Abstract
［Objective］ Seeking a comprehensive therapeutic approach to address multiple pathological processes in Diabetic Cardiomyopathy (DCM ).［Methods］ Randomly divided all mice into control group,DCM group,DCM +PFTJ group,DCM +HIIT group,and DCM +PFTJ +HIIT group.Used intraperitoneal injection of streptozotocin combined with high -fat diet to treat mice,and treated them according to the experimental plan for 16 weeks.Recorded the heart weight to body weight ratio (HW/BW ),detected cardiac function using small animal ultrasound imaging system,and assessed the pathological damage of the heart by detecting the levels of lactate dehydrogenase (LDH ),creatine kinase (CK),troponin I,IL-6,IL-1β,and TNF -α in the serum,combined with hematoxylin and eosin staining.At the same time,detected the expression of NLRP 3 and Cleaved caspase -1 proteins in the myocardial tissue.［Results］］ Compared with the DCM group,the degree of myocardial fiber disarray and myocardial fibrosis in mice of the DCM +PFTJ group and DCM +HIIT group was significantly reduced,with the DCM +PFTJ +HIIT group showing the best effected in improving myocardial structure.Cardiac function indicators (left ventricular ejection fraction and fractional shortening ) were improved in the DCM +PFTJ group and DCM +HIIT group,with the DCM +PFTJ +HIIT group showing a more significant effect;the HW/BW of mice in the DCM +PFTJ +HIIT group increased,and the levels of LDH,CK,troponin I,IL-6,IL-1β,and TNF -α in the serum were significantly decreased.In their myocardial tissue,the expression levels of NLRP 3 and Cleaved caspase -1 proteins were also significantly reduced.［Conclusion］ The combination of PFTJ and HIIT significantly |improves the cardiac condition of DCM mice by improving cardiac function and myocardial damage,and its possible mechanism may be related to the inhibition of the NLRP 3 inflammasome.
Publication Date
2-18-2025
First Page
166
Last Page
171
DOI
10.13652/j.spjx.1003.5788.2024.80865
Recommended Citation
Yahui, LI
(2025)
"The improving effects of probiotic fermented tomato juice combined with high-intensity interval training on diabetic cardiomyopathy in mice,"
Food and Machinery: Vol. 40:
Iss.
11, Article 23.
DOI: 10.13652/j.spjx.1003.5788.2024.80865
Available at:
https://www.ifoodmm.cn/journal/vol40/iss11/23
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