Research progress on the nutritional composition, biological activity, and application of Ganoderma lucidum

Authors

CHEN Yijun, School of Environmental and Food Engineering, Liuzhou Vocational & Technical College, Liuzhou, Guangxi 545006, ChinaFollow
YANG Xiaomei, Institute of Food Research, Hezhou University, Hezhou, Guangxi 542899, China
LIN Lihua, School of Environmental and Food Engineering, Liuzhou Vocational & Technical College, Liuzhou, Guangxi 545006, China

Abstract

Ganoderma lucidum has anti-tumor, antioxidant, and immune enhancing effects. This review summarized the latest research progress on the main nutritional components and biological activities of G. lucidum and the current comprehensive utilization status of G. lucidum in medical and health fields, analyzed the existing problems, and prospected the future development direction of G. lucidum.

Publication Date

7-22-2024

First Page

227

Last Page

232

DOI

10.13652/j.spjx.1003.5788.2023.81145

Recommended Citation

Yijun, CHEN; Xiaomei, YANG; and Lihua, LIN (2024) "Research progress on the nutritional composition, biological activity, and application of Ganoderma lucidum," Food and Machinery: Vol. 40: Iss. 6, Article 32.
DOI: 10.13652/j.spjx.1003.5788.2023.81145
Available at: https://www.ifoodmm.cn/journal/vol40/iss6/32

