Application progress of gas chromatography-mass spectrometry in food analysis

Authors

XING Qian-qian, Bright Dairy & Food Co., Ltd., State Key Laboratory of Dairy Biotechnology, Shanghai 200436, China;Bright Dairy & Food Co., Ltd., Shanghai Engineering Research Center of Dairy Biotechnology, Shanghai 200436, China;Synergetic Innovation Center for Food Safety and Nutrition, Jiangnan University, Wuxi, Jiangsu 214122, China
LIU Zhen-min, Bright Dairy & Food Co., Ltd., State Key Laboratory of Dairy Biotechnology, Shanghai 200436, China;Bright Dairy & Food Co., Ltd., Shanghai Engineering Research Center of Dairy Biotechnology, Shanghai 200436, China;Synergetic Innovation Center for Food Safety and Nutrition, Jiangnan University, Wuxi, Jiangsu 214122, China
HONG Qing, Bright Dairy & Food Co., Ltd., State Key Laboratory of Dairy Biotechnology, Shanghai 200436, China;Bright Dairy & Food Co., Ltd., Shanghai Engineering Research Center of Dairy Biotechnology, Shanghai 200436, China;Synergetic Innovation Center for Food Safety and Nutrition, Jiangnan University, Wuxi, Jiangsu 214122, China
YOU Chun-ping, Bright Dairy & Food Co., Ltd., State Key Laboratory of Dairy Biotechnology, Shanghai 200436, China;Bright Dairy & Food Co., Ltd., Shanghai Engineering Research Center of Dairy Biotechnology, Shanghai 200436, China;Synergetic Innovation Center for Food Safety and Nutrition, Jiangnan University, Wuxi, Jiangsu 214122, ChinaFollow

Corresponding Author(s)

游春苹（1982—），女，光明乳业股份有限公司教授级高工，博士。E-mail: youchunping@brightdairy.com

Abstract

Gas chromatography-mass spectrometry combines the advantages of efficient and rapid gas chromatography and accurate identification by mass spectrometry. Gas chromatography-mass spectrometry has been widely used in the separation and analysis of volatile components in food recently. This paper reviewed the application progress of GC in food analysis, introduces the separation mechanism of GC, the types of GC columns and the classification of detectors. The application progress of GC-MS in food analysis was reviewed, and the separation process of gas chromatography, the classification of chromatographic columns and the classification of detectors were introduced. Moreover, the applications of gas chromatography-mass spectrometry in food nutrition, food safety and food traceability were discussed in detail with specific examples.

Publication Date

10-20-2023

First Page

234

Last Page

240

DOI

10.13652/j.spjx.1003.5788.2022.80787

Recommended Citation

Qian-qian, XING; Zhen-min, LIU; Qing, HONG; and Chun-ping, YOU (2023) "Application progress of gas chromatography-mass spectrometry in food analysis," Food and Machinery: Vol. 39: Iss. 6, Article 35.
DOI: 10.13652/j.spjx.1003.5788.2022.80787
Available at: https://www.ifoodmm.cn/journal/vol39/iss6/35

