Effects of a canned infant juice auxiliary food on acute inflammation in young mice and antioxidant activity

Authors

DAI Zhiyong, Homologous Innovation Laboratory of Medicine and Food , Hunan University of Traditional Chinese Medicine , Changsha , Hunan 410208 , China ;Engnice Holding Group Co ., Ltd., Changsha , Hunan 410000 , China
DENG Bin, Homologous Innovation Laboratory of Medicine and Food , Hunan University of Traditional Chinese Medicine , Changsha , Hunan 410208 , China ;School of Pharmacy , Hunan University of Chinese Medicine , Changsha , Hunan 410208 , China
LI Jiani, Homologous Innovation Laboratory of Medicine and Food , Hunan University of Traditional Chinese Medicine , Changsha , Hunan 410208 , China ;School of Pharmacy , Hunan University of Chinese Medicine , Changsha , Hunan 410208 , China
XIAO Zuowei, Homologous Innovation Laboratory of Medicine and Food , Hunan University of Traditional Chinese Medicine , Changsha , Hunan 410208 , China ;School of Pharmacy , Hunan University of Chinese Medicine , Changsha , Hunan 410208 , ChinaFollow
ZHOU Yimiao, Homologous Innovation Laboratory of Medicine and Food , Hunan University of Traditional Chinese Medicine , Changsha , Hunan 410208 , China ;School of Pharmacy , Hunan University of Chinese Medicine , Changsha , Hunan 410208 , China ;Xiangyin Campus of Xiangxing College of Hunan University of Traditional Chinese Medicine , Yueyang , Hunan 414615 , China

Corresponding Author(s)

肖作为（1981—），男，湖南中医药大学药学院副教授，博士。E-mail：574512660@qq.com

Abstract

［Objective ］ To investigate the effects of an infant juice canned auxiliary food on acute inflammation and antioxidant activity in young mice.[Methods ] 70 mice were divided into blank group,model group,low dose group (8.697 9 g/kg ),middle dose group (17.395 8 g/kg ),high dose group (34.791 6 g/kg ),high dose group (69.583 2 g/kg ) and positive drug control group.Adopting croton oil -induced acute ear edema model in mice to evaluate the effects of juice canned supplementary food on acute inflammation in young mice;calculated the swelling rate of left ear in each group of mice except the blank group.The levels of TNF -α,IL-2,IL-6 and IL -1β in serum were detected by ELISA.HE staining was used to detect the pathological morphology of liver tissue in mice.Electronic tongue for taste analysis.The antioxidant capacity (DPPH free radical scavenging ability,·OH free radical scavenging ability of infant canned auxiliary food was determined by ultraviolet spectrophotometry.[Results ] Compared with the blank group,the left ear swelling of the model group was 周一苗 （1981 —），女，湖南中医药大学讲师，硕士。E-mail：15988874 @qq.comobvious,the contents of TNF -α,IL-6 and IL -1β in serum were significantly increased (P<0.05),the content of IL -2 was significantly decreased (P<0.05),and the infiltration of inflammatory cells in liver tissue was obvious.Compared with the model group,the swelling degree of the left ear of the mice in the low,medium,high and ultra -high dose groups gradually decreased with the increase of the dose (P<0.05),and the contents of TNF -α,IL-6 and IL -1β in the serum decreased.The difference was statistically significant (P<0.05),and the degree of decrease increased with the increase of the dose.The content of IL -2 in the high -dose and ultra -high -dose groups of mice increased (P<0.05),and the inflammatory symptoms were alleviated.The results of HE staining showed that the degree of nuclear swelling in liver tissue of mice in the medium,high and ultra -high dose groups was significantly improved,and the diffuse inflammatory cell infiltration was reduced.The antioxidant results showed that the IC50 of DPPH free radical scavenging rate and OH free radical scavenging rate were 0.023 mg/mL and 0.022 mg/mL (based on total phenols in the sample ),respectively.[Conclusion ] This kind of infant juice canned auxiliary food has a good anti -inflammatory effect on the acute inflammation of young mice caused by croton oil.

Publication Date

2-18-2025

First Page

131

Last Page

137

DOI

10.13652/j.spjx.1003.5788.2023.80784

Recommended Citation

Zhiyong, DAI; Bin, DENG; Jiani, LI; Zuowei, XIAO; and Yimiao, ZHOU (2025) "Effects of a canned infant juice auxiliary food on acute inflammation in young mice and antioxidant activity," Food and Machinery: Vol. 40: Iss. 9, Article 19.
DOI: 10.13652/j.spjx.1003.5788.2023.80784
Available at: https://www.ifoodmm.cn/journal/vol40/iss9/19

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