References

[1] LIU Y Z, WANG Z M, ZHANG J Z. Dietary Chinese herbs: chemistry, pharmacology and clinical evidence[M]. Vienna: Springer, 2015: 3.
[2] 亓小妮, 谢苗, 吴杨洋, 等. 灵芝三萜化合物的制备与药理活性研究进展[J]. 安徽农业科学, 2021, 49（5）: 38-42. QI X N, XIE M, WU Y Y, et al. Research progress on preparation and pharmacological activities of Ganoderma lucidum triterpenes[J]. Journal of Anhui Agricultural Sciences, 2021, 49（5）: 38-42.
[3] 廖敏会, 宁鄢笑, 杨珍, 等. 贵州部分地区灵芝及其种植土壤中几种重金属污染检测[J]. 食药用菌, 2020, 28（5）: 314-317, 331. LIAO M H, NING Y X, YANG Z, et al. Detection and pollution evaluation of heavy metals in Ganoderma lucidum and its planting soil in partial areas of Guizhou Province[J]. Edible and Medicinal Mushrooms, 2020, 28（5）: 314-317, 331.
[4] SHEN S F, ZHU L F, WU Z J, et al. Extraction of triterpenoid compounds from Ganoderma lucidum spore powder through a dual-mode sonication process[J]. Drug Development and Industrial Pharmacy, 2020, 46（6）: 963-974.
[5] LI Y H, TANG J, GAO H L, et al. Ganoderma lucidum triterpenoids and polysaccharides attenuate atherosclerotic plaque in high-fat diet rabbits[J]. Nutrition, Metabolism and Cardiovascular Diseases, 2021, 31（6）: 1 929-1 938.
[6] JIN H, SONG C Y, ZHAO Z G, et al. Ganoderma lucidum polysaccharide, an extract from Ganoderma lucidum, exerts suppressive effect on cervical cancer cell malignancy through mitigating epithelial-mesenchymal and JAK/STAT5 signaling pathway[J]. Pharmacology, 2020, 105（7/8）: 461-470.
[7] SUSILO R J K, WINARNI D, HUSEN S A, et al. Hepatoprotective effect of crude polysaccharides extracted from Ganoderma lucidum against carbon tetrachloride-induced liver injury in mice[J]. Veterinary World, 2019, 12（12）: 1 987-1 991.
[8] RYU D H, CHO J Y, SADIQ N B, et al. Optimization of antioxidant, anti-diabetic, and anti-inflammatory activities andganoderic acid content of differentially dried Ganoderma lucidum using response surface methodology[J]. Food Chemistry, 2020, 335: 127645.
[9] OPATTOVA A, HORAK J, VODENKOVA S, et al.Ganoderma lucidum induces oxidative DNA damage and enhances the effect of 5-fluorouracil in colorectal cancer in vitro and in vivo[J]. Mutation Research, 2019, 845: 403065.
[10] LI Q Z, CHANG Y Z, HE Z M, et al. Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling pathways in RAW264.7 cells[J]. Journal of Cellular Physiology, 2019, 234（12）: 23 337-23 348.
[11] 柳小兰, 梁光焰, 杨莹, 等. 黔产赤灵芝不同部位无机元素和营养成分分析[J]. 信阳师范学院学报（自然科学版）, 2023, 36（1）: 39-45. LIU X L, LIANG G Y, YANG Y, et al. Analysis of inorganic elements and nutrient components in different parts of Ganoderma Lucidum from Guizhou[J]. Journal of Xinyang Normal University （Natural Science Edition）, 2023, 36（1）: 39-45.
[12] 孟楠楠, 弓志青, 杨正友, 等. 山东省灵芝子实体及孢子粉中营养成分比较[J]. 食品工业, 2019, 40（10）: 319-322. MENG N N, GONG Z Q, YANG Z Y, et al. Comparison of nutritional components in fruiting bodies and spore powder of Ganoderma lucidum in Shandong Province[J]. The Food Industry, 2019, 40（10）: 319-322.
[13] SETO S W, LAM T Y, TAM H L, et al. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic （＋db/＋db） mice[J]. Phytomedicine, 2009, 16（5）: 426-436.
[14] FERREIRA I C, HELENO S A, REIS F S, et al. Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities[J]. Phytochemistry, 2015, 114: 38-55.
[15] 郭爱玲, 宁慧娟, 秦子芳, 等. 不同栽培方式对赤灵芝多糖的影响[J]. 中国食用菌, 2018, 37（3）: 47-51. GUO A L, NING H J, QIN Z F, et al. Effect of different cultivation methods on polysaccharides of Ganoderma lucidum[J]. Edible Fungi of China, 2018, 37（3）: 47-51.