References

[1] 钱敏, 刘坚真, 白卫东. 气质联用仪在食品工业中的应用[J]. 中国调味品, 2009, 34（9）: 101-108. QIAN M, LIU J Z, BAI W D. The application of GC-MS on food industry[J]. China Condiment, 2009, 34（9）: 101-108.
[2] 史珊珊. 气相色谱技术在粮油食品质量检测中的运用研究[J]. 食品安全导刊, 2022（10）: 160-162. SHI S S. Research on the application of gas chromatography in the quality inspection of grain, oil and food stuffs[J]. China Food Safety Magazine, 2022（10）: 160-162.
[3] 黄一承, 仲美桥, 韩妍, 等. 发酵食品风味物质形成及前处理方法研究进展[J]. 中国调味品, 2022, 47（8）: 205-209. HUANG Y C, ZHONG M Q, HAN Y, et al. Research progress on flavor compound formation and pretreatment methods of fermented food[J]. China Condiment, 2022, 47（8）: 205-209.
[4] WANG S, CHEN H, SUN B. Recent progress in food flavor analysis using gas chromatography-ion mobility spectrometry （GC-IMS）[J]. Food Chem, 2020, 315: 126158.
[5] 宋菁景, 刘雪, 林小晖. 色谱—质谱联用技术在食品检测中的应用[J]. 食品安全导刊, 2022（6）: 180-183. SONG J J, LIU X, LIN X H. Application of chromatography-mass spectrometry in food detection[J]. China Food Safety Magazine, 2022（6）: 180-183.
[6] LEHOTAY S J, HAJLOV J. Application of gas chromatography in food analysis[J]. TrAC Trends in Analytical Chemistry, 2002, 21（9）: 686-697.
[7] 许建军, 陆进宇, 张晔. 气相色谱仪检定中色谱柱的选择[J]. 化学分析计量, 2019, 28（8）: 63-66. XU J J, LU J Y, ZHANG Y. Selection of chromatographic columns in the verification of gas chromatograph[J]. Chemical Analysis and Meterage, 2019, 28（8）: 63-66.
[8] 陆智. 气相色谱—质谱指纹图谱结合聚类分析在薄荷香精风味品质稳定性分析中的应用[J]. 现代食品科技, 2018, 34（9）: 283-290. LU Z. Evaluation of flavor quality stability of peppermint essential oils using gas chromatography-mass spectrometry fingerprints in combination with cluster analysis[J]. Modern Food Science and Technology, 2018, 34（9）: 283-290.
[9] 司露露, 梁杨琳, 吕春秋, 等. QuEChERS-气相色谱—串联质谱法和高效液相色谱—串联质谱法快速检测蔬菜中267种香港规例中的农药残留量[J]. 食品安全质量检测学报, 2021, 12（1）: 122-136. SI L L, LIANG Y L, LU C Q, et al. Rapid determination of 267 kinds of Hong Kong regulatory pesticide residues in vegetables by QuEChERS combined with gas chromatographytandem mass spectrometry and high performance liquid chromatography-tandem mass spectrometry[J]. Journal of Food Safety and Quality, 2021, 12（1）: 122-136.
[10] 崔连喜, 王艳丽. 吸附管采样—热脱附/气相色谱质谱法测定环境空气中5种有机硫化物[J]. 化工环保, 2021, 41（4）: 518-523. CUI L X, WANG Y L. Determination of 5 organic sulfides in ambient air by adsorption tube sampling-thermal desorption-gas chromatography-mass spectrometry[J]. Environmental Protection of Chemical Industry, 2021, 41（4）: 518-523.
[11] 傅若农. 近两年国内气相色谱的应用进展（Ⅲ）[J]. 分析试验室, 2005, 24（6）: 77-92. FU R N. Advances on gas chromatography in China in recent two years（Ⅲ）[J]. Chinese Journal of Analysis Laboratory, 2005, 24（6）: 77-92.
[12] 张蓓, 何浩, 吴海智, 等. 顶空—气相色谱法测定婴幼儿配方食品和辅助食品中亚硝酸盐[J]. 中国乳品工业, 2022, 50（2）: 54-58. ZHANG B, HE H, WU H Z, et al. Determination of nitrite in infant formula food and supplementary food for infants and children by headspace gas chromatography[J]. China Dairy Industry, 2022, 50（2）: 54-58.
