuropharmacology, 2016, 102: 136-145.
[79] MONTANARI M, MARTELLA G, BONSI P, et al. Autism spectrum disorder: Focus on glutamatergic neurotransmission[J]. International Journal of Molecular Sciences, 2022, 23(7): 3 861.
[80] GHANIZADEH A. Increased glutamate and homocysteine and decreased glutamine levels in autism: A review and strategies for future studies of amino acids in autism[J]. Disease Markers, 2013, 35(5): 281-286.

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