[16] 郭金英, 朱优优, 刘贵巧, 等. 不同品种灵芝主要活性成分与营养物质比较分析[J]. 北方园艺, 2017（17）: 177-180. GUO J Y, ZHU Y Y, LIU G Q, et al. Comparative analysis on active ingredients and nutrients of different varieties of Ganoderma lucidum[J]. Northern Horticulture, 2017（17）: 177-180.
[17] AKIHISA T, NAKAMURA Y, TAGATA M, et al. Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum[J]. Chemistry & Biodiversity, 2007, 4（2）: 224-231.
[18] CHEN S, YONG T, ZHANG Y, et al. Anti-tumor and anti-angiogenic ergosterols from Ganoderma lucidum[J]. Frontiers in Chemistry, 2017, 85: 1-12.
[19] WU H H, TANG S S, HUANG Z Q, et al. Hepatoprotective effects and mechanisms of action of triterpenoids from lingzhi or reishi medicinal mushroom Ganoderma lucidum （Agaricomycetes） on alpha-amanitin-induced liver injury in mice[J]. International Journal of Medicinal Mushrooms, 2016, 18（9）: 841-850.
[20] BHARADWAJ S, LEE K E, DWIVEDI V D, et al. Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against dengue virus NS2B-NS3 protease[J]. Sci Rep, 2019, 9（1）: 19059.
[21] 赵佳敏, 陈泓鑫, 林宇冲, 等. 灵芝三萜的提取工艺及其抗氧化研究进展[J]. 安徽化工, 2021, 47（1）: 11-12, 16. ZHAO J M, CHEN H X, LIN Y C, et al. Study progress of Triterpene extraction technology and its antioxidant[J]. Anhui Chemical Industry, 2021, 47（1）: 11-12, 16.
[22] 周旭, 庄思远, 李彦杰, 等. 赤灵芝中三萜类活性成分的提取筛选和质谱分析[J]. 现代食品科技, 2022, 38（6）: 169-178. ZHOU X, ZHUANG S Y, LI Y J, et al. Extraction, screening and mass spectrometry analysis of active Triterpenoid components in Ganoderma lucidum[J]. Modern Food Science and Technology, 2022, 38（6）: 169-178.
[23] 王波, 陈建新, 林剑豪, 等. 灵芝中灵芝三萜的提取方法研究[J]. 广州化学, 2022, 47（6）: 83-88. WANG B, CHEN J X, LIN J H, et al. Study on the extraction method of Ganoderma triterpenoids from Ganoderma lucidum[J]. Guangzhou Chemistry, 2022, 47（6）: 83-88.
[24] LIU T, ZHOU J C, LI W X, et al. Effects of sporoderm-broken spores of Ganoderma lucidum on growth performance, antioxidant function and immune response of broilers[J]. Animal Nutrition, 2020, 6（1）: 39-46.
[25] 王刚, 连紫宛, 李占强, 等. 雪灵芝粗多糖对S180荷瘤小鼠免疫功能的影响[J]. 中国野生植物资源, 2021, 40（3）: 33-37. WANG G, LIAN Z Y, LI Z Q, et al. Effect of crude polysaccharide from Arenaria kansuensis Maxim on immune function in Sarcoma 180 tumor-bearing mice[J]. Chinese Wild Plant Resources, 2021, 40（3）: 33-37.
[26] 苗景, 何祥波, 方邵明, 等. 基于转录组测序的灵芝多糖对公羊羔肝脏免疫功能的影响[J]. 黑龙江畜牧兽医, 2021（6）: 118-123, 149. MIAO J, HE X B, FANG S M, et al. Effect of Ganoderma lucidum polysaccharides on liver immune function of male lambs based on transcriptome sequencing[J]. Heilongjiang Animal Science and Veterinary Medicine, 2021（6）: 118-123, 149.
[27] 刘月环, 么春艳, 吴旧生. 灵芝三萜酸经Pnpla3基因的降脂效果体外试验: 基于长爪沙鼠肝原代细胞的脂变模型[J]. 中国比较医学杂志, 2021, 31（3）: 16-22. LIU Y H, YAO C Y, WU J S. Lipid-lowering effect of Ganoderma lucidum triterpene acid （GLTA） via Pnpla3: an in vitro steatosis model in liver parenchyma cells of the Mongolian gerbil[J]. Chinese Journal of Comparative Medicine, 2021, 31（3）: 16-22.
[28] 李亚晗, 刘佳琳, 王天添, 等. 灵芝多糖抗肿瘤免疫调节机制的研究进展[J]. 中国免疫学杂志, 2021, 37（4）: 511-514. LI Y H, LIU J L, WANG T T, et al. Research progress of Ganoderma lucidum polysaccharides in anti-tumor immunomodulatory mechanism[J]. Chinese Journal of Immunology, 2021, 37（4）: 511-514.
[29] 李志强, 何玉霞. 灵芝多糖对人肺癌A549细胞增殖凋亡的作用[J]. 现代食品科技, 2021, 37（5）: 38-42. LI Z Q, HE Y X. The effect of Ganoderma lucidum polysaccharides on proliferation and apoptosis of human lung cancer A549 cells[J]. Modern Food Science & Technology, 2021, 37（5）: 38-42.