[13] 徐大玮, 毕玉琦, 解恒杰, 等. 基于气相色谱的7种食品添加剂并行检测技术[J]. 粮食与饲料工业, 2022（4）: 57-61. XU D W, BI Y Q, XIE H J, et al. Parallel detection technology of seven food additives based on gas chromtography[J]. Cereal & Feed Industry, 2022（4）: 57-61.
[14] 张瑶, 吴龙国, 马桂娟, 等. 气相色谱—串联质谱结合固相萃取技术同时测定番茄和黄瓜中10种杀菌剂[J]. 食品与机械, 2020, 36（7）: 67-71. ZHANG Y, WU L G, MA G J, et al. Stimultaneous determination of 10 kinds of fungicides in tomatoes and cucumbers by GC-MS/MS combined with solid phase extraction[J]. Food & Machinery, 2020, 36（7）: 67-71.
[15] D'ORAZIO G, HERNNDEZ-BORGES J, HERRERA-HERRERA A V, et al. Determination of estrogenic compounds in milk and yogurt samples by hollow-fibre liquid-phase microextraction-gas chromatography-triple quadrupole mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2016, 408（26）: 7 447-7 459.
[16] ALHOOSHANI K. Determination of chlorinated hydrocarbons in milk samples using sol-gel based polymer coated silica sorbent for stir-bar supported micro-solid-phase extraction coupled with gas chromatography mass-spectrometry[J]. Journal of Saudi Chemical Society, 2019, 23（6）: 702-710.
[17] JARIYASOPIT N, KHAMSAENG S, PANYA A, et al. Quantitative analysis of nutrient metabolite compositions of retail cow's milk and milk alternatives in Thailand using GC-MS[J]. Journal of Food Composition and Analysis, 2021, 97: 103785.
[18] PARIS A, LEDAUPHIN J, LOPEZ C, et al. Trace amount determination of monocyclic and polycyclic aromatic hydrocarbons in fruits: Extraction and analytical approaches[J]. Journal of Food Composition and Analysis, 2018, 67: 110-118.
[19] 刘通, 王玉娇, 王秀娟, 等. 气相色谱—三重四极杆质谱法同时测定巴氏杀菌乳中9种香精成分[J]. 色谱, 2019, 37（11）: 1 215-1 220. LIU T, WANG Y J, WANG X J, et al. Stimulataneous detemination of nine flavor compounds in pasteurized milk by gas chromatography-triple quadrupole mass spectrometry[J]. Chinese Journal of Chromatography, 2019, 37（11）: 1 215-1 220.
[20] ASENSIO E, URANGA J, NERN C. Analysis of potential migration compounds from silicone molds for food contact by SPME-GC-MS[J]. Food and Chemical Toxicology, 2022, 165: 113130.
[21] 李佳, 刘忠义, 付满, 等. 发酵香肠风味物质气质分析及与发酵时间的关系[J]. 食品与机械, 2019, 35（5）: 61-66. LI J, LIU Z Y, FU M, et al. The flavor compounds in fermented sausages analyzed by GC-MS and its relationship with fermentation time[J]. Food & Machinery, 2019, 35（5）: 61-66.
[22] 徐文泱, 陈华. 气—质联用法同时检测高脂食品中14种光引发剂[J]. 食品与机械, 2018, 34（8）: 54-59. XU W Y, CHEN H. GC/MS for simultaneous determination of 14 photo-initiators in fatty food[J]. Food & Machinery, 2018, 34（8）: 54-59.
[23] 陈国通, 芦云, 马萍萍, 等. 基于HS-SPME-GC-MS的薰衣草不同部位挥发性成分分析[J]. 食品与机械, 2022, 38（7）: 37-42. CHEN G T, LU Y, MA P P, et al. Analysis of volatile components in different parts of lavender based on HS-SPME-GC-MS[J]. Food & Machinery, 2022, 38（7）: 37-42.
[24] 杨祺福, 徐文思, 胡思思, 等. 基于HS-SPME-GC-MS的小龙虾加工水煮液中挥发性风味成分萃取条件优化[J]. 食品与机械, 2022, 38（2）: 57-63. YANG Q F, XU W S, HU S S, et al. Optimization of extraction conditions for volatile flavor compounds in crayfish boiled liquid based on HS-SPME-GC-MS[J]. Food & Machinery, 2022, 38（2）: 57-63.
