Abstract
Objective: Modified starch was used to mix with gelatin to prepare the capsule shell, and the cost of preparing the capsule shell was reduced. Methods: Oxidized corn starch prepared by using 15% hydrogen peroxide was used as raw material to mix with part of gelatin. The oxidized corn starch/gelatin composite film and capsules were prepared by casting method and impregnation method, respectively, and were characterized by Fourier transform infrared spectroscopy （FT-IR）, X-ray diffraction （XRD） and Scanning electron microscopy （SEM）. Results: The results showed that the ratio of oxidized corn starch and gelatin was 5∶5, the drying weight loss of oxidized corn starch/gelatin composite capsules was 13.0%～15.0%, the disintegration time in distilled water and simulated artificial gastric juice was less than 10min, and the crunchability was not more than 5 granules. Conclusion: The properties of the composite capsule prepared by blending oxidized corn starch with gelatin met the requirements of Chinese Pharmacopoeia （2020）.
Publication Date
7-22-2024
First Page
188
Last Page
193
DOI
10.13652/j.spjx.1003.5788.2024.60023
Recommended Citation
Xin, TAN; Chunyan, LIANG; Songlin, DENG; Qijie, CHEN; and Yongqing, LUO
(2024)
"Preparation and characterization of oxidized corn starch/gelatin composite capsules,"
Food and Machinery: Vol. 40:
Iss.
5, Article 27.
DOI: 10.13652/j.spjx.1003.5788.2024.60023
Available at:
https://www.ifoodmm.cn/journal/vol40/iss5/27
References
[1] 郭华, 史泽毅, 张海霞, 等. 明胶—柠檬酸—硬脂酸复合凝胶的制备及性能[J]. 现代食品科技, 2021, 37（10）: 171-179, 307.
GUO H, SHI Z Y, ZHANG H X, et al. Preparation and properties of gelatin-citric acid-stearic acid composite gel[J]. Modern Food Science and Technology, 2021, 37（10）: 171-179, 307.
[2] 潘博, 贾雪, 支朝晖, 等. 复合改性淀粉膜材料工艺优化与性能分析[J]. 现代食品科技, 2020, 36（9）: 156-163.
PAN B, JIA X, ZHI Z H, et al. Process optimization and performance analysis of composite modified starch membrane materials[J]. Modern Food Science and Technology, 2020, 36（9）: 156-163.
[3] AHMED M A, AL-KAHTANI H A, JASWIR I, et al. Extraction and characterization of gelatin from camel skin （potential halal gelatin） and production of gelatin nanoparticles[J]. Saudi Journal of Biological Sciences, 2020, 27（6）: 1 596-1 601.
[4] LI Y, WANG J H, WANG E C, et al. The microstructure and thermal properties of pulsed electric field pretreated oxidized starch[J]. International Journal of Biological Macromolecules, 2023, 235: 123721.
[5] 王向峰, 章家伟, 帅放文, 等. 羟丙基淀粉取代度对淀粉空心胶囊性能的影响[J]. 中国新药杂志, 2017, 26（24）: 2 984-2 988.
WANG X F, ZHANG J W, SHUAI F W, et al. The effect of hydroxypropyl starch substitution degree on the performance of starch hollow capsules[J]. Chinese Journal of New Drugs, 2017, 26（24）: 2 984-2 988.
[6] 何绍凯, 刘文娟, 曹余, 等. 酶解羟丙基马铃薯淀粉的制备及其在空心胶囊中的应用[J]. 食品工业科技, 2017, 38（6）: 163-167.
HE S K, LIU W J, CAO J, et al. Preparation of enzymatic hydrolyzed hydroxypropyl potato starch and the application in hollow capsules[J]. Science and Technology of Food Industry, 2017, 38（6）: 163-167.
[7] 陈启杰, 赵雅兰, 踪张扬, 等. 绿豆淀粉/纤维素纳米晶胶囊壳的制备及表征[J]. 中国食品学报, 2022, 22（8）: 182-189.
CHEN Q J, ZHAO Y L, ZONG Z Y, et al. Preparation and characterization of mung bean starch/cellulose nanocrystalline capsule shells[J]. Journal of Chinese Institute of Food Science and Technology, 2022, 22（8）: 182-189.
[8] MORENO O, CRDENAS J, ATARS L, et al. Influence of starch oxidation on the functionality of starch-gelatin based active films[J]. Carbohydrate Polymers, 2017, 178: 147-158.
[9] ZHANG N Z, LIU H S, YU L, et al. Developing gelatin-starch blends for use as capsule materials[J]. Carbohydrate Polymers, 2013, 92（1）: 455-461.
[10] 宿玲恰, 吴敬. 淀粉基未来食品及其制备方法研究进展[J]. 食品与生物技术学报, 2021, 40（12）: 5-16.
SU L Q, WU J. Research progress on starch based future foods and their preparation methods[J]. Journal of Food and Biotechnology, 2021, 40（12）: 5-16.
[11] ZHANG Y P, ZHAO Q, WANG H S, et al. Preparation of green and gelatin-free nanocrystalline cellulose capsules[J]. Carbohydrate Polymers, 2017, 164: 358-363.
[12] 黄峻榕, 唐晓东, 蒲华寅. 淀粉凝胶的微观结构、质构及稳定性研究进展[J]. 食品与生物技术学报, 2017, 36（7）: 673-679.
HUANG J R, TANG X D, PU H Y. Research progress on microstructure, texture and stability of starch gel[J]. Journal of Food and Biotechnology, 2017, 36（7）: 673-679.
[13] MARIIA K, ARIF M, DING Y, et al. Preparation of novel hard capsule using water-soluble polysaccharides and cellulose nanocrystals for drug delivery[J]. Journal of Pharmaceutical Innovation, 2022, 18（2）: 675-686.
[14] PUTRO J N, SOETAREDJO F E, LUNARDI V B, et al. Polysaccharides gums in drug delivery systems: A review[J]. International Journal of Biological Macromolecules, 2023, 253: 127020.
[15] SCOPEL B S, RIBEIRO M E, DETTMER A, et al. Cornstarch-gelatin films: Commercial gelatin versus chromed leather waste gelatin and evaluation of drying conditions[J]. Journal of Polymers and the Environment, 2017, 26（5）: 1 998-2 006.
[16] DANG X G, SHAN Z H, CHEN H. The preparation and applications of one biodegradable liquid film mulching by oxidized corn starch-gelatin composite[J]. Applied Biochemistry and Biotechnology, 2016, 180（5）: 917-929.
[17] ZHANG Y H, YANG N, ZHANG Y Q, et al. Effects of κ-carrageenan on pullulan's rheological and texture properties as well as pullulan hard capsule performances[J]. Carbohydrate Polymers, 2020, 238: 116190.
[18] GARCIA M A V T, GARCIA C F, FARACO A A G. Pharmaceutical and biomedical applications of native and modified starch: A review[J]. Starch, 2020, 72（7/8）: 1900270.