[30] 马传贵, 张志秀, 佟富军. 灵芝对心脑血管保护作用的机制及其研究进展[J]. 医学食疗与健康, 2021, 19（5）: 191-192, 205. MA C G, ZHANG Z X, TONG F J. Mechanism and research progress of Ganoderma lucidum on Cardiovascular protection[J]. Medical Diet and Health, 2021, 19（5）: 191-192, 205.
[31] 江和栋, 牛仙, 万仁口, 等. 灵芝孢子多糖的提取工艺优化及单糖组成、抗氧化活性分析[J]. 中国食品学报, 2021, 21（4）: 159-167. JIANG H D, NIU X, WAN R K, et al. Optimization of extraction process and analysis of monosaccharide composition and antioxidant activity of Ganoderma lucidum spore polysaccharides[J]. Journal of Chinese Institute of Food Science and Technology, 2021, 21（4）: 159-167.
[32] 彭灿, 张静, 祝宇龙, 等. 灵芝在中药美容产品中的应用研究进展[J]. 中国美容医学, 2021, 30（3）: 178-182. PENG C, ZHANG J, ZHU Y L, et al. Progress in the applicatin and study on Ganoderma lucidum in Chinese herbal cosmeceutical products[J]. Chinese Journal of Aesthetic Medicine, 2021, 30（3）: 178-182.
[33] 张泽泉, 罗翠婷, 洪臣熙, 等. 延平区野生灵芝中29种元素含量分析[J]. 海峡预防医学杂志, 2020, 26（5）: 49, 110. ZHANG Z Q, LUO C T, HONG C X, et al. Analysis of 29 elements in wild Ganoderma lucidum in Yanping district[J]. Strait Journal of Preventive Medicine, 2020, 26（5）: 49, 110.
[34] 张忠, 张劲松, 唐庆九, 等. 灵芝β-葡聚糖磷酸化衍生物体外抑制肿瘤细胞增值的作用[J]. 食用菌学报, 2020, 27（1）: 63-68 ZHANG Z, ZHANG J S, TANG Q J, et al. The inhibitory effect of Ganoderma lucidum β-glucan phosphorylated derivatives on tumor cell proliferation in vitro[J]. Acta Edulis Fungi, 2020, 27（1）: 63-68.
[35] SONG M, LI Z H,GU H S, et al. Ganoderma lucidum spore polysaccharide inhibits the growth of hepatocellular carcinoma cells by altering Macrophage polarity and induction of apoptosis[J]. J Immunol Res, 2021, 2 021: 6696606.
[36] 陈菲菲, 李畅, 罗毅, 等. 微粒型灵芝孢子β-葡聚糖重塑免疫抑制微环境增强吉西他滨抗肺癌作用[J]. 药学学报, 2021, 56（7）: 1 988-1 998. CHEN F F, LI C, LUO Y, et al. Effect and mechanism of particulate Ganoderma lucidum spore β-glucan in remodeling tumor immunosuppresive Microenvironment as an adjuvant to gemcitabine chemotherapy[J]. Acta Pharmaceutica Sinica, 2021, 56（7）: 1 988-1 998.
[37] 邹佳妤, 石广亮, 姜晓文, 等. 赤灵芝多糖对机体抗氧化作用及免疫功能的影响研究[J]. 中兽医医药杂志, 2016, 35（2）: 52-56. ZOU J Y, SHI G L, JIANG X W, et al. Study on the effects of Ganoderma lucidum polysaccharides on antioxidant activity and immune function in the body[J]. Journal of Traditional Chinese Veterinary Medicine, 2016, 35（2）: 52-56.
[38] 张俊丽, 岳彩娟, 高旭红, 等. 日粮中添加金银花枝条粉对西门塔尔杂代肉牛生长性能及血清生化指标的影响[J]. 饲料研究, 2022, 45（9）: 5-10. ZHANG J L, YUE C J, GAO X H, et al. The effect of adding honeysuckle branch powder to the diet on the growth performance and serum biochemical indicators of simmental hybrid beef cattle[J]. Feed Research, 2022, 45（9）: 5-10.
[39] 徐雪峰, 李桂娟, 闫浩, 等. 赤灵芝多糖分离纯化及体外抗氧化性研究[J]. 食品与机械, 2017, 33（1）: 144-148. XU X F, LI G J, YAN H, et al. Purification and in vitro antioxidant activity of polysaccharides from Ganoderma lucidum[J]. Food & Machinery, 2017, 33（1）: 144-148.
[40] 田文妮, 肖南, 张全才, 等. 连续动态逆流提取对赤灵芝多糖抗氧化活性的影响[J]. 食品科技, 2019, 44（7）: 245-249. TIAN W N, XIAO N, ZHANG Q C, et al. Effect of continuous dynamic countercurrent extraction on antioxidant activity of Ganoderma lucidum Karst polysaccharide[J]. Food Science and Technology, 2019, 44（7）: 245-249.
[41] 何嘉烽, 吴小勇, 尹辉, 等. 水溶性灵芝粉的制备及其免疫调节活性评价[J]. 广东药科大学学报, 2018, 34（3）: 288-292. HE J F, WU X Y, YIN H, et al. Preparation of water-soluble Ganoderma lucidum powder and evaluation of its immunomodulatory activity[J]. Journal of Guangdong Pharmaceutical University, 2018, 34（3）: 288-292.