[25] 闫实, 赵辉, 张静, 等. 气质联用检测蔬菜中7种有机磷类农药残留量检出研究[J]. 农业环境科学学报, 2008, 27（1）: 390-394. YAN S, ZHAO H, ZHANG J, et al. Determination of seven kinds of organophosphorus pesticides residue in vegetables by GC/MS[J]. Journal of Agro-Environment Science, 2008, 27（1）: 390-394.
[26] 冯恒. 鳕鱼产品的快速鉴别及其脂质,风味物质的研究[D]. 杭州: 浙江工商大学, 2020: 50-62. FENG H. Rapid identification of cod products and study on their lipids and flavor sudstances[D]. Hangzhou: Zhejiang Gongshang University, 2020: 50-62.
[27] CUI Y, SHI X, TANG Y, et al. The effects of heat treatment and fermentation processes on the formation of furfurals in milk-based dairy products using a QuEChERS technique followed by gas chromatography coupled with triple quadrupole mass spectrometry[J]. Food Chemistry, 2020, 313: 125930.
[28] HAN Y, DU J, SONG Z. Effects of the yeast endogenous β-glucosidase on hawthorn （Crataegus pinnatifida Bunge） wine ethyl carbamate and volatile compounds[J]. Journal of Food Composition and Analysis, 2021, 103: 104084.
[29] 刘芸, 曾广丰, 刘桂华, 等. 顶空—气相色谱质谱法测定食品接触材料中18种丙烯酸酯和甲基丙烯酸酯类的迁移量[J]. 食品安全质量检测学报, 2021, 12（14）: 5 519-5 526. LIU Y, ZENG G F, LIU G H, et al. Determination of themigration amount of 18 kinds of acrylate and methacrylates in food contact materials by headspace-gas chromatography mass spectrometry[J]. Journal of Food Safety and Quality, 2021, 12（14）: 5 519-5 526.
[30] 刘伟, 欧阳艳, 陈芳媛, 等. FFAP毛细管柱气相色谱法测定酒中香味成分的初步探究[J]. 伊犁师范学院学报（自然科学版）, 2014, 8（3）: 48-51. LIU W, OUYANG Y, CHEN F Y, et al. Preliminary study on the determination of aroma components in wine by FFAP capillary column gas chromatography[J]. Journal of Yili Normal University （Natural Science Edition）, 2014, 8（3）: 48-51.
[31] CUTHBERTSON D, ANDREWS P K, REGANOLD J P, et al. Utility of metabolomics toward assessing the metabolic basis of quality traits in apple fruit with an emphasis on antioxidants[J]. Journal of Agricultural and Food Chemistry, 2012, 60（35）: 8 552-8 560.
[32] ARBULU M, SAMPEDRO M C, SANCHEZ-ORTEGA A, et al. Characterisation of the flavour profile from Graciano Vitis vinifera wine variety by a novel dual stir bar sorptive extraction methodology coupled to thermal desorption and gas chromatography-mass spectrometry[J]. Analytica Chimica Acta, 2013, 777: 41-48.
[33] OTERI M, RIGANO F, MICALIZZI G, et al. Comparison of lipid profile of Italian extra virgin olive oils by using rapid chromatographic approaches[J]. Journal of Food Composition and Analysis, 2022, 110: 104531.
[34] 陆羽霜. 基于¹H-NMR和GC-MS代谢组学方法评估加工对黑胡萝卜化学成分的影响[D]. 杭州: 浙江工商大学, 2020: 43-58. LU Y S. Based on ¹H-NMR and GC-MS metabolomics approach to understanding the processing effects on the chemical in black carrots[D]. Hangzhou: Zhejiang Gongshang University, 2020: 43-58.
[35] JO Y, BENOIST D M, BARBANO D M, et al. Flavor and flavor chemistry differences among milks processed by high-temperature, short-time pasteurization or ultra-pasteurization[J]. Journal of Dairy Science, 2018, 101（5）: 3 812-3 828.