[42] 苏保洲. 灵芝的现代临床应用探索[J]. 现代中西医结合杂志, 2019, 28（5）: 567-570. SU B Z. Exploration of modern clinical application of Ganoderma lucidum[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2019, 28（5）: 567-570.
[43] 杨秋霞, 杨运云, 刘耀慧, 等. 傅立叶变换离子回旋共振质谱法对赤灵芝的化学成分鉴定和指纹图谱研究[J]. 分析测试学报, 2019, 38（5）: 525-531. YANG Q X, YANG Y Y, LIU Y H, et al. Identification of chemical constituents and fingerprint of Ganoderma lucidum by fourier transform ion cyclotron resonance mass spectrometry[J]. Journal of Instrumental Analysis, 2019, 38（5）: 525-531.
[44] 颜梦秋, 刘艳芳, 唐传红, 等. 食药用菌液发酵产品在食品领域应用进展[J]. 食品与机械, 2023, 39（8）: 227-233, 240. YAN M Q, LIU Y F, TANG C H, et al. Application progress of liquid fermentation products of edible and medicinal fungi in food industry[J]. Food & Machinery, 2023, 39（8）: 227-233, 240.
[45] PAN K, JIANG Q G, LIU G Q, et al. Optimization extraction of Ganoderma lucidum polysaccharides and its immunity and antioxidant activities[J]. International Journal of Biological Macromolecules, 2013, 55: 301-306.
[46] SUN L X, LIN Z B, DUAN X S, et al. Stronger cytotoxicity in CTLs with granzyme B and porforin was induced by Ganoderma lucidum polysaccharides acting on B16F10 cells[J]. Biomedicine & Preventivenutrition, 2012, 2: 113-118.
[47] 陈春玲, 姜思羽, 吴迪生, 等. 赤灵芝对小鼠镇静催眠作用的研究及机制分析[J]. 时珍国医国药, 2019, 30（4）: 769-770. CHEN C L, JIAGN S Y, WU D S, et al. Study and mechanism analysis of the sedative and hypnotic effects of Ganoderma lucidum on mice[J]. Lishizhen Medicine and Materia Medica Research, 2019, 30（4）: 769-770.
[48] 高应娟, 罗舒, 宋怡, 等. 灵芝抗炎机制研究进展[J]. 中国食用菌, 2021, 40（9）: 1-4, 10. GAO Y J, LUO S, SONG Y, et al. Research progress on anti-inflammatory mechanisms of Ganoderma lucidum[J]. Edible Fungi of China, 2021, 40（9）: 1-4, 10.
[49] 林伟龙, 李兆安, 蔡金艳. 复方赤灵芝营养粉对小鼠抗疲劳作用和氧化损伤模型小鼠的影响[J]. 广东药科大学学报, 2019, 35（2）: 242-245. LIN W L, LI Z A, CAI J Y. Effect of compound red Ganoderma nutrition powder on anti fatigue and oxidative damage model mice[J]. Journal of Guangdong Pharmaceutical University, 2019, 35（2）: 242-245.
[50] 张维珂, 张丛丛. 泰山赤灵芝延缓运动员运动性疲劳的实验研究[J]. 体育科技, 2014, 35（6）: 77-78, 87. ZHANG W K, ZHANG C C. Experimental study on the effect of Taishan Ganoderma on delaying sports fatigue[J]. Sport Science and Technology, 2014, 35（6）: 77-78, 87.
[51] 李晨, 吕晨曦, 吴磊. 泰山赤灵芝对重复运动后骨骼肌微损伤的保护作用研究[J]. 泰山医学院学报, 2014, 35（8）: 711-716. LI C, LU C X, WU L. Study on the protective effect of Taishan Ganoderma on skeletal muscle microinjury after repeated exercise[J]. Journal of Taishan Medical College, 2014, 35（8）: 711-716.
[52] 李盼, 曾祥权, 李倩倩, 等. 块菌多糖的提取、结构、功能及应用研究进展[J]. 食品与机械, 2024, 40（2）: 213-220. LI P, ZENG X Q, LI Q Q, et al. Research progress on extraction, structural, functional properties and application of Tuber polysaccharides[J]. Food & Machinery, 2024, 40（2）: 213-220.
[53] 张文婧, 刘欢, 李红波, 等. 富硒平菇菌种筛选、发酵优化及菌丝特性评价[J/OL]. 食品与生物技术学报. （2024-03-07） [2024-04-11]. http://kns.cnki.net/kcms/detail/32.1751.TS.20240304.1100.002.html. ZHANG W J, LIU H, LI H B, et al. Screening,fermentation optimization, and mycelia characterization of selenium-enriched Pleurotus ostreatrs strains[J/OL]. Journal of Food Science and Biotechnology. （2024-03-07） [2024-04-11]. http://kns.cnki.net/kcms/detail/32.1751.TS.20240304.1100.002.html.
[54] ZHAO C, ZHANG C C, ZHENG X, et al. Pharmacological effects of natural Ganoderma and its extracts on neurological diseases: a comprehensive review[J]. International Journal of Biological Macromolecules, 2019, 121: 1 160-1 178.