[36] HERNNDEZ F, PORTOLS T, PITARCH E, et al. Gas chromatography coupled to high-resolution time-of-flight mass spectrometry to analyze trace-level organic compounds in the environment, food safety and toxicology[J]. TrAC Trends in Analytical Chemistry, 2011, 30（2）: 388-400.
[37] YASIEN S, IQBAL M M, JAVED M, et al. Quantification of multi-class pesticides in stomach contents and milk by gas chromatography-mass spectrometry with liquid extraction method[J]. Arabian Journal of Chemistry, 2022, 15（7）: 103937.
[38] 刘思维, 吴敏, 耿灵鑫. 气质法测定食品中甜蜜素的含量方法探讨[J]. 食品安全导刊, 2020（18）: 103. LIU S W, WU M, GENG L X. Discussion on the method for determination of sodium cyclamate in food by gas spectrometry[J]. China Food Safety, 2020（18）: 103.
[39] 程燕. 乳制品中双酚类物质及其环氧衍生物的检测方法研究[D]. 上海: 华东理工大学, 2017: 14-25. CHENG Y. The study on the detection methods of bisphenols, bisphenols digycidyl ethers and their derivatives in dairy products[D]. Shanghai: East China University of Science and Technology, 2017: 14-25.
[40] 周松华, 林勤保, 李波, 等. 气相色谱—质谱联用检测聚丙烯食品包装材料中的18种有毒有害物质[J]. 包装与食品机械, 2015, 33（1）: 56-62. ZHOU S H, LIN Q B, LI B, et al. Determination of 18 substances in polypropylene food packaging materials by gas chromatography-mass spectrometry[J]. Packaging and Food Machinery, 2015, 33（1）: 56-62.
[41] 张慧艳, 刘诗文, 齐诗哲, 等. 食品组学技术在食品真伪鉴别和溯源方面应用进展[J]. 食品安全质量检测学报, 2022, 13（3）: 948-955. ZHANG H Y, LIU S W, QI S Z, et al. Application progress of food omics technology in food authenticity identification and traceability[J]. Journal of Food Safety and Quality, 2022, 13（3）: 948-955.
[42] LIU F, GRAUWET T, KEBEDE B T, et al. Comparing the effects of high hydrostatic pressure and thermal processing on blanched and unblanched mango （Mangifera indica L.） nectar: Using headspace fingerprinting as an untargeted approach[J]. Food and Bioprocess Technology, 2014, 7（10）: 3 000-3 011.
[43] BELEGGIA R, MENGA V, PLATANI C, et al. Metabolomic analysis can detect the composition of pasta enriched with fibre after cooking[J]. Journal of the Science of Food and Agriculture, 2016, 96（9）: 3 032-3 041.
[44] LEE A P, BARBANO D M, DRAKE M A. The influence of ultra-pasteurization by indirect heating versus direct steam injection on skim and 2% fat milks[J]. Journal of Dairy Science, 2017, 100（3）: 1 688-1 701.
[45] GIANNETTI V, BOCCACCI MARIANI M, MANNINO P, et al. Volatile fraction analysis by HS-SPME/GC-MS and chemometric modeling for traceability of apples cultivated in the Northeast Italy[J]. Food Control, 2017, 78: 215-221.
[46] CAJKA T, RIDDELLOVA K, KLIMANKOVA E, et al. Traceability of olive oil based on volatiles pattern and multivariate analysis[J]. Food Chemistry, 2010, 121（1）: 282-289.
[47] CASTRO-PUYANA M, PREZ-MGUEZ R, MONTERO L, et al. Reprint of: Application of mass spectrometry-based metabolomics approaches for food safety, quality and traceability[J]. TrAC Trends in Analytical Chemistry, 2017, 96: 62-78.